| 80 annonces en Modélisation Moléculaire [MM]. | Retour aux annonces |
| Date | Statut | P/P | Titre | Pays | |
|---|---|---|---|---|---|
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11/07/2017 | Postdoc | prive | iZI88cd5jkHd | fxORIcdvJ |
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27/06/2007 | Stage | prive | amour | france |
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31/08/2005 | Postdoc | public | Post-docs in computational structural biology | USA |
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07/11/2003 | CDI | public | Bioinformatics Research Scientist | Etats-Unis |
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06/11/2003 | CDI | public | Computational Chemist | Etats-Unis |
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06/11/2003 | Postdoc | public | Post doctoral (tout-niveau) | Inde |
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05/11/2003 | CDI | prive | Molecular Modeler | Etats-Unis |
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21/10/2003 | CDI | prive | Scientific Programmer | Etats-Unis |
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18/09/2003 | CDD | prive | Cadre post-doc | France |
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09/09/2003 | CDI | prive | BIOMEDICAL INFORMATICS - Research Scientist | Etats-Unis |
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03/08/2003 | CDI | prive | Drug Designer @ Bybrigencics | France |
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03/08/2003 | Postdoc | public | Postdoctoral Fellowship | Etats-Unis |
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03/08/2003 | Postdoc | public | Postdoctoral position in Bio-Geometry | France |
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02/08/2003 | Postdoc | public | Post-Doctoral Research Fellowships | Etats-Unis |
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13/06/2003 | Thèse | public | These en modelisation quantique moleculaire a l'Ecole | France |
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13/06/2003 | Thèse | public | These en Biologie structurale cryomicroscopie 3D et modelisation | France |
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11/06/2003 | Postdoc | public | POSTDOCTORAL POSITION in COMP.CHEM./COMP. BIOPHYSICS | Etats-Unis |
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10/06/2003 | Thèse | public | Simulation Numérique des Métalloprotéines Impliquées dans la Toxicologie | France |
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10/06/2003 | Thèse | public | Prédiction par bioinformatique de la spécificité de reconnaissance des domaines FHA régulateurs | France |
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10/06/2003 | Thèse | public | Rôle de la protéine SGT1 dans le cycle cellulaire, une approche | France |
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10/06/2003 | Thèse | public | Etude structure-fonction et modélisation moléculaire des transporteurs ABC de type MRP | France |
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10/06/2003 | Thèse | public | Simulation Numérique du Comportement Intracellulaire | France |
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10/06/2003 | CDI | prive | Computational Chemists/C++ | Etats-Unis |
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10/06/2003 | CDI | prive | development of advanced algorithms for ligand and structure-based drug design and chemical informatics | Etats-Unis |
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10/06/2003 | CDD | public | SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY | Allemagne |
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10/06/2003 | Postdoc | public | Postdoctorals Fellowships in Structural Molecular Biology at the EMBL Outstation | France |
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10/06/2003 | Postdoc | public | POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY | Allemagne |
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21/05/2003 | CDI | prive | computational chemists (multiple positions) | Etats-Unis |
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24/04/2003 | CDI | prive | Computational Chemists | Etats-Unis |
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24/04/2003 | Postdoc | public | Post-Doctorat au CEA Saclay | France |
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17/04/2003 | Postdoc | prive | Cadre de laboratoire - CDD 18 mois - modelisation moléculaire | France |
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08/04/2003 | CDI | prive | Computational Chemists | Etats-Unis |
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07/04/2003 | CDI | public | SOFTWARE ENGINEER / SCIENTIFIC PROGRAMMER IN PROTEIN CRYSTALLOGRAPHY | Allemagne |
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07/04/2003 | CDI | public | SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY | Allemagne |
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07/04/2003 | Postdoc | public | POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY | Allemagne |
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07/04/2003 | Postdoc | public | Post-doctoral Postion in Structural Genomics | Etats-Unis |
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06/04/2003 | Postdoc | public | Postdoctoral position: Biomolecular NMR and Modelling | Suisse |
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06/04/2003 | Postdoc | public | Post-doctorants CDD 18 moisINRA | France |
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06/04/2003 | Postdoc | prive | Postdoc position at Johnson & Johnson - virtual screening (VS) in drug discovery | France |
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06/04/2003 | Maître de Conférence | public | MdC Bioinformatique moléculaire et structurale | France |
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10/02/2003 | Postdoc | public | PhD Position, Computational Molecular Biology | Canada/Quebec |
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06/02/2003 | Postdoc | public | Postdoctoral Position in Protein NMR in Massachusetts | Etats-Unis |
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29/01/2003 | CDI | prive | Mathematicien - Modelisation dynamique en biologie | France |
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29/01/2003 | Postdoc | public | Postdoc in COMPUTATIONAL MEDICINAL CHEMISTRY | Grande-Bretagne |
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09/01/2003 | CDI | public | Poste CR2 Bioinformatique appliquée à l'analyse des séquences des protéines | France |
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02/01/2003 | Postdoc | public | Postdoctoral position in biological NMR spectroscopy | Etats-Unis |
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28/10/2002 | Thèse | public | Database Mining en Olfaction | France |
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11/09/2002 | Postdoc | public | Computational Biology or Bioinformatics | Japon |
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10/09/2002 | Postdoc | public | Post-doctoral Computer Programmers in Structural Bioinformatics | Grande-Bretagne |
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05/09/2002 | Postdoc | public | Post Doc en bioinformatique aux NIH, Bethesda, USA | Maryland, USA |
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03/09/2002 | CDD | prive | Chimie-informatique/lead informatics/CRP-VITRY | France |
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30/08/2002 | Thèse | public | Thèse en Modélisation Moléculaire | Grande-Bretagne |
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07/08/2002 | Thèse | prive | Several PhD level openings | France |
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07/08/2002 | CDI | prive | Modélisateur moléculaire chez L'Oréal | France |
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07/08/2002 | Postdoc | public | Postdoctoral Positions in Computational Biomolecular NMR | Japon |
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07/08/2002 | Postdoc | public | PostDoc position in Bioinformatics | Massachussets |
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07/08/2002 | Postdoc | public | Postdoctoral Fellow | Japon |
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06/08/2002 | Thèse | public | Bourse de thèse fléchée Inter///Bio | France |
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06/08/2002 | Thèse | public | Contribution à l'annotation structurale du génome de Botrytis cinerea | France |
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06/08/2002 | Thèse | public | Biology PhD Student in Bioinformatics Laboratory | Massachussets, USA |
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06/08/2002 | CDI | prive | Senior Research Scientist | France |
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30/07/2002 | CDI | prive | Head of Molecular Modelling | France |
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24/07/2002 | Thèse | public | PhD in Bioinformatics/Computational Biochemistry | Grande-Bretagne |
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24/07/2002 | Postdoc | public | Post-Doctoral Research Fellow in Protein Folding | Grande-Bretagne |
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22/07/2002 | Thèse | public | These en chem-informatique / bio-informatique | France |
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18/07/2002 | Postdoc | public | Enzyme Function And Reaction Mechanisms: Computational Studies | Ohio, USA |
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17/07/2002 | Postdoc | public | Two Postdoctoral Fellowships - Machine Learning and Bioinformatics | Grande Bretagne, USA |
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17/07/2002 | Postdoc | public | Enhancing Molecular Docking Through High-Performance Computing and Advanced Visualization | France |
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14/06/2002 | Postdoc | prive | Postdoctoral Research Fellow | Suisse |
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11/02/2002 | CDI | prive | Professor/Reader/Senior Lecturer/Lecturer in Structural Biology and Bioinformatics | Grande-Bretagne |
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07/02/2002 | Postdoc | public | PhD Project Studentship | Ecosse |
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12/07/2001 | Thèse | public | Bourse Mobilité | France |
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03/07/2001 | ATER | public | ATER Physico-Chimie moléculaire et cellulaire au Muséum National d'Histoire Naturelle | France |
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01/07/2001 | Thèse | public | Caractérisation de signatures complexes pour la découverte de nouveaux membres dans des familles de protéines connues. | France |
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01/07/2001 | CDI | prive | Researcher – Protein structure modelling NAUTILUS BIOTECH | France |
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01/07/2001 | Postdoc | prive | ABG-6416 - Position postdoctorale en Modelisation Moleculaire | France |
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01/07/2000 | Thèse | public | deux bourses de thèses à pourvoir. Contexte scientifique : Bioinformatique et Génome | France |
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01/07/2000 | Thèse | public | Bioinformatique du médicament : criblage virtuel de chimiothèques | Suisse |
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01/07/2000 | Thèse | public | bourse de thèse a été attribuée à Nancy pour une recherche commune à un laboratoire d'informatique (LORIA) et de biologie moléculaire dans le domaine des ARN | France |
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01/07/2000 | CDI | prive | Software Developers à Gentech (Sophia antipolis) | France |
| 11/07/2017 | [MM] | iZI88cd5jkHd |
| Source: | 7nXX3drNk |
| Date de parution: | 11/07/2017 | Date limite de réponse: | ? |
| Lieu: | QAX8nAnCqzDs (fxORIcdvJ) | Statut: | Postdoc | Secteur: | prive |
| Description de l'annonce: |
| Gee whiz, and I thhuogt this would be hard to find out. |
| Contacts: | Gee whiz, and I thhuogt this would be hard to find out. |
| 27/06/2007 | [MM] | amour |
| Source: | officiel |
| Date de parution: | 27/06/2007 | Date limite de réponse: | 15/09/2007 |
| Lieu: | rennes (france) | Statut: | Stage | Secteur: | prive |
| Description de l'annonce: |
| chereche personne pouvons m'apprendre à faire l'amour |
| Contacts: | bystere@yahoo.fr |
| 31/08/2005 | [MM] | Post-docs in computational structural biology |
| Source: |
| Date de parution: | 31/08/2005 | Date limite de réponse: | ? |
| Lieu: | Tucson, Arizona (USA) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Post-docs in computational structural biology Applications are invited for several postdoctoral positions starting January 2006 or later in the Department of Biochemistry & Molecular Biophysics at the University of Arizona in Tucson. The initial appointment will be for one year with reappointment for a second year by mutual agreement. Research interests focus on three main areas: 1- Modeling of large supramolecular assemblies using coarse-grained approaches to understand large conformational changes related to the function of these molecules. 2- Physical understanding of these large conformational changes using detailed atomic molecular dynamics simulations. 3- Development and application of novel methods that integrate experimental data such as cryo-EM, FRET, SAXS for large macromolecular assemblies structure prediction. Ideal candidates would have a strong background in computational or theoretical chemistry, biophysics, biochemistry, structural biology or related disciplines. Experience in molecular modeling and simulation of biological systems, advanced programming skills (C, Fortran, Perl), familiarity with UNIX/Linux operating system, and an interest in developing new methodologies are highly desirable but not necessary. |
| Contacts: | Applicants should submit inquiries or applications (a current CV with a publication list, description of research experience and interests, and names of three references) by email: ftama at scripps dot edu Florence Tama Department of Biochemistry and Molecular Biophysics University of Arizona Tucson, AZ USA http://www.scripps.edu/~ftama |
| 07/11/2003 | [MM] | Bioinformatics Research Scientist |
| Source: | http://bioinformatics.org/forums/forum.php?forum_id=2238 |
| Date de parution: | 07/11/2003 | Date limite de réponse: | ? |
| Lieu: | Washington (Etats-Unis) | Statut: | CDI | Secteur: | public |
| Description de l'annonce: |
| The Protein Information Resource (PIR) is seeking a Bioinformatics Research Scientist at the levels of Post-doctoral Research Associate, Research Instructor, OR Research Assistant Professor. The successful candidate will participate in the development of UniProt, a central resource of protein sequence and function that unifies PIR, Swiss-Prot and TrEMBL databases. PIR is a public resource of protein informatics, providing functionally annotated and value-added protein databases as well as bioinformatics tools to support genomic and proteomic research and knowledge discovery. RESPONSIBILITIES: * Developing a Rule-based system for the annotation of functional features (active sites, functional sites, etc) in UniProt database using protein family and structure information * Curating protein families, multiple sequence alignments, and functional rules involving both literature-based and computational approaches * Assisting the development of a web environment for Rule curation REQUIREMENTS: * Ph.D. degree in biochemistry, molecular biology, biophysics, or related disciplines * General knowledge and experience in computational biology/bioinformatics * In-depth knowledge and experience in protein structure and sequence analysis, and in protein databases * Experience in computer programming in the web/unix environment * Ability to work independently with a good publication record * Detail-oriented with excellent analytical skills * Team player with good communication skills |
| Contacts: | Please submit your cover letter and CV via e-mail to jlc57@georgetown.edu, addressed to: Dr. Cathy H. Wu, Director and Professor Protein Information Resource Biochemistry and Molecular Biology Georgetown University Medical Center Washington, D.C. 20057-1414 |
| 06/11/2003 | [MM] | Computational Chemist |
| Source: | http://bioinformatics.org/forums/forum.php?forum_id=2218 |
| Date de parution: | 06/11/2003 | Date limite de réponse: | ? |
| Lieu: | New York State (Etats-Unis) | Statut: | CDI | Secteur: | public |
| Description de l'annonce: |
| A client of ours is seeking a Sr Computational Chemist. QUALIFICATIONS: The candidate should be willing to provide molecular modeling support for discovery projects by applying state-of-the-art computational techniques, with the goal of identifying and optimizing novel drug leads. 3 or more years industrial experience in de-novo ligand design, pharmacophore analyses, ligand docking, library design and analysis, homology modeling and protein-ligand simulations is REQUIRED. Additional requirements include a Ph.D. in Chemistry, Biochemistry, Biophysics, or a related discipline, and excellent communication skills. |
| Contacts: | HOW TO APPLY: If you are interested in pursuing this opportunity, please forward your CV, salary requirement, relocation considerations and references to resumes@workwondersstaffing.net. It is important to use the position title as the subject of your email to allow your resume to reach the appropriate recruiter as quickly as possible. If you feel you are not qualified or are not interested in the opportunity, do you know anyone who might be a good fit? [Please reference Bioinformatics.Org when responding to this announcement.] |
| 06/11/2003 | [MM] | Post doctoral (tout-niveau) |
| Source: | http://bioinformatics.org/forums/forum.php?forum_id=2224 |
| Date de parution: | 06/11/2003 | Date limite de réponse: | ? |
| Lieu: | CHENNAI (Inde) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| ANNA UNIVERSITY, CHENNAI, INDIA AU-KBC RESEARCH CENTRE ( www.au-kbc.org ) LIFE SCIENCES GROUP Positions open for Research Faculty, Post doctoral fellows, Ph.D. Scholars Research faculty and PDFs: Candidates should be capable of contributing to the establishment of a nationally competitive program with the ability to generate externally funded research support. This is an excellent opportunity to grow with a new centre, which already has established facilities in electrophysiology, optical tweezing, Raman spectrometry and molecular biology. While the group?s current emphasis is on membrane biophysics, applications from those working in any other cutting-edge or interdisciplinary area of biology are also welcome. The group have strong alliances with the Centre for Biotechnology, IITM and Matscience, Chennai. PDF?s recruited in this program will be strongly encouraged to become independent researchers. QUALIFICATIONS: Ph. D. scholars: Eligibility: M.Sc or equivalent in biological, chemical or physical disciplines. NET and GATE qualifications an asset. Candidates can apply for Research Studentship under ongoing programs listed below. 1. Permeation of macromolecules through nanopores (DST) 2. Properties of heteromeric gap junctions (Wellcome) 3. High-sensitivity biosensors through optical techniques (DST) 4. Modeling of coordinated tissue function (Wellcome) 5. Single-molecule protein-DNA interaction (DAE) 6. Single-molecule (Raman) spectroscopic imaging of biomolecules & self-assembled biostructures (KBCRF/UGC) 7. Mutations of BRCA1/2 in breast cancer (DST) 8. Information extraction from biomedical abstracts (KBCRF) 9. Suicide gene therapy in breast cancer (DBT) |
| Contacts: | HOW TO APPLY: Write to: The Academic Coordinator Life Sciences Division AU-KBC Research Center MIT,Chromepet,Chennai 600044 Ph: +91-44-2-223-4885 www.au-kbc.org Or Email: academic@au-kbc.org |
| 05/11/2003 | [MM] | Molecular Modeler |
| Source: | Bioinformatiocs.Org |
| Date de parution: | 05/11/2003 | Date limite de réponse: | ? |
| Lieu: | New York (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| I am assisting to recruit Molecular Modeler for a client's Drug Discovery Applications Group in New York City. Here is more information: This client is a technology leader specializing in computational methods for drug discovery and development. Benefits include medical, dental, 401(k), flexible spending account, 3+ weeks vacation, stock options, and tuition reimbursement. Visa sponsorship and/or relocation are available. The successful candidate will become part of a multidisciplinary drug discovery team working on both in-house efforts to improve and apply drug discovery methodologies and on collaborative projects with pharmaceutical/biotechnology partners. JOB DESCRIPTION: Actively participate in Drug Discovery Applications Group projects Apply drug discovery software and perform analysis of the results Effectively communicate results to other members of the Group Work closely with the Development Team to test and improve Drug Discovery technologies QUALIFICATIONS: Ph.D. in computational chemistry, organic chemistry, or biochemistry Computational experience in at least 1 of the following areas: molecular modeling, structure-based drug design, virtual ligand screening, computationally-driven lead optimization, ligand-based design, or homology modeling Excellent verbal and written communication skills Ability to work independently SKILLS: Programming skills: Perl script writing, in particular Experience with chemical databases |
| Contacts: | HOW TO APPLY: For consideration, please send CV including publications, thesis topic, and advisor to resumes@workwondersstaffing.net This client is an Equal Opportunity Employer. [Please reference Bioinformatiocs.Org when replying to this announcement.] |
| 21/10/2003 | [MM] | Scientific Programmer |
| Source: |
| Date de parution: | 20/10/2003 | Date limite de réponse: | ? |
| Lieu: | New York (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| I am assisting to recruit a Scientific Programmer for a client located in New York City. This client is a technology leader specializing in software solutions for life science research and development. They are seeking computational scientists to create the next generation of computer-aided drug design methods, algorithms, and software. Two Ligand-based drug design positions are available for individuals with a background in 3D pharmacophore development (focusing on algorithm and methodology development, not strict modeling) in the New York City office. RESPONSIBILITIES: Participate in scientific and algorithmic development as well as software design and implementation. Extend and maintain large software packages written by others, as well as develop new applications. REQUIREMENTS: Ph.D. in computational chemistry, biochemistry, or biology. Post-doctoral research and/or relevant experience in the commercial sector. Proven skill and experience in ligand-based drug design with specialization in development of 3D pharmacophore models. Experience in methodology development for conformational analysis, pharmacophore feature definition and 3D pharmacophore model identification is preferred. Experience in pharmacophore modeling, 3D ligand-based drug design, and structure-based design experience is a plus. Strong algorithm development and methodology development skills. Strong programming experience. Good knowledge of C/C++ and object-oriented design is a plus. Experience writing and maintaining large (100,000-line-plus) software packages is preferred. Peer-reviewed publications in computational chemistry, bioinformatics, cheminformatics, or computational medicinal chemistry. BENEFITS: Benefits include medical, dental, 401(k), flexible spending account, 3+ weeks vacation, and tuition reimbursement. |
| Contacts: | HOW TO APPLY: send CV (including publications, thesis topic, academic scores and references) to resumes@workwondersstaffing.net. [Please reference Bioinformatics.Org when responding to this announcement.] |
| 18/09/2003 | [MM] | Cadre post-doc |
| Source: |
| Date de parution: | 18/09/2003 | Date limite de réponse: | ? |
| Lieu: | Toulouse (31) (France) | Statut: | CDD | Secteur: | prive |
| Description de l'annonce: |
| POSTE CDD (Cadre post-doc) - R&D Industrie Pharmaceutique - Diversité / Modélisation moléculaire (CHEmogenomics) (28 juillet 2003) Sanofi-Synthélabo Recherche, 2ème groupe pharmaceutique en France, offre 1 poste CDD (cadre post-Doc) de 18 mois (12 + 6 mois) en Chem-Informatique, au sein de son département de : recherche exploratoire. Ce département se consacre à la découverte de nouveaux médicaments et regroupe des activités de recherche en chimie et en biologie. Poste disponible dés le septembre 2003 Missions : au sein du service chimie-informatique et biologie structurale, en collaboration directe avec les chimistes, et les biologistes dans un projet de « chemogenomics », la personne recrutée s.attachera à établir le lien entre des familles de cibles biologiques et des familles de structures chimiques se liant sur ces cibles. Cette étude se basera sur l'exploitation de notre patrimoine chimique et biologique pour annoter des bases chimiques et concevoir des chimiothèques focalisées dans une optique de criblage biologique et virtuel. Qualifications demandées : doctorat en chimie / biochimie spécialité modélisation moléculaire avec une compétence en informatique. Expérience : Bonne maîtrise des environnements UNIX, MS-Window et des langages de scripting (SH/KSH/CHS, PERL.). Bonne connaissance des outils standard de modélisation moléculaire et/ou diversité moléculaire (TRIPOS) et des outils d.alignement de séquence . Une expérience en analyse de données et/ou statistiques serait un plus. Lieu de Travail : Centre de recherche de Toulouse. |
| Contacts: | Candidatures à retourner à : Dr. Jean-Philippe Rameau Sanofi-Synthélabo Recherche 195, Route d'Espagne 31036 Toulouse Cedex E-mail : jean-philippe.rameau@sanofi-synthelabo.com |
| 09/09/2003 | [MM] | BIOMEDICAL INFORMATICS - Research Scientist |
| Source: | BioJobs |
| Date de parution: | 09/09/2003 | Date limite de réponse: | ? |
| Lieu: | (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Responsibilities: Join GE's research in molecular imaging as a Bioinformatics Scientist, working with world-class experts in imaging physics, molecular biology, and medicinal chemistry, developing the next generation of molecular diagnostics. We need experts in bioinformatics analysis of protein pathways and gene expression to develop tools and techniques for discovering molecular imaging targets and apply these techniques to the study of specific diseases. Projects will involve developing platform technologies for integrating many disparate types of public and proprietary genomic and proteomic data along with analysis methods to elucidate pathways and identify molecular imaging targets. Collaborate with GE’s luminary academic and commercial scientific partners both to develop next generation diagnostic products and to publish research results. Requirements: Candidates need to have either a PhD in bioinformatics or computational biology, or degrees in both biological and computational sciences, with one being at the PhD level. ·Knowledge of molecular disease mechanisms and pathways. ·Knowledge of genomics and analysis of DNA microarray data. ·Mathematical and computer science background. ·Published work in the bioinformatics field. ·Excellent communication skills (verbal, written, presentation). ·Ability to work effectively in teams. Demonstrated experience in one or more of the following areas would also be highly desirable: ·Experience in building computational models of biological phenomena. ·Experience in statistical analysis of biological data. ·Experience with microarray tools and algorithms, knowledgeable about their limitations and research areas. ·Experience building bioinformatics databases and software tools. Desired: ·Experience in pharmaceutical or biotech industry. ·Experience as Principal Investigator on funded research grants. ·Leadership / coordination ability. We offer a competitive salary, outstanding benefits package and the professional advantages of an environment that supports your development and recognizes your achievements. |
| Contacts: | To apply to this position, please click on this link. https://www.research.ge.com/eHire Please enter GECRD/319910/WB2273 in the job reference code field. An Equal Opportunity Employer. |
| 03/08/2003 | [MM] | Drug Designer @ Bybrigencics |
| Source: | bioinfo |
| Date de parution: | 18/07/2003 | Date limite de réponse: | ? |
| Lieu: | Paris (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Responsibilities and Tasks : The drug designer will be member of the Drug Discovery department and be in charge of: * The set up and the optimisation of the virtual drug screening platform, together with the Bioinformatics and IT departments. * The communication between the Bioinformatics and Drug Discovery departments. * The compound library design activity. * Assisting the Head of Drug Discovery in structure-activity relationship analyses and lead optimisations. Required : The successful candidate will have a Ph.D in medicinal chemistry or structural biology, with 5 + years experience in the pharmaceutical or biotech industry (library design and virtual drug screening). * The position requires a highly motivated scientist able to set up autonomously a library design and virtual screening platform. * Knowledge in proteomics is a plus. * Good communication skills and ability to present results internally are required. * The applicant must be fluent in English and French. |
| Contacts: | To apply, please send a cover letter and a resume to Caroline Diard, Hybrigenics SA, 3-5 impasse Reille, 75014 Paris. cdiard@hybrigenics.fr Caroline Diard. - Human Resources Manager HYBRIGENICS S.A. - 3/5 Impasse Reille F-75014 PARIS Tel: (+33) 1.58.10.38.12 - Fax: (+33) 1.58.10.38.49 http://www.hybrigenics.com |
| 03/08/2003 | [MM] | Postdoctoral Fellowship |
| Source: |
| Date de parution: | 04/07/2003 | Date limite de réponse: | ? |
| Lieu: | (Etats-Unis) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Postdoctoral Fellowship under the direction of Dr. Ruth Nussinov, in the Laboratory of Experimental and Computation Biology, to conduct research on protein folding and binding. Will involve computational investigation of structural and functional genomics, and the inter-relationship between protein structure and function and probe the coupling between protein folding and function, and protein binding mechanisms. These studies are currently at the forefront of structural bioinformatics, with direct implications for protein and for drug design. Will work with novel, state-of-the art computational tools toward these goals. Ph.D. degree and strong background in molecular calculations; extensive knowledge in protein structures and in molecular simulations; a strong background in biophysics, computational chemistry or structural biology required. SAIC-Frederick, Inc., a subsidiary of SAIC, is the Operations and Technical Support (OTS) Contractor for the National Cancer Institute at Frederick (NCI-Frederick) a federally funded research and development center. The mission of SAIC-Frederick, Inc. is to provide scientific, technical, management, administrative, and logistical support to National Institutes of Health (NIH) intramural laboratory research and development related to the causes of and cures for cancer and AIDS. Intramural research is that conducted by Government scientists operating within various units of NIH, principally the National Cancer Institute (NCI), and the largest institute of NIH. We also conduct basic and applied research in cancer and AIDS; operate and manage the Advanced Biomedical Computing Center (ABCC), the world’s only supercomputer devoted exclusively to biomedical research; and conduct large drug and natural product screening programs. Excellent salary and benefits accompany our positions, including the opportunity to become an employee-owner in the nation’s largest employee owned research and engineering company. Job Information Position Type: Post-Doctoral Research Fellowships Reference (Job ID number): KMB058452 Start Date: ASAP Duration: Full Time Status: open |
| Contacts: | SAIC-Frederick, Inc. Basic Research Program D. Higdon higdon@ncifcrf.gov http://saic.ncifcrf.gov How To Apply: email CV or apply online at http://saic.ncifcrf.gov; or www.saic.com |
| 03/08/2003 | [MM] | Postdoctoral position in Bio-Geometry |
| Source: |
| Date de parution: | 15/07/2003 | Date limite de réponse: | ? |
| Lieu: | Sophia-Antipolis (France) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Two of the most prominent challenges of the the post-genomic era are to understand the molecular machinery of the cell and to develop new drug design strategies. These key challenges require the determination, understanding and exploitation of the three-dimensional structure of several classes of molecules ---nucleic acids, proteins, drugs---, as well as the elucidation of the interaction mechanisms between these molecules. Most importantly, these challenges involve aspects from biology, chemistry, physics, mathematics and computer science. Building upon a long and recognized experience in Computational Geometry and applications, the Geometrica group (formerly Prisme) (http://www-sop.inria.fr/prisme/index.html.en) is launching a research activity in Bio-Geometry ---the geometric component of the afore-mentioned challenges. Along this line, a one year Post-Doc position starting Fall 2003 (October / November / December) is now opened. Its primary focus will be docking ---protein-protein as well as protein-ligand, with potential applications to folding. For these reasons, we encourage the application of: -Bio-(physicists, chemists) with a background in structural biology and an inclination for geometry. -Computer scientists with a background in algorithms design and analysis or computational geometry, and interests in molecular modeling. |
| Contacts: | Applicants with a Ph.D. are encouraged to submit a vitae as well as sample representative publications, and arrange for two letters of recommendation to be sent directly to Frederic Cazals INRIA Sophia-Antipolis, Prisme, 2004 route des Lucioles, BP 93, F-06902 Sophia-Antipolis, France Email: Frederic.Cazals@sophia.inria.fr Note. INRIA is the French Institute for Computer Science and Automation. The Sophia-Antipolis unit is located on the French Riviera. -- Project GEOMETRICA, INRIA Sophia-Antipolis, 2004 route des Lucioles, -- BP 93, F-06902 Sophia-Antipolis, -- Tel: 33 (0)4 92 38 71 88, Fax: 33 (0)4 92 38 76 43 -- Frederic.Cazals@sophia.inria.fr, http://www.inria.fr/prisme |
| 02/08/2003 | [MM] | Post-Doctoral Research Fellowships |
| Source: |
| Date de parution: | 04/07/2003 | Date limite de réponse: | ? |
| Lieu: | Los Angeles (Etats-Unis) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Keck Graduate Institute of Applied Life Sciences Postdoctoral Fellow The Keck Graduate Institute of Applied Life Sciences is seeking a highly creative and motivated postdoctoral research fellow to participate in the following research area: Development of Bayesian network models and machine learning methods for protein structure prediction. This project is part of a collaborative effort to develop a community resource to enable the emerging science of structural genomics. Candidates should have a Ph.D. in computational biology, computer science, machine learning, theoretical physics, applied mathematics, or a similar quantitative field and a strong interest in molecular biology. KGI is located 35 miles east of Los Angeles, at the foot of the San Gabriel Mountains. Its campus is contiguous with those of the other Claremont Colleges, which together with surrounding educational institutions in Southern California provide a rich intellectual and cultural environment. The position forms part of a collaborative research project between KGI, UCL, UCSD and the Burnham Institute. The successful candidate will be based at KGI and work in close collaboration with the Gatsby Unit for Computational Neuroscience at University College London. |
| Contacts: | Prospective candidates should apply with a cover letter and CV, and ask for at least two letters of recommendation to be sent to Dr. David Wild at: Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711. Email: david_wild@kgi.edu. Contact Information Keck Graduate Institute David Wild david_wild@kgi.edu Tel. Number: 909-607-8566 FAX Number: 909-607-8086 www.kgi.edu |
| 13/06/2003 | [MM] | These en modelisation quantique moleculaire a l'Ecole |
| Source: | ABGt-2938 |
| Date de parution: | 10/06/2003 | Date limite de réponse: | 06/07/2003 |
| Lieu: | Paris (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Date de debut de diffusion du poste : 10/06/2003 Date de fin de diffusion prevue : 06/07/2003 Modelisation microscopique et optimisation des proprietes de molecules d’interet pharmaceutique : complementarite avec des etudes experimentales Plusieurs molecules d’interet pharmaceutique, ayant une action anti-tumorale reconnue, ont fait l’objet d’etudes structurales poussees. Par exemple le busulfan a ete etudie au laboratoire SPMS, sous la responsabilite de N. Ghermani. Cette molecule, et d’autres, ont pu etre cristallisees, et etudiees par diffraction X haute resolution : ceci a permis une analyse detaillee de la densite electronique(1). La comprehension du comportement alkylant d’une telle molecule au niveau de l’ADN ou des cellules necessite une analyse theorique poussee. Cette molecule est par ailleurs tres active, et des etudes sont en cours pour en empecher la cristallisation en milieu biologique, cause reconnue de deces. Il s’agit essentiellement d’encapsuler des molecules, tout en maintenant la reconnaissance des sites d’action bio-chimique. En dehors du travail primordial de pharmaco-technie, il apparait important de comprendre par voie theorique puis de controler par modelisation les mecanismes microscopiques qui sont en jeu. Cet objectif est commun a de nombreuses molecules vectorisees par des nano-particules pharmacologiques. Les grandes phases du travail de these seraient les suivantes : 1. Etude theorique de la molecule de busulfan (et aussi d’autres molecules presentant la meme problematique de forte cristallisation) et comparaison avec les resultats experimentaux . Modelisation de l’interaction molecule-ADN. 2. Modelisation des forces de cohesion qui favorisent la cristallisation. Cette phase fera largement appel a la description d’un solide en termes de « clusters ». 3. Description des interactions dans une molecule en capsulee dans un vecteur ou une nano-particule. Dans cette phase, a la fois l’approche par cluster et la modelisation conformationnelle developpees ces dernieres annees seront importantes. Ce travail trouvera un prolongement sur des objectifs plus larges : 4. Modelisation des interactions entre nanoparticules. 5 . Modelisation de l’interaction complexe-site actif. Un tel projet s’inscrit directement dans la ligne des travaux developpes au niveau theorique dans l’UMR ces dernieres annees, ainsi que dans l’operation scientifique « materiaux d’interet pharmaceutique », mixte UFR de Pharmacie / ECP. Il permettrait un pont avec une operation scientifique prioritaire actuelle. Il est certain que l’etude ne peut avancer que par une interaction permanente entre des composantes pharmacotechnique, structurale et theorique. Le directeur de these serait Jean Michel Gillet, soutenu en co-direction par Nour Eddine Ghermani d’une part (pour les aspects biochimique et structural) et Pierre Becker d’autre part (concernant la reflexion sur les modeles a mettre en œuvre) A noter enfin qu’une telle collaboration, si elle est un succes, peut deboucher sur des applications a terme mettant en jeu des grands groupes pharmaceutiques. Jean Michel GILLET, ECP et SPMS Nour Eddine GHERMANI, Paris XI et SPMS Pierre BECKER, ECP et SPMS References : 1. Experimental electron density and electrostatique potential analysis of Zinc (aspirinate)2(H2O)2 complex : a 3d10 metal bonding to a drug ligand A. Spasojevic-de Bire, N. Bouhmaida, A. Kremenovic, G. Morgant, N.E. Ghermani (2002), J. Phys. Chem. A, 106, 12170-12177 2. A new approach to the electron distribution in flexible molecules. Application to conformational analysis P. Becker, E. Bec, (1996) Chem. Phys. Letters, 260, 319 3. Interpreting Compton anisotropy of ice Ih : a cluster partitioning method S. Ragot, J.M. Gillet, P. Becker, Phys Rev. B, 63, (2002) 235115-1 to 235115-6 4. Electrostatic properties of ibuprofen N.E. Ghermani, M. Dutheil, P. Becker, J. Chem. Phys. (2002), 117, 205-212 Une bonne formation en physique ou chimie quantique est essentielle. Une precedente experience dans la modelisation moleculaire serait appreciable. Un bon classement de DEA sera un atout favorable, sinon determinant,dans l'obtention d'une bourse de l'Ecole Doctorale de l'Ecole Centrale Paris. Tous les cours de l'ECP sont accessibles aux doctorants du laboratoire SPMS, avec la possibilite de valider le Diplome d'Etudes Superieures Professionnelles delivre par l'Ecole Centrale Paris. Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre. |
| Contacts: | Envoyer un CV ainsi qu'une lettre de motivation (sous la forme d'un courrier electronique avec CV en document attache) a gillet@spms.ecp.fr |
| 13/06/2003 | [MM] | These en Biologie structurale cryomicroscopie 3D et modelisation |
| Source: | BGt-2935 |
| Date de parution: | 06/06/2003 | Date limite de réponse: | 01/07/2003 |
| Lieu: | Paris (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| sur bourse flechee du Ministere. Date de debut de diffusion du poste : 06/06/2003 Date de fin de diffusion prevue : 01/07/2003 Titre de la these : "Etude structurale du complexe MARS (Multi-Aminoacyl-tRNA Synthetase) par cryomicroscopie electronique tridimensionnelle et modelisation moleculaire." Presentation du Sujet Contenu scientifique du programme de la these: Les aminoacyl-tRNA synthetases (ARS) de procaryotes existent a l'etat isole, et leur structure moleculaire a ete intensivement etudiee par cristallographie X. Chez les eucaryotes superieurs, certaines ARS sont regroupees sous forme de complexes multi-enzymatiques dont la structure et la fonction sont encore mal comprises. On rencontre chez les mammiferes un complexe forme de neuf ARS (Asp- Lys- Arg- Gln- Met- Leu- Ile- et GluPro-RS dont les masses moleculaires varient de 56 a 163kDa), et de trois peptide s de soutien denommes p43, p38, et p18. L'architecture et la structure moleculaire de ce complexe de 1 mega-daltons fait l'objet de la these. Pour le stage de la formation doctorale, l'etude structurale du complexe multi-ARS sera poursuivie en suivant deux axes : - 1 - Localisation des composants du complexe en utilisant des marqueurs specifiques La reconstitution 3D et la localisation des composants intrinseques de ce complexe seront realises sur du complexe isole dans le laboratoire du Dr Marc Mirande (LEBS, Gif-sur-Yvette) en utilisant des marquages specifiques avec les fragments Fab d'anticorps mono-clonaux. Une approche similaire mais utilisant des tRNA purifies et marques a l'or (Nanoprobe Inc.) est egalement envisagee en collaboration avec le Pr Mona T. Norcum (University of Mississippi). D'autre part, le Dr. Mirande procedera a une exploration de la biosynthese des proteines chez l'homme par approche proteomique du type " Tag-Tag " qui utilise un double crible de selection. Les proteines seront exprimees par des plasmides permettant l'insertion des peptides appats [Proteine A] et [peptide liant la calmoduline]. (Cibles: 9 ARS + P18, P38, P43 + sous-unites du complexe EF1B +ValRS ; Systeme d'expression: cellules humaines HeLa). Les complexes solubles purifies seront observes et reconstruits par l'etudiant en utilisant les techniques de cryomicroscopie electronique et analyse d'images. La comparaison des volumes de reconstruction 3D obtenus avec les images du complexe Multi-ARS marque et nu permettra de localiser chaque type d'enzyme et de mettre en evidence les composantes du complexe impliques dans des interactions avec des proteines extrinseques au complexe. - 2 - Modelisation moleculaire des ARS de mammifere et recalage des donnees de cryoMET 3D La structure des enzymes procaryotes homologues a celles impliquees dans le complexe MARS sont disponibles dans la PDB. A l'aide de la technique dite "Hydrophobic Cluster Analysis" developpee au LMCP par Jean-Paul Mornon et Isabelle Callebaut [4], l'etudiant realisera des modeles moleculaires de chaque constituants et les positionnera entre eux pour former un modele du complexe global. References: 1.Quevillon S, et al.(1999) J. Mol. Biol. 285: 183-195. 2.Norcum MT, Warrington JA. (2000) J. Biol. Chem. 275:17921-4. 3.Norcum M, Boisset N. (2002) FEBS Letters 512: 298-302. 4.Callebaut, I., et al. (1997) Cell Mol Life Sci 53: 621-45. |
| Contacts: | Pour tout renseignement contactez Nom et prenom du Directeur de these : Dr BOISSET Nicolas Telephone : 01 44 27 45 85 Telecopie : 01 44 27 37 85 E.mail : Nicolas.Boisset@lmcp.jussieu.fr URL: http://www.lmcp.jussieu.fr/~nboisset/microscopy.html Documents a fournir : (Curriculum vitae + Lettre de motivation) Adresse : Dr Nicolas BOISSET, Charge de Recherche CNRS Laboratoire de Mineralogie Cristallographie Paris Universite Paris 6, UMR 7590 IPGP, P7, CNRS Case 115, Tour 16, 2eme Etage, Couloir 15/25 4 place Jussieu 75252 Paris Cedex 05, France. Merci de faire reference a l'ABG et au numero de cette offre lorsque vous ferez acte de candidature |
| 11/06/2003 | [MM] | POSTDOCTORAL POSITION in COMP.CHEM./COMP. BIOPHYSICS |
| Source: | BioInfo |
| Date de parution: | 11/06/2003 | Date limite de réponse: | ? |
| Lieu: | La Jolla (Etats-Unis) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Applications are invited for a postdoctoral position starting September 2003 or later in the Department of Biochemistry & Molecular Biology within the Center for Biological Modeling at Michigan State University (http://biomodel.msu.edu/). The position is available initially for 1 year with the possibility for extension. Research interests focus on three main areas: Modeling of large supramolecular assemblies, in particular interactions between mismatched DNA and the mismatch recognition protein mutS; development of hybrid explicit/implicit solvation methods; and development and application of novel methods for protein structure prediction and refinement. Ideal candidates would have a strong background in computational or theoretical chemistry, biophysics, biochemistry, structural biology or related discplines. Familiarity with computational chemistry methods, experience in molecular modeling and simulation of biological systems, advanced programming skills, knowledge of the UNIX/Linux operating system, and an interest in developing new methodologies are highly desirable. MSU, located in East Lansing, Michigan, provides a unique and challenging interdiscplinary research environment at the interface of biological and physical sciences. East Lansing, located between the Great Lakes, offers a pleasant living environment with many cultural events and excellent opportunities for outdoor activities. |
| Contacts: | Interested applicants should send a curriculum vitae, including relevant experiences, a list of publications, and contact information of three references, to the address listed below. Electronic responses are highly encouraged. Michael Feig Department of Molecular Biology, TPC-6 The Scripps Research Institute 10550 N Torrey Pines Road La Jolla, CA 92037 USA email: meikel@scripps.edu http://www.scripps.edu/~meikel/msu/feig.html Comments? Post your replies to http://bioinformatics.org/forums/forum.php?forum_id=1856 |
| 10/06/2003 | [MM] | Simulation Numérique des Métalloprotéines Impliquées dans la Toxicologie |
| Source: | http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-105.html |
| Date de parution: | 10/06/2003 | Date limite de réponse: | ? |
| Lieu: | Grenoble (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
Proposition de sujet de thèse SL-DSV-03-105 DSV Domaine de recherche Sciences du vivant/Bio-informatique, simulation bio-moléculaire 1. Intitulé du sujet Simulation Numérique des Métalloprotéines Impliquées dans la Toxicologie Topic tittle Numerical Simulation of Metalloproteins Implicated in Toxicology 2. Détail du sujet Les métalloprotéines ont une importance primordiale dans tous les domaines de la biologie. Pourtant, vu la complexité de leur structure et de leur fonctionnement, ils ont besoin d'outils théoriques spécialement adaptés. Le projet proposé pour cette thèse concerne la modélisation de métalloprotéines et, principalement, celles qui sont importantes pour la toxicologie. Ce travail consistera en l'étude de la fixation des métaux et de la dynamique des protéines. Detailed tittle Metalloproteins are of crucial importance in all areas of biology. However, given the complexity of their structure and function, special simulation techniques are needed to treat them. The project proposed for this thesis concerns the modeling of metalloproteins and, in particular, those that are important in toxicology. The work will study how the metals bind to the proteins and how they influence their dynamics. 3. DEA recommandés DEAs de Modélisation, de Physique, de Chimie, de Biologie Structurale ou de Biologie Moléculaire. 4. Informations pratiques Direction des sciences du vivant/Institut de Biologie Structurale Date souhaitée pour le début de la thèse : 1/10/2003 |
| Contacts: | Personnes à contacter par le candidat Martin Field LDM/Laboratoire de Dynamique Moléculaire IBS 41 rue J. Horowitz 38027 Grenoble Téléphone : +33 4-38-78-95-94 |
| 10/06/2003 | [MM] | Prédiction par bioinformatique de la spécificité de reconnaissance des domaines FHA régulateurs |
| Source: | http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-040.html |
| Date de parution: | 10/06/2003 | Date limite de réponse: | ? |
| Lieu: | Gif sur Yvette (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Domaine de recherche Sciences du vivant/Bio-informatique, simulation bio-moléculaire, Sciences du vivant/Biologie structurale 1. Intitulé du sujet Prédiction par bioinformatique de la spécificité de reconnaissance des domaines régulateurs : le cas des domaines FHA Topic tittle Predicting the binding specificity of regulatory domains using bioinformatics : the case of the FHA domains. 2. Détail du sujet Les domaines FHA sont particulièrement présents dans les protéines impliquées dans la réponse au stress génotoxique. L'objectif du travail consistera à coupler modélisation moléculaire et analyse des génomes pour prédire pour chaque domaine FHA sa spécificité de reconnaissance et proposer ainsi des partenaires potentiels pour les protéines contenant ces domaines. Detailed tittle FHA domains are found in many proteins involved in the stress response to DNA damage. Based on systematic modelling and genome analysis we want to predict the binding specificities of these domains and propose potential partners for the proteins harbouring these domains. 3. DEA recommandés Analyse de génomes et Modélisation Moléculaire. Biophysique Moléculaire. 4. Informations pratiques Direction des sciences du vivant/Département de Biologie Joliot Curie Service : Service de Biophysique des Fonctions Membranaires Date souhaitée pour le début de la thèse : 1/09/2003 |
| Contacts: | 5. Personnes à contacter par le candidat Raphaël Guerois LBPM/Laboratoire de Biophysique des Protéines et des Membranes CEA Saclay. 91191 Gif sur Yvette Cedex Téléphone : +33 1 69 08 96 79 |
| 10/06/2003 | [MM] | Rôle de la protéine SGT1 dans le cycle cellulaire, une approche |
| Source: | http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-041.html |
| Date de parution: | 10/06/2003 | Date limite de réponse: | ? |
| Lieu: | Gif sur Yvette (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Proposition de sujet de thèse SL-DSV-03-041 DSV Domaine de recherche Sciences du vivant/Bio-informatique, simulation bio-moléculaire, Sciences du vivant/Biologie structurale 1. Intitulé du sujet Rôle de la protéine SGT1 dans le cycle cellulaire, une approche bio-informatique et structurale Topic tittle SGT1 function in cell cycle regulation probed by biocomputing and structural biology. 2. Détail du sujet SGT1 est une protéine très conservée, essentielle à la régulation du cycle cellulaire. Sa fonction exacte demeure inconnue. Prédiction de structure, docking et RMN seront associés pour caractériser comment SGT1 interagit avec ses multiples partenaires biologiques. En étroite collaboration avec des généticiens et des biologistes des plantes, ce travail permettra d'établir le role de la protéine au cours du cycle cellulaire. Detailed tittle SGT1 is an essential component of the cell cycle signalling pathway although its function remains unclear. Structure prediction, docking and NMR will be used to unravel the way SGT1 interacts with its numerous biological partners. In close collaboration with geneticists and plant biologists, this work will shed light on the role of SGT1 in the cell cycle. 3. DEA recommandés DEA Analyse de génomes et Modélisation Moléculaire. DEA Biophysique Moléculaire. 4. Informations pratiques Direction des sciences du vivant/Département de Biologie Joliot Curie Service : Service de Biophysique des Fonctions Membranaires Date souhaitée pour le début de la thèse : 1/09/2003 |
| Contacts: | 5. Personnes à contacter par le candidat Raphaël Guerois LBPM/Laboratoire de Biophysique des Protéines et des Membranes CEA Saclay. 91191 Gif sur Yvette Cedex Téléphone : +33 1 69 08 96 79 |
| 10/06/2003 | [MM] | Etude structure-fonction et modélisation moléculaire des transporteurs ABC de type MRP |
| Source: | http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-117.html |
| Date de parution: | 10/06/2003 | Date limite de réponse: | ? |
| Lieu: | Grenoble (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Proposition de sujet de thèse SL-DSV-03-117 DSV Domaine de recherche Sciences du vivant/Bio-informatique, simulation bio-moléculaire 1. Intitulé du sujet Etude structure-fonction et modélisation moléculaire des transporteurs ABC de type MRP Topic tittle Structure-function and molecular modelling of MRP-type ABC transporters 2. Détail du sujet Sur la base des données structurales parcellaires obtenues récemment par microscopie et cristallographie, il s'agira d'élaborer des modèles des transporteurs ABC homologues SUR, YCF1, MRP1 en utilisant les contraintes imposées par nos résultats. Ces modèles permettront d'une part de mieux interpréter les résultats connus et d'autre part de formuler des hypothèses sur les mécanismes et de concevoir des expériences pour les tester. Ce projet demandera des compétences en bioinformatique ainsi qu'en biologie et sera réalisé en parallèle dans l'équipe de simulation et modélisation moléculaire et de l'équipe Transporteurs ABC du laboratoire. Detailed tittle On the basis of existing structural data obtained by microscopy and crystallography, models of the homologous ABC transporters, SUR, YCF1 and MRP1 will be constructed using constraints imposed by our experimental results. These models will allow a better interpretation of known data and will constitute a basis for bringing forth hypothesis on the mechanisms and for designing experiments to test these hypothesis. This project will require knowledge of bioinformatics as well as biology and will be pursued in parallel in the Molecular Simulation and Modelisation group and the ABC transporters group of the laboratory. 3. DEA recommandés Modélisation, Mathématiques, Bioinformatique, Biologie Structurale et Fonctionnelle 4. Informations pratiques Direction des sciences du vivant/Département Réponse et Dynamique Cellulaires Date souhaitée pour le début de la thèse : Oct/nov 2003 |
| Contacts: | 5. Personnes à contacter par le candidat Serge CROUZY BMC/Laboratoire de Biophysique Moléculaire et Cellulaire CEA-DRDC-BMC, 17 rue des Martyrs, 38054 Grenoble Téléphone : +33 4 38 78 48 48 |
| 10/06/2003 | [MM] | Simulation Numérique du Comportement Intracellulaire |
| Source: | http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-104.html |
| Date de parution: | 10/06/2003 | Date limite de réponse: | ? |
| Lieu: | Grenoble (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Proposition de sujet de thèse SL-DSV-03-104 DSV Domaine de recherche Sciences du vivant/Bio-informatique, simulation bio-moléculaire 1. Intitulé du sujet Simulation Numérique du Comportement Intracellulaire Topic tittle Numerical Simulation of Intracellular Behavior 2. Détail du sujet Récemment, il y a une révolution dans la biologie due aux projets génomiques. Le déluge des données produites par ces projets a changé la façon de penser la recherche en biologie et permet des approches novatrices pour aborder les problèmes biologiques. Le projet proposé pour cette thèse se situe dans le domaine de la biologie post-génomique et a pour but ultime la compréhension des réseaux de protéines - comment ils se comportent et les règles générales qui les gouvernent Detailed tittle Recently, there has been a revolution in biology due to the genome projects. The deluge of data produced by these projects has changed the way in which research is done in biology and has led to new approaches to the treatment of biological problems. The project proposed for this thesis falls in the area of post-genomic biology and has as its aim the understanding of protein networks - how they behave and the rules that govern them. 3. DEA recommandés DEAs de Modélisation, de Physique, de Chimie, de Biologie Structurale ou de Biologie Moléculaire 4. Informations pratiques Direction des sciences du vivant/Institut de Biologie Structurale Date souhaitée pour le début de la thèse : octobre 2003 |
| Contacts: | 5. Personnes à contacter par le candidat Martin Field LDM/Laboratoire de Dynamique Moléculaire IBS 41 rue J. Horowitz 38027 Grenoble Téléphone : +33 4-38-78-95-94 |
| 10/06/2003 | [MM] | Computational Chemists/C++ |
| Source: | Bioinformatics.Org |
| Date de parution: | 10/06/2003 | Date limite de réponse: | ? |
| Lieu: | New York (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Salary plus bonus to 150K+ Extraordinarily gifted computational chemists at all levels of experience sought to join a select research group within a rapidly growing New York-based technology firm known for scientific leadership in the development of computational chemistry software for the pharmaceutical and biotechnology industries. We are looking for individuals with an exceptionally distinguished history of academic and/or industrial accomplishment to join our efforts to fundamentally transform the process of drug discovery.Candidates should have world-class credentials in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the computation of protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecular systems, free energy perturbation methods, and methods for speeding up evaluation of electrostatic energies -- but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of activity for the firm include structure- and ligand-based drug design, protein structure determination through homology modeling, molecular mechanics force field development, de novo drug design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations.We are eager to add both senior- and junior-level members to our world-class team (including at least one group head with management responsibilities), and are prepared to offer above-market compensation to candidates of truly exceptional ability. |
| Contacts: | If you are interested send a Word Attachment copy of your resume to the attention of Norm Davis at normd@cisny.com [Please Mention Bioinformatics.Org when replying to this announcement.] Comments? Post your replies to http://bioinformatics.org/forums/forum.php?forum_id=1835 |
| 10/06/2003 | [MM] | development of advanced algorithms for ligand and structure-based drug design and chemical informatics |
| Source: |
| Date de parution: | 06/06/2003 | Date limite de réponse: | ? |
| Lieu: | Exton (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| 3-Dimensional Pharmaceuticals, Inc. (now part of Johnson & Johnson Pharmaceutical Research & Development L.L.C.) is seeking qualified candidates to join the Molecular Design and Informatics group at the Exton, PA and Cranbury, NJ sites. The successful candidates will work on the development of advanced algorithms for ligand and structure-based drug design and chemical informatics. Areas of interest include conformational analysis, protein docking, pharmacophore modeling, 3-D database searching, de novo ligand design, statistical analysis of high-throughput screening results, structure-activity correlation, library design and predictive ADME. Candidates must have a Ph.D. degree in computational chemistry or a related discipline, and must have a strong background in algorithm development and computer programming in one of the areas listed above. Strong C++ programming skills are highly desired, as is the ability to learn new technologies and work effectively in a large development team. Extensive interactions with other informatics and modeling specialists across multiple sites are expected, and will help define long-term needs and solutions for the company's drug discovery projects. Successful candidates must have excellent communication skills and the ability to work in a dynamic, fast-paced team environment. They are also expected to be active in their scientific community through publications, patent filings and presentations at scientific meetings. The Molecular Design and Informatics group at 3DP consists of 18 computational chemists, chemoinformaticians and database analysts, and its mission is to provide modeling and informatics support for the company's internal drug discovery programs, develop new methodologies for computer-assisted drug design, and provide enterprise solutions for Chemical and biological data management. The group has a proven track record of scientific and technical excellence as manifested by its strong publication record, rich patent portfolio, and global impact within R&D, providing a stimulating work environment and great opportunities for scientific growth. Owing to its heritage, our site combines a unique small company atmosphere with the benefits of one of the largest and most admired pharmaceutical companies in the world. |
| Contacts: | Interested candidates should submit their application by e-mail to Dr. Dimitris K. Agrafiotis at dimitris.agrafiotis@3dp.com (see also www.dimitris-agrafiotis.com). For more information, please visit www.jnj.com, www.jnjpharmarnd.com and www.3dp.com. |
| 10/06/2003 | [MM] | SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY |
| Source: | EMBL Job Vacancy 03/21 |
| Date de parution: | 25/05/2003 | Date limite de réponse: | 30/05/2003 |
| Lieu: | Heidelberg (Allemagne) | Statut: | CDD | Secteur: | public |
| Description de l'annonce: |
Laboratoire Européen de Biologie Moléculaire European Molecular Biology Laboratory Europäisches Laboratorium für Molekularbiologie EMBL/V/03/21 rev. May 2003 Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg: SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY Grade: 5 or 6, depending on age, experience and qualifications Duty Station: Hamburg, Germany Commencing Date: As soon as possible after closing date Job Description: The work will involve research, development and/or coding the software modules in the areas of information theory, estimation theory, statistical pattern recognition, neural networks for information reduction and computer learning, independent component analysis - all applied for 3-dimensional image interpretation. The emphasis is on computational techniques. Qualifications and Experience: Programming experience and familiarity with some of the above-mentioned areas are essential. Contract: A contract of 1 year will be offered to the successful candidate. This may be renewed, depending on circumstances at the time of the review. Closing date: 30.05.03 EMBL Web site: http://www.embl.de/ and http://www.embl-hamburg.de Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. |
| Contacts: | To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/21, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany. Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de |
| 10/06/2003 | [MM] | Postdoctorals Fellowships in Structural Molecular Biology at the EMBL Outstation |
| Source: |
| Date de parution: | 25/05/2003 | Date limite de réponse: | ? |
| Lieu: | Grenoble (France) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| The European Molecular Biology Laboratory (EMBL) is an international research organization consisting of a headquarters laboratory situated in Heidelberg Germany and four Outstations. The EMBL Outstation in Grenoble has an active research programme in structural molecular biology and shares a common site with the European Synchrotron Radiation Facility (ESRF) and the Institut Laue Langevin (ILL), world leading centres for X-ray and neutron scattering. We are seeking to recruit postdoctoral fellows with a strong interest in structural biology who can benefit from the juxtaposition of excellent wet-lab facilities with state-of-the-art beamlines for protein crystallography. Depending on the particular laboratory, candidates should either have a background in molecular biology and biochemistry combined with an interest in structural biology or a background in protein crystallography with some experience in molecular biology and biochemistry. Fellowships are available in the following laboratories: Stephen Cusack: Protein/RNA interaction group: the structural basis of protein-RNA recognition in the context of the signal recognition particle and proteins interacting with mRNA or tRNA. e-mail: cusack@embl-grenoble.fr. Rob Ruigrok: Virus structure group: structure and function of viruses and sub-viral assemblies. e-mail: ruigrok@embl-grenoble.fr. Christoph Müller: Protein/DNA interaction group: the structural basis of transcriptional regulation, transcription factor/DNA recognition and the mechanism of nuclear transport. e-mail: mueller@embl-grenoble.fr. Winfried Weissenhorn: Membrane fusion group: the structural basis for viral and cellular membrane fusion processes. e-mail: weissen@embl-grenoble.fr. EMBL is an inclusive, equal opportunity organisation with an exciting and stimulating research environment. |
| Contacts: | Applicants should submit a curriculum vitae, quoting reference no., with concise description of research experience and the names and addresses of at least two referees to: Head of Outstation, EMBL 6 rue Jules Horowitz c/o ILL; B.P. 181; F - 38042- Grenoble Cedex 9, France; Fax: 33-4-76-20 77 86. |
| 10/06/2003 | [MM] | POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY |
| Source: |
| Date de parution: | 25/05/2003 | Date limite de réponse: | ? |
| Lieu: | Heidelberg (Allemagne) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| EMBL Job Vacancy 03/PD/05 Laboratoire Européen de Biologie Moléculaire European Molecular Biology Laboratory Europäisches Laboratorium für Molekularbiologie EMBL/V/03/PD/05 rev. April 2003 Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg: POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY Applications are invited for a postdoctoral fellow position at the EMBL Outstation in Hamburg, Germany. The work will involve development of tools and protocols for assembling, tuning and running software modules, specifically for structure solution, improvement of crystallographic phases, automatic interpretation of electron density maps and assessment of quality of X-ray data and structural models. A background in protein crystallography and interest in methodology is essential. Emphasis will be on computational techniques. Familiarity with computer programming, statistics and mathematical algorithms is advantageous. Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/PD/05, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany. Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de |
| Contacts: | adresse |
| 21/05/2003 | [MM] | computational chemists (multiple positions) |
| Source: | bioinformatics.org |
| Date de parution: | 21/05/2003 | Date limite de réponse: | ? |
| Lieu: | New York (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| The salary range is $100,000 to $150,000(there might be some flexibility) Extraordinarily gifted computational chemists at all levels of experience sought to join a select research group within a rapidly growing New York-based technology firm known for scientific leadership in the development of computational chemistry software for the pharmaceutical and biotechnology industries. We are looking for individuals with an exceptionally distinguished history of academic and/or industrial accomplishment to join our efforts to fundamentally transform the process of drug discovery. Candidates should have world-class credentials in computational chemistry, biology, or physics,or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the computation of protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecular systems, free ener gy perturbation methods, and methods for speeding up evaluation of electrostatic energies -- but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of activity for the firm include structure- and ligand-based drug design, protein structure determination through homology modeling, molecular mechanics force field development, de novo drug design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations. We are eager to add both senior- and junior-level members to our world-class team (including at least one group head with management responsibilities), and are prepared to offer above-market compensation to candidates of truly exceptional ability. |
| Contacts: | If you are interested send a Word Attachment copy of your resume to the attention of Norm Davis at normd@cisny.com |
| 24/04/2003 | [MM] | Computational Chemists |
| Source: | BioJobs |
| Date de parution: | 24/04/2003 | Date limite de réponse: | ? |
| Lieu: | New York (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Extraordinarily gifted computational chemists at all levels of experience sought to join a select research group within a rapidly growing New York-based technology firm known for scientific leadership in the development of computational chemistry software for the pharmaceutical and biotechnology industries. We are looking for individuals with an exceptionally distinguished history of academic and/or industrial accomplishment to join our efforts to fundamentally transform the process of drug discovery.Candidates should have world-class credentials in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the computation of protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecular systems, free energy perturbation methods, and methods for speeding up evaluation of electrostatic energies -- but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of activity for the firm include structure- and ligand-based drug design, protein structure determination through homology modeling, molecular mechanics force field development, de novo drug design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations.We are eager to add both senior- and junior-level members to our world-class team (including at least one group head with management responsibilities), and are prepared to offer above-market compensation to candidates of truly exceptional ability. SALARY $ 100,000- 150,000 depending on experience there is flexibility [Please reference Bioinformatics.Org when replying to this announcement.] |
| Contacts: | Please send your resume (including list of publications, thesis topic, and advisor, if applicable), along with a history of academic performance (including GPAs as well as SAT, GRE, and other standardized test scores), to normd@cisny.com. |
| 24/04/2003 | [MM] | Post-Doctorat au CEA Saclay |
| Source: | BioInfo |
| Date de parution: | 24/04/2003 | Date limite de réponse: | 15/12/2003 |
| Lieu: | Saclay (France) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Titre: Post-Doctorat au CEA Saclay: Simulation moléculaire du transporteurABC bactérien MsbA inséré dans une membrane en vue de modéliser l'action de la Pgp Présentation du laboratoire: Le stage se déroulera au Service de Biophysique des Fonctions Membranaires (DBJC / DSV), dans le cadre d'une collaboration entre le Laboratoire de Biophysique des Protéines et des Membranes et le Laboratoire de Transport Membranaire et Détoxication, au Centre d'Etudes de Saclay (91). Description de la mission proposée: La P-glycoprotéine (P-gp) est un transporteur membranaire actif de détoxication cellulaire appartenant à la grande famille ABC ("ATP Binding Cassette"). Remarquablement multispécifique, la P-gp transporte de nombreux xénobiotiques amphiphiles, et nous venons de montrer qu'elle transporte un lipide membranaire, le cholestérol, vers le feuillet externe de la membrane. La protéine MsbA, transporteur ABC bactérien homodimérique, est très proche de la P-gp en terme d'homologie de séquences. C'est aussi un bon homologue fonctionnel de la P-gp puisqu'elle transporte un lipide létal pour la bactérie. Une structure à haute résolution de MsbA vient d'être publiée. La forme très particulière, "en V" fortement ouvert, du dimère de MsbA est atypique pour une protéine membranaire, et pose le problème de la distribution des lipides autour de la protéine. Déterminer cette distribution permettrait d'avancer vers la compréhension des mécanismes de transport de la MsbA, mais aussi de la P-gp. Seule la simulation moléculaire est actuellement en mesure de fournir une telle information. Nous nous proposons donc d'obtenirpar simulation moléculaire un modèle du système MsbA-membrane, permettant en premier lieu de décrire l'interfacep rotéine-lipide, puis de localiser le site de liaison de son substrat physiologique. L'objectif est de proposer un mécanisme de transport pour ces transporteurs ABC. Ce travail sera effectué en collaboration avec notre équipe de simulation moléculaire. Formation et profil requis: Solide bagage en simulation moléculaire des protéines, avec utilisation des programmes CHARMM (de préférence), ou AMBER, ou GROMACS; bonne connaissance des protéines (plus particulièrement celles associées aux systèmes membranaires) permettant ultérieurement d'aborder la problématique de la modélisation par homologie. Informations générales: Le poste est à pourvoir dès maintenant et avant le 15/12/03. Le contrat proposé est un CDD de 1 an renouvelable une fois. Lieu de travail: Centre d'Etudes de Saclay (RER Le Guichet, près d'Orsay). |
| Contacts: | Procédure de dépôt de candidature: Envoyer par e-mail à Stéphane Orlowski (orlowski@dsvidf.cea.fr) un CV détaillé et une lettre de motivation. Stéphane Orlowski, SBFM / DBJC, Centre d'Etudes de Saclay, 91191 Gif-sur-Yvette cedex. Tel: 01 69 08 95 77; FAX: 01 69 08 81 39. |
| 17/04/2003 | [MM] | Cadre de laboratoire - CDD 18 mois - modelisation moléculaire |
| Source: | ABG-7751 |
| Date de parution: | 14/04/2003 | Date limite de réponse: | 11/05/2003 |
| Lieu: | Chilly Mazarin (91) (France) | Statut: | Postdoc | Secteur: | prive |
| Description de l'annonce: |
| ABG-7751-Cadre de laboratoire - Post Doc CDD 18 mois - modelisation moleculaire - SANOFI-SYNTHELABO - region Paris, France Date de debut de diffusion du poste : 14/04/2003 Date de fin de diffusion prevue : 11/05/2003 SANOFI-SYNTHELABO RECHERCHE offre un poste en CDD (Cadre Post-Doc) de 18 mois (12 + 6 mois) en modelisation moleculaire, au sein de son departement cardiovasculaire-thrombose. Ce departement se consacre a la decouverte de nouveaux medicaments et regroupe des activites de recherche en chimie et en biologie. Poste disponible des le 1 juin 2003. Missions : Le projet innovant concerne l’etude des interactions proteine-proteine et des interactions proteine-ligand via la construction de modeles par homologie et le developpement de methodologies de criblage virtuel. Ce projet impliquera des collaborations multidisciplinaires notamment avec des biochimistes, des biologistes structuraux et moleculaires et des chimistes medicinaux. Qualifications demandees : formation de chimiste ou biochimiste ayant un doctorat en modelisation moleculaire. Experience : La pratique de logiciels de modelisation moleculaire et de chemoinformatique commerciaux (TRIPOS, ACCELRYS, MDL) est recommandee. Lieu de travail : Centre de recherche de Chilly Mazarin (region Parisienne) |
| Contacts: | Merci d'envoyer votre candidature par email a : Dr. Cyril Daveu , Sanofi-Synthelabo Recherche , 1, Ave. Pierre Brossolette , 91385 Chilly Mazarin cedex E-mail : cyril.daveu@sanofi-synthelabo.com Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source(l'Association Bernard Gregory) et la reference ABG de cette offre. |
| 08/04/2003 | [MM] | Computational Chemists |
| Source: |
| Date de parution: | 08/04/2003 | Date limite de réponse: | ? |
| Lieu: | New York (Etats-Unis) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Extraordinarily gifted computational chemists at all levels of experience sought to join a select research group within a rapidly growing New York-based technology firm known for scientific leadership in the development of computational chemistry software for the pharmaceutical and biotechnology industries. We are looking for individuals with an exceptionally distinguished history of academic and/or industrial accomplishment to join our efforts to fundamentally transform the process of drug discovery.Candidates should have world-class credentials in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the computation of protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecu lar systems, free energy perturbation methods, and methods for speeding up evaluation of electrostatic energies -- but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of activity for the firm include structure- and ligand-based drug design, protein structure determination through homology modeling, molecular mechanics force field development, de novo drug design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations.We are eager to add both senior- and junior-level members to our world-class team (including at least one group head with management responsibilities), and are prepared to offer above-market compensation to candidates of truly exceptional ability. |
| Contacts: | Please send your resume (including list of publications, thesis topic, and advisor, if applicable), along with a history of academic performance (including GPAs as well as SAT, GRE, and other standardized test scores), to . SALARY $ 100,000- 150,000 depending on experience there is flexibility. SUBMIT RESUMES TO: Concepts in Staffing ATT: Norm Davis normd@cisny.com |
| 07/04/2003 | [MM] | SOFTWARE ENGINEER / SCIENTIFIC PROGRAMMER IN PROTEIN CRYSTALLOGRAPHY |
| Source: |
| Date de parution: | 07/04/2003 | Date limite de réponse: | 15/05/2003 |
| Lieu: | Heidelberg (Allemagne) | Statut: | CDI | Secteur: | public |
| Description de l'annonce: |
| EMBL/V/03/22 rev. April 2003 Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg: SOFTWARE ENGINEER / SCIENTIFIC PROGRAMMER IN PROTEIN CRYSTALLOGRAPHY Grade: 5 or 6, depending on age, experience and qualifications Duty Station: Hamburg, Germany Commencing Date: As soon as possible after closing date Job Description: The work will involve development of graphical user interfaces (to be built on the existing modules), support of the Web and Email server, support of remote execution of ARP/wARP jobs on local mulit-processor computer cluster. Qualifications and Experience: Applicants should have a computational background and experience in the design of GUI. Profound knowledge of C/C++, Java/Javascript, Perl, Tcl/Tk, HTML or Python programming environments is required. Some familiarity with crystallography will be of advantage. Contract: A contract of 1 year will be offered to the successful candidate. This may be renewed, depending on circumstances at the time of the review. Closing date: 15.05.03 EMBL Web site: http://www.embl.de/ and http://www.embl-hamburg.de Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. |
| Contacts: | To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/22, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany. Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de |
| 07/04/2003 | [MM] | SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY |
| Source: |
| Date de parution: | 07/04/2003 | Date limite de réponse: | 15/05/2003 |
| Lieu: | Heidelberg (Allemagne) | Statut: | CDI | Secteur: | public |
| Description de l'annonce: |
| EMBL/V/03/21 rev. April 2003 Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg: SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY Grade: 5 or 6, depending on age, experience and qualifications Duty Station: Hamburg, Germany Commencing Date: As soon as possible after closing date Job Description: The work will involve research, development and/or coding the software modules in the areas of information theory, estimation theory, statistical pattern recognition, neural networks for information reduction and computer learning, independent component analysis - all applied for 3-dimensional image interpretation. The emphasis is on computational techniques. Qualifications and Experience: Programming experience and familiarity with some of the above-mentioned areas are essential. Contract: A contract of 1 year will be offered to the successful candidate. This may be renewed, depending on circumstances at the time of the review. Closing date: 15.05.03 EMBL Web site: http://www.embl.de/ and http://www.embl-hamburg.de Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. |
| Contacts: | To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/21, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany. Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de |
| 07/04/2003 | [MM] | POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY |
| Source: |
| Date de parution: | 07/04/2003 | Date limite de réponse: | ? |
| Lieu: | Heidelberg (Allemagne) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| EMBL/V/03/PD/05 rev. April 2003 Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg: POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY Applications are invited for a postdoctoral fellow position at the EMBL Outstation in Hamburg, Germany. The work will involve development of tools and protocols for assembling, tuning and running software modules, specifically for structure solution, improvement of crystallographic phases, automatic interpretation of electron density maps and assessment of quality of X-ray data and structural models. A background in protein crystallography and interest in methodology is essential. Emphasis will be on computational techniques. Familiarity with computer programming, statistics and mathematical algorithms is advantageous. Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation. |
| Contacts: | To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/PD/05, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany. Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de |
| 07/04/2003 | [MM] | Post-doctoral Postion in Structural Genomics |
| Source: |
| Date de parution: | 07/04/2003 | Date limite de réponse: | ? |
| Lieu: | Yale (Etats-Unis) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Applicants are invited for a post-doctoral post in the Department of Molecular Biophysics and Biochemistry at Yale University. The position is for two years with possible extensions. Choice of project would to some degree depend on the applicant's interests and abilities, though it is expected that the research will be purely computational and will fall into the emerging field of structural genomics: classifying protein fold families in genomes, developing sequence and structure comparison techniques, and developing databases and analyses for the new genomic information. The ideal applicant would have a PhD (preferably in bioinformatics, biophysics, genetics, or computer science) and have already had some experience in one of the above-mentioned research areas. He or she would be very skilled in programming and using the computer to solve problems (e.g. experience with C/C++, perl5, SQL, HTML/java, fortran, blast/fasta, excel/word, Irix/linux, and so on). |
| Contacts: | Please contact Mark Gerstein for further information (MB&B Department, PO Box 208114, Bass Center, Yale University, New Haven, CT 06520, FAX 203 432 5175, Mark.Gerstein@Yale.edu). Applicants are requested to send a CV that includes a list of publications and details of 3 references. Normal e-mail is OK for all correspondence. However, copies of official documents should follow by regular post. Further details about the position and structural genomics research at Yale can be obtained over the web at: http://bioinfo.mbb.yale.edu/genome. |
| 06/04/2003 | [MM] | Postdoctoral position: Biomolecular NMR and Modelling |
| Source: | Telejob |
| Date de parution: | 06/04/2003 | Date limite de réponse: | ? |
| Lieu: | Zurich (Suisse) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Title of the advert: Postdoctoral position: Biomolecular NMR and Modelling URL: http://www.telejob.ch/telejob/offer.xml?offer=1737 Company: University of Zurich, Institute of Organic Chemistry Workplace: Winterthurerstrasse 190, 8057 Zürich-Irchel Description: Perform NMR-experiments, analyse data, perform modelling studies on peptides. Education: Expertise in biomolecular NMR. The ideal candidate will have a degree in chemistry, or equivalent, and experience NMR-spectroscopy and molecular modelling of peptides and proteins. Entrance Upon: 1. May 2003 Duration of appointment: 12 months with possibility of extension Remarks: Jobsharing possible: no Only for persons notified workless in Switzerland?: no |
| Contacts: | Contact address (for applications): Prof. J. A. Robinson Institute of Organic Chemistry Winterthurerstrasse 190, 8057 Zürich Tel. ++41 1635 42 42/40 Email (for applications): robinson@oci.unizh.ch Link to the company: www.oci.unizh.ch |
| 06/04/2003 | [MM] | Post-doctorants CDD 18 moisINRA |
| Source: | BioInfo |
| Date de parution: | 06/04/2003 | Date limite de réponse: | 15/04/2003 |
| Lieu: | Jouy-en-Josas (France) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| L'INRA recrute 40 post-doctorants sur des contrats à durée déterminée (18 mois) (voir le site http://www.inra.fr/drh rubrique "L'INRA recrute 40 post-doctorants"). Il n'y a aucune condition de nationalité. Les dossiers sont à rendre pour le 15 avril. Notre unité, en collaboration avec l'unité Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA) (également située sur le centre de recherche de Jouy-en-Josas) propose un sujet de post-doctorat ayant trait à la modélisation moléculaire de récepteurs olfactifs (qui sont des récepteurs à 7 segments transmembranaires couplés aux protéines G). Brièvement, il s'agit de modéliser certains récepteurs olfactifs d'intérêt pour l'unité NOPA et de tester la fixation de familles d'odorants sur ces récepteurs par des techniques d'amarrage moléculaire (docking). Les ligands potentiels seront ensuite testés expérimentalement. |
| Contacts: | Pour plus d'information, les personnes intéressées sont priées de me contacter, le plus tôt possible, à l'adresse indiquée ci-dessous. Jean-Francois Gibrat Tel: +33 (1) 34 65 28 97 Mathematique Informatique et Genome, Fax: +33 (1) 34 65 29 01 Institut National de la Recherche Email: gibrat@jouy.inra.fr Agronomique, Domaine de Vilvert, Jouy-en-Josas 78352 cedex, France |
| 06/04/2003 | [MM] | Postdoc position at Johnson & Johnson - virtual screening (VS) in drug discovery |
| Source: | ABG |
| Date de parution: | 07/03/2003 | Date limite de réponse: | 07/04/2003 |
| Lieu: | Val de Reuil (France) | Statut: | Postdoc | Secteur: | prive |
| Description de l'annonce: |
| ABG-7668-Postdoc position at Johnson & Johnson - virtual screening (VS) in drug discovery - Haute Normandie, France Date de debut de diffusion du poste : 07/03/2003 Date de fin de diffusion prevue : 07/04/2003 Johnson & Johnson Pharmaceutical Research & Development, Val de Reuil, France As part of our expanding commitment to virtual screening (VS) in drug discovery, we are seeking a postdosctoral fellow to work in this area. The project will be conducted at the J&J PRD research center in Val de Reuil (Rouen area) under the supervision of Dr Christophe Meyer in charge of the CADD activity. Applicants should have a doctoral degree and previous experience in using computational chemistry methods. Applicants are expected to have a knowledge of the UNIX operating system as well as programming skills. The position requires good communication skills. The appointee will evolve in the J&J international environment including contacts and/or occasional travels in Belgium and the United States. Consequently, a good knowledge of english is strictly required. Applications should contain : a statement of motivation and summary of training and experience; CV and publications list; and names and contact details of 3 referees. Appointment will be on a contract for 2 years with a possible extension of one year. |
| Contacts: | Applications should be e-mailed directly to cmeyer2@prdfr.jnj.com or post-mailed at the following address : Dr Christophe Meyer Centre de Recherche JOHNSON & JOHNSON Campus de Maigremont - B.P. 615 27106 Val de Reuil Cedex - France Tel. (33) 2 32 61 74 60 Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying. |
| 06/04/2003 | [MM] | MdC Bioinformatique moléculaire et structurale |
| Source: |
| Date de parution: | 06/03/2003 | Date limite de réponse: | ? |
| Lieu: | Lyon (France) | Statut: | Maître de Conférence | Secteur: | public |
| Description de l'annonce: |
| Un poste de Maitre de conférences est ouvert à Université Claude Bernard Lyon1 en section 64 avec un profil intitulé "Bioinformatique moléculaire et structurale" MC 0824 64 ème section ENSEIGNEMENT : Filières de formation concernées : DEUG SM DEUGSV, Licence, Maîtrise, DEA de Biochimie Maîtrise de Biologie Moléculaire et Cellulaire (Magistère) Mise en place d'enseignements nouveaux dans le cadre de la réforme LMD RECHERCHE Bioinformatique structurale, modélisation moléculaire, « drug design », séquences et structures de protéines. Laboratoire d'accueil: Institut de Biologie et Chimie des Protéines UMR CNRS 5086 7 passage du Vercors 69367 Lyon cedex 07 Bio - informatique moléculaire et structurales. (http://pbil.ibcp.fr) |
| Contacts: | Contact: Professeur G. DELEAGE Adresse électronique : g.deleage@ibcp.fr Pr. Gilbert DELEAGE http://pbil.ibcp.fr/~deleage Tel +33 (0)4 72 72 26 55 Fax +33 (0)4 72 72 26 04 Pôle BioInformatique Lyonnais Lyon Gerland http://pbil.ibcp.fr Institut de Biologie et Chimie des Protéines 7 passage du Vercors 69367 LYON cedex 7 FRANCE http://www.ibcp.fr |
| 10/02/2003 | [MM] | PhD Position, Computational Molecular Biology |
| Source: | http://www.cnd.mcgill.ca/~swain |
| Date de parution: | 10/02/2003 | Date limite de réponse: | 01/09/2003 |
| Lieu: | Montreal (Canada/Quebec) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| PhD POSITIONS IN COMPUTATIONAL BIOLOGY Centre for Non-Linear Dynamics, McGill University, Montreal. http://www.cnd.mcgill.ca Applications are invited for one or two PhD positions in the area of computational molecular biology at McGill University. This is an exciting, rapidly growing field driven by the recent explosion in quantitative biological data. See Nature 397, 89 (1999). Students will investigate the `design' behind biochemical information processing networks in simple living organisms. We use techniques from stochastic systems, non-linear dynamics, statistical mechanics and Bayesian probability theory. The positions are ideal for students, who have or expect to obtain a good degree in Mathematics or Physics, and are committed to moving into the areas of molecular biology and bioinformatics. The Centre for Non-Linear Dynamics is based around a group of mainly theorists in the department of Physiology. It offers a unique graduate training and is an ideal environment for gaining both modelling and biological expertise. More details are at http://www.cnd.mcgill.ca/~swain |
| Contacts: | Please send/email a CV with the names of two referees to Peter Swain, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6. A probable start date is around September 2003. |
| 06/02/2003 | [MM] | Postdoctoral Position in Protein NMR in Massachusetts |
| Source: | ABGe-1067 |
| Date de parution: | 24/01/2003 | Date limite de réponse: | 24/03/2003 |
| Lieu: | Worcester (Etats-Unis) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| A postdoctoral position is immediately available in the group of Rafael Bruschweiler at Clark University in Worcester, Massachusetts, in the following areas : 1. Development and application of new methods for the rapid determination of protein structures by NMR. This research involves measurement of a variety of NMR parameters and their use in molecular modeling and database methods for the efficient reconstruction of 3D protein structures with application to structural genomics. A related project focuses on the development of new approaches to resonance assignment of proteins with known or homologous structure to assist efforts in high-throughput drug screening. 2. Characterization of side-chain and backbone dynamics of folded and nonfolded proteins by heteronuclear spin relaxation, residual dipolar couplings, and computer simulations. This research aims at the detailed description of the dynamics of proteins under various conditions by combining NMR with computer simulation analysis to obtain better insights on protein function. A dedicated 600 MHz NMR spectrometer is available for this research together with a Linux computer cluster (http://nmr.clarku.edu). Interested candidates should have a strong background in biomolecular NMR or in structural computational chemistry and bioinformatics. Applications should include a curriculum vitae along with names and e-mail addresses of three references. Clark University (www.clarku.edu) is located within commuting distance of Boston. |
| Contacts: | For more information please contact : Prof. Rafael Bruschweiler Carlson School of Chemistry and Biochemistry Clark University 950 Main St. Worcester, MA 01610-1477 U.S.A. Tel. 508-793-7220 E-Mail: bruschweiler@nmr.clarku.edu Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying. |
| 29/01/2003 | [MM] | Mathematicien - Modelisation dynamique en biologie |
| Source: | ABG-7555 |
| Date de parution: | 16/01/2003 | Date limite de réponse: | 25/02/2003 |
| Lieu: | Paris (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Helios Biosciences, jeune entreprise de biotechnologies, lelaureate du 4eme concours creation-developpement d'entreprises innovantes du Ministere de la Recherche,selectionne des cibles therapeutiques pour soigner les maladies neurologiques grace a des modeles dynamiques des reseaux d'interactions moleculaires du systeme nerveux. Le poste concerne le developpement et la mise au point d'un systeme de modelisation de processus biologiques complexes sous la forme de reseaux . Le collaborateur aura pour mission la recherche et la selection l'algorithmes,leur programmation et integration dans le modele, la mise au point et la validation. Notre futur collaborateur, docteur ou ingenieur, aura une formation de haut niveau en Mathematiques, et si possible des notions en biologie. Pour mener a bien sa mission au sein de la societe, il est indispensable que celui-ci ait une bonne competence en algebre et en statistiques (notamment analyse matricielle, theorie des graphes). L'algorithmique de propagation / retro propagation de signaux dans des reseaux sera maitrisee. Autres exigences : autonomie en matiere de programmation, anglais lu et parle, dynamisme et capacites d'initiative (contexte start-up de biotechnologies). |
| Contacts: | Priere de nous envoyer votre CV, votre date de disponibilite et votre souhait de remuneration. Votre contact est : Olivier SOUPAULT olivier@heliobiosciences.com 06 08 69 24 50 Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre. |
| 29/01/2003 | [MM] | Postdoc in COMPUTATIONAL MEDICINAL CHEMISTRY |
| Source: | bioinformatics.org |
| Date de parution: | 29/01/2003 | Date limite de réponse: | ? |
| Lieu: | Salford (Grande-Bretagne) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Applications are invited for a BBSRC-funded post-doctoral position available immediately to work with Dr Sylvie Ducki on a project entitled the Design, Synthesis and Biological Evaluation of Novel Tubulin Ligands. The aim of the project will be to establish a molecular model for the interactions in tubulin-ligand complexes using molecular modelling and docking tools. Candidates should have a postgraduate degree in a molecular modelling related subject or experience in medicinal chemistry together with a proven aptitude for computational work. The position will involve close co-operation with synthetic chemists as well as biochemists therefore applicants should enjoy teamwork and show an active interest in related scientific disciplines. The salary will be on the RA1A scale (£17,626-£26,491) depending on age and experience. The post is available immediately and will be for two years. |
| Contacts: | Interested applicants should submit (for a quick contact use e-mail) a cover letter and a CV to Dr. Sylvie Ducki, (s.ducki@salford.ac.uk) Centre for Molecular Drug Design, Cockroft Building, University of Salford, Salford, M5 4WT, UK. |
| 09/01/2003 | [MM] | Poste CR2 Bioinformatique appliquée à l'analyse des séquences des protéines |
| Source: | BioInfo |
| Date de parution: | 09/01/2003 | Date limite de réponse: | 01/02/2003 |
| Lieu: | Jouy en Josas (78) (France) | Statut: | CDI | Secteur: | public |
| Description de l'annonce: |
| Notre unité Mathématique, Informatique et Génome, centre de recherche de Jouy-en-Josas, Institut National de la Recherche Agronomique, dispose d'un poste de CR2 ouvert au concours en 2003. Pour les renseignements pratiques se référer à l'adresse suivante de la DRH INRA: http://www.inra.fr/drh/cr03/accueil.htm Cliquer sur accès aux profils par concours, puis sur :MM2 Mathématiques appliquées, modélisation, informatique et bioinformatique. Le poste ouvert dans notre unité est : MM2 01 Bioinformatique appliquée à l'analyse des séquences des protéines (PA) Veuillez noter que l'ouverture des inscriptions aura lieu courant janvier et que les dossiers seront à retirer sur le site de la DRH (lire en premier lieu le guide du candidat à un concours de Chargé de Recherche à partir du lien sur la page d'accueil). Notez bien également que la période pour rendre le dossier complet est relativement courte puisque la clôture de dépôt des dossiers aura lieu en février 2003 (la date exacte n'est pas arrêtée pour le moment). Pour plus de renseignements concernant la partie scientifique du profil, veuillez me contacter par téléphone ou par messagerie à l'adresse indiquée ci-dessous. |
| Contacts: | Jean-Francois Gibrat Tel: +33 (1) 34 65 28 97 Mathematique Informatique et Genome, Fax: +33 (1) 34 65 29 01 Institut National de la Recherche Email: gibrat@jouy.inra.fr Agronomique, Domaine de Vilvert, Jouy-en-Josas 78352 cedex, France |
| 02/01/2003 | [MM] | Postdoctoral position in biological NMR spectroscopy |
| Source: | ABGe-1036-Postdoctoral position in biological NMR spectroscopy - |
| Date de parution: | 16/12/2002 | Date limite de réponse: | 15/01/2003 |
| Lieu: | Rochester (Etats-Unis) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| ABGe-1036-Postdoctoral position in biological NMR spectroscopy - Rochester (USA). Date de debut de diffusion du poste : 16/12/2002 Date de fin de diffusion prevue : 15/01/2003 A postdoctoral position is immediately available at the Mayo Clinic and Foundation in Rochester (USA). (www.mayo.edu) Multiple projects involving 3D structure determination and biophysical characterization of protein complexes are available. Please send email for more details. Competitive salary will be determined by the successful candidate's experience. Mayo offers a very attractive benefit package. Mayo Clinic is a not-for-profit organization. |
| Contacts: | send email to : Dr. Georges Mer Mayo Clinic and Foundation Guggenheim 1511B 200 First Street S.W. Rochester, MN 55905 USA Email: mer.georges@mayo.edu Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying. |
| 28/10/2002 | [MM] | Database Mining en Olfaction |
| Source: | ABGt-2323 |
| Date de parution: | 23/10/2002 | Date limite de réponse: | 01/12/2002 |
| Lieu: | Orléans (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| ABGt-2323-Database Mining en Olfaction - Universite d'Orleans Date de debut de diffusion du poste : 23/10/2002 Date de fin de diffusion prevue : 01/12/2002 Une bourse de these est disponible au Laboratoire de Chimiometrie et BioInformatique (CBI) de l'Universite d'Orleans. Cette structure, liee a plusieurs partenaires industriels, travaille sur differentes thematiques concernant la Chimie Medicinale, la biodisponibilite (ADME), la toxicite et l'Olfaction par les methodes de la Modelisation Moleculaire et Database Mining (DBM). Le sujet de these propose consiste a travailler dans le domaine de l'olfaction en exploitant plusieurs techniques DBM innovatrices. Le candidat doit posseder des bonnes connaissances en BioChimie. Une experience en Chimie Informatique, modelisation moleculaire et gestion de bases de donnees constituerait un plus. |
| Contacts: | Les candidats doivent envoyer un CV en format MS Word (avec une photo d'identite jointe), une lettre de motivation et deux references a: Prof. Jacques R. CHRETIEN Lab. Chimiometrie et BioInformatique Universite d'Orleans B.P.6759 45067 Orleans Cedex 2 Email: jacques.chretien@univ-orleans.fr http://iris.univ-orleans.fr et, pour connaissance, a: Dr. Marco Pintore (Directeur Adjoint) Email: marco.pintore@univ-orleans.fr Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre. |
| 11/09/2002 | [MM] | Computational Biology or Bioinformatics |
| Source: | hd-emploi-info |
| Date de parution: | 11/09/2002 | Date limite de réponse: | ? |
| Lieu: | Kyoto (Japon) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| A Post-Doctoral Position in Computational Biology or Bioinformatics in Institute for Chemical Research Kyoto University, Japan A post-doctoral position in computational biology or bioinformatics is available at the Proteome Informatics Laboratory, Institute for Chemical Research, Kyoto University, Japan. The laboratory was established in April 2002 with donations from Silicon Graphics Japan,Ltd. The main objective of the laboratory is to build novel computational approaches for analyzing a variety of subjects related to proteomes. Current application areas of the laboratory include protein-protein interaction, docking between a protein and its ligand, small-molecule similarity, and pathways. The laboratory uses a variety of computational techniques, including algorithmic/thoretical approaches such as approximation algorithms for combinatorial optimization problems as well as machine learning techniques such as active ensemble methods and probabilistic models like finite-mixture models, hidden Markov models, and stochastic grammars. The candidate should have a Ph.D. and solid technical experience in one of the above fields or another field in computer science or a similar quantitative area of study. The applicant should be enthusiastic and energetic in doing new research in proteome informatics and should have sufficient programming skills in C, C++ or Java. The laboratory is well funded, and an excellent research environment will be provided. The position is for one year but renewable, by mutual agreement, until as late as March 2005. Kyoto University's Institute for Chemical Research is located 10 miles south of downtown Kyoto and 25 miles north of the center of Nara, and thus convenient to Japan's two most famous historical cities. The location is ideal for you to both enjoy Japanese traditional beauty and to devote yourself to a new research field, proteome informatics. |
| Contacts: | Please send your detailed curriculum vitae to: Dr. Hiroshi Mamitsuka Associate Professor Institute for Chemical Research Kyoto University Email: mami@kuicr.kyoto-u.ac.jp |
| 10/09/2002 | [MM] | Post-doctoral Computer Programmers in Structural Bioinformatics |
| Source: | http://jobs.ac.uk |
| Date de parution: | 10/09/2002 | Date limite de réponse: | 03/10/2002 |
| Lieu: | Cambridge (Grande-Bretagne) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Post-doctoral Computer Programmers in Structural Bioinformatics Department of Biochemistry Applications are invited for two posts in connection with a collaboration between Cambridge University and Tripos Associates to develop software for fold recognition and comparative modelling. A computer programmer is required to integrate existing software from Cambridge into the Tripos package and to develop new alogrithms. A post-doctoral research associate with knowledge of and experience in bioinformatics is required to develop new approaches in structural bioinformatics. The posts are available up to three years depending on experience and qualifications on the University scale (£17,626 - £26,491). The closing date for applications is 3rd October 2002. The Department operates a no-smoking policy. The University is committed to equality of opportunity. |
| Contacts: | Written applications including CV and names and addresses of two referees should be sent to Mrs B Humphry, Department of Biochemistry, 80 Tennis Court Road, Old Addenbrooke's Site, Cambridge, CB2 1GA, email: bjh32@mole.bio.cam.ac.uk. |
| 05/09/2002 | [MM] | Post Doc en bioinformatique aux NIH, Bethesda, USA |
| Source: | Liste Bioinfo IMPG |
| Date de parution: | 05/09/2002 | Date limite de réponse: | ? |
| Lieu: | Bethesda (Maryland, USA) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| On monte un projet Jean-Francois Gibrat et moi (Unite MIG, INRA) de collaboration avec des collegues du NIH a Bethesda, Maryland, BK Lee (National Cancer Institute) et Peter Munson (Center for Information Technology, CIT). Il s'agit d'analyser et de classer les domaines des proteines de la pdb en utilisant VAST et SHEBA (un programme developpe par BK Lee) de facon a avoir une analyse automatique de la pdb en domaines structuraux. Cela peut servir pour ameliorer le threading et autres types de prediction du repliement des proteines. Un poste de Post Doc, deux ans renouvelables eventuellement est ouvert au CIT, Il faudrait un bioinformaticien ayant un experience en structure des proteines, ou quelqu'un forme en RMN ou radiocristallographie des proteines ayant une experience pratique en programmation. Le lieu est ideal pour ce genre de chose et l'ambiance tres conviviale et scientifiquement tres bon. Le projet va demarrer fin de cette annee, la position est ouverte. |
| Contacts: | Pendre contact avec moi par email (jgarnier@jouy.inra.fr) Jean Garnier INRA - Centre de Recherche de Versailles Unite Mathematique Informatique et Genome RD 10 (route de Saint-Cyr) F-78026 Versailles Cedex, France Tel. : 33.(0).1.30.83.33.67 or 33 51 (sec.) Fax : 33.(0).1.30.83.33.59 |
| 03/09/2002 | [MM] | Chimie-informatique/lead informatics/CRP-VITRY |
| Source: | ABG (ref:ABG-7317) |
| Date de parution: | 03/09/2002 | Date limite de réponse: | ? |
| Lieu: | Vitry (France) | Statut: | CDD | Secteur: | prive |
| Description de l'annonce: |
| The Chemo-Informatics group, Aventis Pharma Paris, has a position open for a dynamic individual with a excellent track records in Chemo-Informatics, Chemometrics, Computational Chemistry and/or Molecular Modeling. In this position you will be expected to invent, develop, and/or implement algorithms, methods and methodologies in one or more of the following areas: knowledge-base reasoning systems, large data set analysis / chemometrics, data mining, automatic pharmacophore perception, physico-chemical and bio-pharmaceutic property predictions, virtual screening and diversity analysis. You will also participate in the design, integration, deployment of software or in-house developed tools associated with drug discove ry. You will closely work with medicinal chemistry, molecular modelling, compound management, screening, drug metabolism and pharmaco-kinetic department, drug-safety department, and information systems. You will closely interact with global and local project teams and with the other informatics groups located on different sites (USA, Germany). This position requires a PhD in Computational Chemistry, or in Molecular Modeling or in Chemometrics with a minimum of one or two years of post-doctoral experience preferably in pharmaceutical industry. Knowledge of Bioinformatics is an asset. Experience in using large database systems (data, 2D, 3D), good programming and scripting skills (C/C++, Java, Perl, Python, VB, SQL, ..), knowledge of Linux/Unix operating environment as well as of commercial drug discovery software is required. A good understanding of medicinal chemistry is highly desirable. Strong interpersonal skills, capacity and enthusiasm for working in an international, multi-disciplinary team as well as in a project managed environment are required. This position is located in Paris (France). |
| Contacts: | For further information please contact Claude Luttmann (claude.luttmann@aventis.com), Phone:+33 1 58 93 38 30, Cell Phone: +33 (0) 6 82 80 92 27 Fax: +33 1 58 93 34 78. Application with CV should be sent to Dr Claude Luttmann, Aventis Pharma, CRP, 13 quai Jules Guesde, BP14, F-94403 Vitry-sur-Seine France Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying. |
| 30/08/2002 | [MM] | Thèse en Modélisation Moléculaire |
| Source: | ABG (ref:ABGt-2203) |
| Date de parution: | 30/08/2002 | Date limite de réponse: | ? |
| Lieu: | Southampton (Grande-Bretagne) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Nous recherchons un doctorant en modélisation moléculaire dans le groupe du Dr. Jonathan Essex à l'Université de Southampton (UK), pour étudier "Le Dévelopement de Méthodes de Calculs d'Energie Libre Rapides appliqué au drug discovery". Cette position est en partie financée par Celltech. Le projet implique le dévelopement et l'application de nouvelles méthodes pour le calcul d'énergies libres de liaison protéine/ligand. Le poste est ouvert a tout candidat citoyen de la CEE, possédant un diplome en Chimie, Physique ou Biochimie. Disponibilité recherchée : immediate Le salaire annuel est de £8000 (~ 12,500 euros) minimum. Le département de Chimie de l'Universite de Southampton est l'un des meilleurs départements de Chimie de Grande Bretagne, il a atteint le grade 5 dans toutes les sections de Recherche. Les thèmes de Recherche du Dr. Jonathan Essex concernent l'application des méthodologies de simulations aux problèmes d'intérêt chimiques et biochimiques. Son travail trouve une application directe dans l'industrie pharmaceutique, avec laquelle il collabore de manière intensive. Il a reçu en 2002 la médaille Marlow de la Royal Society of Chemistry. Plus d'informations sur le groupe du Dr. Jonathan Essex sont disponibles à l'adresse : http://www.soton.ac.uk/~chemphys/jessex |
| Contacts: | Pour déposer votre candidature envoyez un CV ainsi que les noms et emails de deux références, à Mme Jill Queen the University of Southampton (email: jcq@soton.ac.uk, telephone: +44 (0)23 8059 4121). Pour plus d'informations contactez le Dr J.W. Essex jwe1@soton.ac.uk ou www.soton.ac.uk/~chemphys/jessex Merci de préciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la référence ABG de cette offre. |
| 07/08/2002 | [MM] | Several PhD level openings |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 07/08/2002 | Date limite de réponse: | ? |
| Lieu: | Paris (France) | Statut: | Thèse | Secteur: | prive |
| Description de l'annonce: |
| The Department of Informatics at Aventis Paris Research Center has several PhD level openings. If you are interested in working in multicultural pharmaceutical environment at the informatics interface between chemistry and biology and you can offer significant skills, we would like to hear from you. We are looking for qualified candidates in bio- and chemoinformatics for research and/or managerial positions. |
| Contacts: | For further details please contact vladimir.saudek@aventis.com Vladimir Saudek, PhD Director of Informatics France Aventis Pharma Paris Research Center 13 Quai Jules Guesde F-94400 Vitry-sur-Seine France tel : +33 1 5893 2133 tel : +33 1 5893 2504 (secretary) |
| 07/08/2002 | [MM] | Modélisateur moléculaire chez L'Oréal |
| Source: | http://www.ibcp.fr/GGMM/emplois.html |
| Date de parution: | 25/06/2002 | Date limite de réponse: | ? |
| Lieu: | Aulnay (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| MODELISATEUR MOLECULAIRE - Paris -France - (25 juin 2002) Vous ne ressemblez à personne. Bien entendu, vous voulez intégrer une entreprise qui ne ressemble à aucune autre. Imaginez... L'Oréal. Le plus beau portefeuille de marques internationales dans le monde de la beauté, qui s'appuie sur une recherche à la pointe de la technologie. Quelques faits de l'année 2000 : L'Oréal a déposé 420 brevets, lancé environ 450 nouveaux produits, vend 85 produits à la seconde et a plus que triplé son chiffre d'affaires consolidé (12,7 milliards d'Euros) en 10 ans...mais avant tout L'Oréal représente une formidable aventure humaine partagée à travers le monde autour de la beauté, l'innovation et la conquête de nouveaux marchés. L'Oréal recherche un Modélisateur Moléculaire pour son Département Modélisation et Evaluations Rapides. Le poste est basé à Aulnay (93) dans notre Centre International de Recherche Avancée consacré aux Sciences de la Matière. Rejoignez les 2700 chercheurs du Groupe L'Oréal passionnés par la cosmétique et spécialisés dans une trentaine de disciplines scientifiques (chimie, biologie, physique, physico-chimie, biotechnologies , toxicologie, génétique, pharmacie, formulation cosmétique...) au service de nos différents métiers : le capillaire (coloration, soin et hygiène du cheveu, coiffage) et la peau (soin, maquillage, hygiène corporelle, protection solaire, parfums). Rattaché au Responsable Modélisation et Statistique, vous travaillerez en étroite collaboration avec les chimistes de synthèse, à la modélisation et à la conception de molécules originales et innovantes. Votre mission consistera à développer plusieurs modèles structure-activités prédictifs et pertinents permettant de faire des propositions aux chimistes de nouvelles molécules à synthétiser possédant les propriétés cosmétiques et biologiques adéquates. Titulaire d'un Doctorat, vous maîtrisez les méthodes de modélisation moléculaire, en particulier les techniques modernes de QSAR : descripteurs moléculaires 2D et 3D, techniques de sélection des descripteurs pertinents et d'évaluation de la qualité prédictive des modèles structure-activité. Une première expérience (post-doctorale ou industrielle), au cours de laquelle vous avez géré un programme de recherche en collaboration avec des chimistes serait un plus. Par ailleurs vous avez une bonne pratique des logiciels usuels de modélisation moléculaire ainsi que des langages et environnements de programmation informatique, et de bonnes connaissances en chimie. Ouvert, pragmatique et rigoureux, vous avez le sens du travail en équipe pluridisciplinaire. L'Oréal accueille avant tout de fortes personnalités génératrices d'idées. Faire partie de ceux qui imagineront L'Oréal demain : voici votre L'Oréalité ! |
| Contacts: | Postulez en ligne en indiquant le numéro de référence suivant : 223 |
| 07/08/2002 | [MM] | Postdoctoral Positions in Computational Biomolecular NMR |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 30/05/2002 | Date limite de réponse: | ? |
| Lieu: | Yokohama (Japon) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Yokohama, May 30, 2002 Postdoctoral Positions in Computational Biomolecular NMR in the research group of Dr. Peter Guentert Positions for Research Associates at the postdoctoral level are available in the research group of Dr. Peter GYntert at the RIKEN Yokohama Institute in Japan. The research aims at establishing the computational side of automated, high-throughput NMR protein structure determination, and to apply this methodology to systems of key biological and pharamaceutical interest in the context of RIKEN's structural genomics initiative and through collaborations with other research groups. Candidates should have a Ph.D. or equivalent research experience in a relevant area of research. Experience in the fields of NMR spectroscopy, structural biology and scientific computing is important as well as skill in programming and enthusiasm to work in a multidisciplinary environment. RIKEN Genomic Sciences Center provides a stimulating research environment with excellent research facilities, including the world's largest center for biomolecular NMR of currently 18, soon 40 high-field NMR spectrometers. |
| Contacts: | These positions are annually renewable for up to five years. Please submit your application, including a curriculum vitae and two letters of reference, to Dr. Peter Guentert RIKEN Genomic Sciences Center W505, 1-7-22 Suehiro, Tsurumi Yokohama 230-0045 Japan For informal inquiries please contact Dr. Peter Guentert at guentert@gsc.riken.go.jp RIKEN GENOMIC SCIENCES CENTER Dr. Peter Guentert Protein Research Group RIKEN Genomic Sciences Center W505, 1-7-22 Suehiro Tsurumi Yokohama 230-0045 Japan Email : guentert@gsc.riken.go.jp Phone + 81455039345 Fax + 81455039343 |
| 07/08/2002 | [MM] | PostDoc position in Bioinformatics |
| Source: | Bioinformatics.ca - Bioinformatics Jobs |
| Date de parution: | 18/07/2002 | Date limite de réponse: | ? |
| Lieu: | Boston (Massachussets) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Company/Institution: Northeastern University Job Title: PostDoc position in Bioinformatics Required Skills: PhD in biology, structural biology, bioinformatics, physics, computer science, mathematics, statiscits or related disciplines is required. Programming experience for non-computer science applicants (especially C/C++, Java, Perl, SQL) and/or website and database construction are advantage. Job Description: There are several projects available, from protein folding theory to large-scale methods, which also includes protein network and expression data analysis and development and maintenance of innovative web database resource for molecular biology. Work in close collaboration with experimental laboratories. PhD in biology, structural biology, bioinformatics, physics, computer science, mathematics, statiscits or related disciplines is required. Programming experience for non-computer science applicants (especially C/C++, Java, Perl, SQL) and/or website and database construction are advantage. For applicants with computer science degree, knowledge of biology, biochemistry, molecular biology is a plus. The position is for two years with possible extention. Interested applicants should send CV, statement of research interests and the names and addresses of three references to Valentin Ilyin, ilyin@mozart.bio.neu.edu, 414 Mugar, Department of Biology, Northeastern University, Boston, MA 02115. |
| Contacts: | Contact for more information and questions please contact : Valentin Ilyin Northeastern University 414 Mugar, Northeastern University Boston, MA 02115, MA. US Phone: 1-617-373-4031 ilyin@mozart.bio.neu.edu |
| 07/08/2002 | [MM] | Postdoctoral Fellow |
| Source: | Bioinformatics.ca - Bioinformatics Jobs |
| Date de parution: | 21/07/2002 | Date limite de réponse: | ? |
| Lieu: | Ikoma (Japon) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Required Skills: Ph.D (candidates who are about to submit their Ph.D. dissertation will also be considered). Knowledge of Structural Biology, and programming skills, especially in the context of managing and analyzing large data bases. The candidate is also expected to be reasonably skilled in oral and written English. For non-Japanese applicants, a knowledge of Japanese is not a requirement but those who have some exposure to the language will be given preference. Job Description: Two postdoctoral positions are open in the Bioinformatics Unit of the Graduate School on Information Science. The group is fairly new and is supervised by Nobuhiro Go (Professor), Takeshi Kawabata (Associate Professor) and Gautam Basu (Associate Professor). Nara Institute of Science and Technology is situated in the vicinity of Nara city and close to Kyoto and Osaka. The postdoctoral positions are fairly independent and the candidate is expected to launch innovative projects in the field of structural bioinformatics under the close supervision of the group leader. In addition, the candidate is expected to take part in group activities which include development of databases and creating programs that would be widely used by the bioinformatics community. Salary and benefits will be at the level of assistant professor scale of Japanese National Universities. The exact amount will depend on qualifications and experience of the candidate. The initial appointment will be for one year, renewable up to three years. Please send a cover letter describing your interest and qualifications along with (1) Current curriculum Vitae/Resume (2) a full publication list and five reprints (3) Names of two references with full contact information including e-mail address. Screening will begin immediately and proceed until suitable applicants are found. Please visit our website for more details. |
| Contacts: | Send Resume to: gautam@is.aist-nara.ac.jp Contact for more information: Gautam Basu Nara Institute of Science and Technology 8916-5 Takayama Ikoma,JP Phone: +81-743-5616 Fax: +81-743-5617 gautam@is.aist-nara.ac.jp http://nara.aist-nara.ac.jp/index-E.htm |
| 06/08/2002 | [MM] | Bourse de thèse fléchée Inter///Bio |
| Source: | http://germ.cnrs-orleans.fr/annonces.htm |
| Date de parution: | 06/08/2002 | Date limite de réponse: | 17/07/2002 |
| Lieu: | Paris (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Dynamique interne de Biomolécules Grâce à l'utilisation de nouvelles méthodes spectroscopiques de RMN récemment développées au Laboratoire, nous pouvons caractériser les mouvements internes de biomolécules telles que les protéines et leurs complexes. Il est possible de localiser ces mouvements, et notamment de distinguer la mobilité du squelette d'une protéine de celle des chaînes latérales des acides aminés. Nous voulons aussi caractériser les échelles de temps de ces mouvements, qui varient des picosecondes jusqu'aux microsecondes. Directeur de Thèse : Geoffrey Bodenhauden Equipe d'accueil : Laboratoire de Résonance Magnétique Nucléaire, Département de Chimie, ENS Paris Bourse du Ministère : Bourse fléchée qui a été attribuée à ce sujet par l'Ecole Doctorale Inter///Bio. |
| Contacts: | Après consultation avec le Directeur de Thèse, les candidat(e)s devront présenter le sujet devant le jury de l'Ecole Doctorale, probablement entre le 15 et le 17 juillet 2002, en vue de l'attribution définitive de la bourse fléchée à l'un(e) des candidat(e)s. Début de la thèse : Octobre 2002 Contenu Scientifique du programme de Thèse Informations administratives : Renseignements relatifs à l'Equipe d'Accueil Doctorale (EAD) Laboratoire de Résonance Magnétique Nucléaire, Département de chimie, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris 05 Responsable de l'EAD et directeur de thèse: Pr Geoffrey Bodenhausen Téléphone : :01 44 32 33 89 Télécopie : 01 44 32 33 97 E.mail : Geoffrey.Bodenhausen@ens.fr Renseignements relatifs à l'Unité de Recherche Nom et appartenance : UMR 8642 Directeur : Pr Pierre Sinaÿ Téléphone : 01 44 32 33 89 Télécopie : : 01 44 32 33 97 E.mail : Pierre.Sinay@ens.fr |
| 06/08/2002 | [MM] | Contribution à l'annotation structurale du génome de Botrytis cinerea |
| Source: | ED Logique du vivant |
| Date de parution: | 06/08/2002 | Date limite de réponse: | 18/08/2002 |
| Lieu: | Paris (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Introduction: Le séquençage de chaque nouveau génome révèle de nombreuses "orfs" dont la fonction ne peut être déterminée (séquence orphelines). Nous nous proposons d'améliorer les méthodes de reconnaissance de repliements qui peuvent, en association avec des méthodes "humides", permettre d'attribuer une fonction aux séquences orphelines avec plus de sensibilité que PSIBLAST. Nous comptons appliquer ces méthodes dans le cadre de l'annotation de Botrytis cinerea, dont le séquençage est prévu pour 2003. Responsable en particulier de la "pourriture grise" sur la vigne, ce champignon est un phytopathogène nécrotrophe à large spectre d'hôte. Ce caractère d'adaptabilité à l'hôte laisse présager des fonctions non encore identifiées dans les génomes déjà séquencés de levures et de filamenteux. En parallèle, avec les mêmes méthodes, nous nous intéresserons aux duplications structurales. Projet: Les techniques de reconnaissance de repliement par une séquence (« threading ») consistent à mesurer la "compatibilité" d'une séquence de structure inconnue avec toutes les structures protéiques connues, représentées sous formes de "cœurs". Elles nécessitent des techniques de détermination des structures conservées [5,6] dans les familles structurales de protéines afin de constituer la base de "cœurs" structuraux : un cœur est un modèle caractérisant une famille structurale. Ces techniques peuvent fournir des modèles 3D de "travail", utiles dans le domaine de l'enzymologie, mais elles sont surtout de plus en plus utilisées à des fins d'annotation de séquences inconnues, car elles permettent de repérer des similarités qui ne sont pas détectées par les méthodes utilisant seulement l'information de séquence comme BLAST, PSIBLAST ou FASTA. On pourrait parler d'annotation "structurale". Par exemple, sur le génome de Bacillus Subtilis, dans les gènes classés comme orphelins (22% du total des gènes), on peut trouver un repliement similaire à une protéine de structure connue chez 42% de ces orphelins. Nous nous fixons pour buts : 1) d'améliorer la reconnaissance de repliement en développant des programmes de détection de sous-structures communes à plusieurs structures protéiques, afin de redéfinir de manière plus adéquate les "cœurs" de la PDB qui sont utilisés dans les programmes de reconnaissance de repliement (nous développons actuellement un tel programme en collaboration avec A. Marin et J-F. Gibrat, équipe MIG- INRA Versailles[1]). 2) d'appliquer ces méthodes : 2a) pour l'annotation des gènes orphelins de Botrytis cinerea. 2b) pour l'obtention d'un modèle 3D [2,4] de protéines à activité pectinolytique (un travail préliminaire sur ces familles de protéines a été initié en DEA dans l'équipe) 3) d'examiner à l'aide de ces outils de détection de répétitions structurales, les répétitions internes des structures de protéines connues. De manière complémentaire, nous voulons évaluer si les motifs (en séquences) approximativement répétés dans les mêmes gènes [3] présentent des particularités structurales et fonctionnelles, en examinant les structures de protéines connues par cristallographie ou déterminées par reconnaissance de repliement. Annexe: Nous avons participé au Programme "Relations séquence - structure des protéines, entre gènes et fonctions" dans le cadre de l'action Génome du CNRS (1998-2000) pour le "Développement d'une nouvelle fonction et évaluation statistique pour les techniques de reconnaissance de repliements". Nous sommes aussi partie prenante dans deux projets acceptés en cours dans le cadre de l'action "Programme Bio-informatique inter-EPST" CNRS, INSERM, INRA, INRIA, Ministère de la Recherche, (2001-2002). |
| Contacts: | Pierre Netter : netter@ijm.jussieu.fr Joël Pothier : jompo@abi.snv.jussieu.fr Modalités d'attributions de l'allocation |
| 06/08/2002 | [MM] | Biology PhD Student in Bioinformatics Laboratory |
| Source: | Bioinformatics.ca - Bioinformatics Jobs |
| Date de parution: | 18/07/2002 | Date limite de réponse: | ? |
| Lieu: | Boston (Massachussets, USA) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Company/Institution: Northeastern University Job Title: Biology PhD Student in Bioinformatics Laboratory Required Skills: Particularly appropriate are those who have experience in one or more computer languages, C/C++, Java, Perl/CGI, HTML and others, experience with database development and support, MySQL, PostgressSQL, SQL language is a plus. (Molecular ) Biology or biochemistry background is also a plus. Job Description: The Department of Biology at Northeastern University has an opening for a PhD Student in the bioinformatics laboratory. Those who are interested in work on protein theory, protein folding, stability, sequence alignments, structure superposition of proteins and DNA/RNA etc. are welcome to apply. Two types of candidates are appropriate for this field. One is from a natural science field such as biology, biochemistry, molecular biology, chemistry or physics who wish to learn computer and math and the second is from math, statistics and computer science who wish to learn biology. Particularly appropriate are those who have experience in one or more computer languages, C/C++, Java, Perl/CGI, HTML and others, experience with database development and support, MySQL, PostgressSQL, SQL language is a plus. Biology or biochemistry background is also a plus. |
| Contacts: | Send Resume to: ilyin@neu.edu Contact for more information and questions please contact : Valentin Ilyin Northeastern University 414 Mugar, Northeastern University Boston, MA 02115, MA. US Phone: 1-617-373-4031 ilyin@mozart.bio.neu.edu |
| 06/08/2002 | [MM] | Senior Research Scientist |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 06/08/2002 | Date limite de réponse: | 31/07/2002 |
| Lieu: | Gif sur Yvette (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| BIO-XTAL is a biotechnology company dedicated to protein structure determination through X-ray crystallography. We provide services in the field of molecular biology, from protein purification to structure determination. BIO-XTAL is currently at the head of an ambitious research project in the field of GPCR (G-protein coupled receptors) structural determination. This consortium includes 4 European academic labs and 42 companies (including major pharmaceuticals companies such as GlaxoSmithKline, AstraZeneca, Roche...). Head of Protein Crystallography Department Mission: We are seeking a Senior Research Scientist to lead our service activity covering all aspects of crystallography studies and more especially high throughput crystallogenesis. The ideal candidate should have a strong background in biochemistry, crystallogenesis and expertise in protein structure determination by X-ray crystallography. This individual should have managerial and commercial experience while possessing excellent communications skills. The candidate should enjoy challenges, be rigorous and enjoy working in a team. A good knowledge of English language is a pre-requisite. The successful candidate will work in a new laboratory based in Gif-sur-Yvette (France). Location : Gif-sur-Yvette (South-West of Paris) Salary: The remuneration offered will depend both on the range and depth of experience. Closing date for applications: July 2002. The position must be filled as soon as possible. |
| Contacts: | Please send a full CV and handwritten application letter to: Dr. Jean-François Tétu Bio-Xtal 4 rue de la Noue 91190 Gif-sur-Yvette - France Or via electronic mail to: jftetu@bioxtal.com |
| 30/07/2002 | [MM] | Head of Molecular Modelling |
| Source: | La Toile des Biologistes (http://www.ujf-grenoble.fr/biotoile) |
| Date de parution: | 30/07/2002 | Date limite de réponse: | ? |
| Lieu: | Centre de la France (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Location Central France Excellent remuneration package The Company: A private, medium size, fully integrated R&D pharmaceuticals company established over a century ago with a strong presence and pipeline of compounds in therapy areas including cardiovascular, lipids and inflammation. The Position : This is a new role within the company, heading up a sizeable team based within the IT department but fully integrated in and supporting discovery research through working intimately with bioinformatics, chemistry and biology. Responsibilities include: - Building, establishing and leading the molecular modelling (and perhaps cheminformatics) team as a prime resource within the drug discovery process. - Providing computational chemistry support across the company's drug discovery projects. - Manage the budget for molecular modelling / computational chemistry. - Being the company's expert in molecular modelling / cheminformatics. The Candidate : The nature of the role demands the skills set of an experienced, confident professional with strong interpersonal skills and management background, whose credentials closely match the following parameters: - Educated to PhD or equivalent level in the life sciences or information technology. - Over 5 years experience in computational chemistry within drug discovery in the pharmaceuticals industry. - In depth understanding of drug discovery, drug design and how to build in drug-like characteristics into molecules. - Proven line and matrix management skills. Summary: This role presents an excellent opportunity for a specialist in computational chemistry to work within a medium size organisation with minimal bureaucracy where, leading a sizeable team, he/she can have a profound influence on the strategy and operations within drug discovery. |
| Contacts: | For further information please contact : Dr James Sherifi Tel: +44 (0) 1223 235333 Fax: +44 (0) 1223 209519 jamessherifi@euromedica.com Boris Bouqueniaux Tel: +44 (0) 1223 209509 (Direct) Fax: +44 (0) 1223 209519 borisbouqueniaux@euromedica.com |
| 24/07/2002 | [MM] | PhD in Bioinformatics/Computational Biochemistry |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 24/07/2002 | Date limite de réponse: | 15/08/2002 |
| Lieu: | Norwich (Grande-Bretagne) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Studentship School of Information Systems Applications are invited for a PhD in Bioinformatics/Computational Biochemistry at the University of East Anglia. The postholder will undertake research on the EPSRC project "Understanding Protein Domain Motions through Simulation with a Focus on Citrate Synthase". The supervisor will be Dr Steven Hayward. Background Proteins are molecular machines designed to carry out specific tasks. For a large number of proteins, their structure and function is known, but the key question remains largely unanswered: what is the relationship between structure and function? The study of protein dynamical behavior will provide the answer to this question, but experimental techniques do not gives us a complete picture of the processes occurring at the atomic level. The computational technique of molecular dynamics simulation presents an atomic level description of protein dynamical behavior and has recently provided us with some important insights [1]. The aim of the project will be to understand the detailed mechanisms of domain closure in enzymes by making comparisons between experimentally determined functional movements in domain proteins and results from molecular dynamics simulations. The project will utilise information stored in the new DynDom database of protein domain movements (see http://www.sys.uea.ac.uk/dyndom ) which is being developed in a bioinformatics approach to understanding and predicting functional movements in proteins[2]. The research project will build upon our recent simulation study of the enzyme citrate synthase[3]. References [1]H.J.C. Berendsen, S.Hayward, "Collective protein dynamics in relation to function", Current Opinions in Structural Biology, 10 (2), 165, 2000. [2] S.Hayward,"Structural Principles Governing Domain Motions in Proteins", Proteins, Structure, Function and Genetics, 36, 425, 1999. [3]D.Roccatano, A.E.Mark and S.Hayward,"Investigation of the Mechanism of Domain Closure in Citrate Synthase by Molecular Dynamics Simulation",J. Mol. Biol., 310, 1039, 2001. To apply you should have or expect to be awarded a First or Upper Second Class Honours degree or MSc in an appropriate discipline. The studentship is sponsored by EPSRC and is offered at the rate of £8,000 per year for three years, plus tuition fees. The post is available from October 2002. |
| Contacts: | Further information may be obtained from Dr Steven Hayward, Tel: 01603 593542 or e-mail: sjh@sys.uea.ac.uk To apply please send a CV, covering letter and names/addresses of two academic referees to: Ms C. Bramwell, Research Administrator, School of Information Systems, University of East Anglia, Norwich NR4 7TJ. Applications via email are not permitted. |
| 24/07/2002 | [MM] | Post-Doctoral Research Fellow in Protein Folding |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 24/07/2002 | Date limite de réponse: | 16/08/2002 |
| Lieu: | Leeds (Grande-Bretagne) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| School of Biochemistry and Molecular Biology ASTBURY CENTRE FOR STRUCTURAL MOLECULAR BIOLOGY This post is available immediately for a fixed term of two years in the first instance, with the possibility of an extension of twelve months. You will join a dynamic collaborative team led by Professor Radford (School of Biochemistry and Molecular Biology) and Dr Smith (Department of Physics and Astronomy). Working within this interdisciplinary environment, you will use molecular biology and kinetic methods to study the structure and folding mechanisms of proteins. The project will include protein redesign, structural studies and kinetic analysis of folding using stopped flow as well as novel rapid methods of studying folding. You must have a PhD in biochemistry, chemistry or a related discipline. Salary: Research IA (£17,626 –26,491 p.a.) Information about the activities of the supervisors and their groups are on the web at http://www.astbury.leeds.ac.uk. |
| Contacts: | Informal enquiries by email to: Professor S Radford: s.e.raford@leeds.ac.uk or Dr D Smith: d.a.m.smith@leeds.ac.uk Application packs from: Mrs. D. Baldwin, School of Biochemistry and Molecular Biology, University of Leeds, Leeds LS2 9JT. Tel: 0113 343 3112, email: D.Baldwin@leeds.ac.uk or on the web at http://www.astbury.leeds.ac.uk. |
| 22/07/2002 | [MM] | These en chem-informatique / bio-informatique |
| Source: | ABG (ref:ABGt-2123) |
| Date de parution: | 15/07/2002 | Date limite de réponse: | 12/09/2002 |
| Lieu: | Illkirch (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Cette thèse s’inscrit dans le cadre du génopole Alsace-Lorraine ("Du gène au Médicament") et des thématiques de l’IFR-85 Gilbet Laustriat (Récepteurs couplés aux Protéines G) afin de faciliter la découverte de nouveaux candidats médicaments à partir de cibles génomiques originales. Résumé du sujet de recherche: Cette étude vise a développer une méthode bioinformatique originale dont le but est la conception focalisée de ligands (chimiothèques) de RCPGs, qui représente la famille de cibles thérapeutiques la plus importante du génome humain. Profil du candidat recherché : - Formation : DEA (nécessaire) en chimie théorique, chimie-informatique, bio informatique, ou informatique - Connaissances de bases en chimie-physique théorique - notions de modélisation moléculaire - aptitude à la programmation (C, C++, perl, java) - facilité d’adaptation à un travail dans un environnement pluridisciplinaire. |
| Contacts: | contacter: Dr. Didier ROGNAN : Equipe de Bioinformatique, UMR 7081, Pharmacochimie de la Communication Cellulaire, 67400 Illkirch Tél : 03.90.24.42.35, e-mail : didier.rognan@pharma.u-strasbg.fr Merci de préciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la référence ABG de cette offre. |
| 18/07/2002 | [MM] | Enzyme Function And Reaction Mechanisms: Computational Studies |
| Source: | ABG (ref:ABGe-879) |
| Date de parution: | 16/07/2002 | Date limite de réponse: | 16/09/2002 |
| Lieu: | Cleveland (Ohio, USA) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| A postdoctoral position is open at Cleveland State University (Ohio -USA) for 2 years (with possible extention for another year). Different projects are proposed in collaboration with Cleveland Clinic: 1) NOS enzyme 2) Reaction mechanism of Cl- oxidation to Cl+ by myeloperoxydase 3) Modeling the AT1 receptor 4) Activity of Factor V (blood coagulation cofactor). In close collaboration with experimentalists our main tools used for these projects are molecular modelling, QM/MM approaches and MD simulations. The salary is very attractive depending on condidate experience. You should hold a Ph.D. or equivalent degree in biochemistry, biophysics, chemistry or physics or a related discipline. Very motivated scientist willing to work in a multidisciplinary team and a previous experience with computational methods is appreciable but not a requirement. |
| Contacts: | For application please send or email your CV + at least 1 recommendation letter to : Dr. A. ABABOU NMR Center (MSB) Leicester University University Road Leicester LE1 9HN UK phone: 44 (0) 116 223 3071 fax: 44 (0) 116 223 1503 e-mail: aa116@le.ac.uk Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying. |
| 17/07/2002 | [MM] | Two Postdoctoral Fellowships - Machine Learning and Bioinformatics |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 20/06/2002 | Date limite de réponse: | 31/07/2002 |
| Lieu: | Londres, Californie (Grande Bretagne, USA) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| We are seeking two highly creative and motivated postdoctoral research fellows to participate in the following research area: Development of Bayesian network models and machine learning methods for protein fold recognition. This project is part of a collaborative effort to develop a community resource to enable the emerging science of structural genomics. Candidates should have a Ph.D. in computational biology, computer science, machine learning, theoretical physics, applied mathematics, or a similar quantitative field and a strong interest in molecular biology. The positions will be based in London (position 1) and Southern California (position 2), and are described below. The positions form part of a collaborative research project between KGI, UCL, UCSD and the Burnham Institute. Position 1 ---------- Gatsby Computational Neuroscience Unit, University College London (UCL) http://www.gatsby.ucl.ac.uk/ Working with Dr Zoubin Ghahramani on advanced inference and learning methods in Bayesian networks and other statistical machine learning methods with applicability to protein fold recognition. The Gatsby Unit at UCL is located in a quiet square in the heart of London, providing an ideal setting for research in computational neuroscience and machine learning in an exciting urban environment. Position 2 ---------- Keck Graduate Institute in Applied Life Sciences (KGI) http://www.kgi.edu/home.html Working with Dr David Wild on the application of machine learning methods to protein fold recognition. KGI is located 35 miles east of Los Angeles, at the foot of the San Gabriel Mountains. Its campus is contiguous with those of the other Claremont Colleges, which together with surrounding educational institutions in Southern California provide a rich intellectual and cultural environment. |
| Contacts: | Position1: Prospective candidates should apply with a cover letter, CV, and names and email addresses of 2-3 referees. This should be sent by email to: admin@gatsby.ucl.ac.uk, preferably using plain text, postscript or pdf formats only. Closing Date for applications: 31 July 2002. The position is available immediately and the duration of the appointment is 2 years with possibility of renewal. Position 2: Prospective candidates should apply with a cover letter and CV, and ask for at least two letters of recommendation to be sent to Dr. David Wild at: Keck Graduate Institute, 535 Watson Drive, Claremont, CA 91711. Email: david_wild@kgi.edu. The position is open immediately and applications will be reviewed as they are received until the position is filled. |
| 17/07/2002 | [MM] | Enhancing Molecular Docking Through High-Performance Computing and Advanced Visualization |
| Source: | Liste Bioinfo IMPG |
| Date de parution: | 17/07/2002 | Date limite de réponse: | 30/08/2002 |
| Lieu: | Nancy (France) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| We have an opening for a post-doctoral fellow for up to 2 years, commencing september/october 2002 or later, to work on: Enhancing Molecular Docking Through High-Performance Computing and Advanced Visualization Molecular docking is the natural process by which molecules recognize and interact with one another. From a computational standpoint, it also refers to the prediction of the structures of ligand-receptor complexes from the conformations of unbound ligand and unbound receptor. Molecular docking is at the center of such practical applications as protein engineering and drug design. It has already helped to design new ligands for anti-AIDS and anti-cancer agents and for the treatment of diabetes. Structure-based molecular docking programs are based on the assumption that ligands which form favorable interactions with the receptor must have high binding affinity. They rely on the number-crunching capabilities of computers to generate and evaluate large numbers of possible bindings. Computers however do not have the experience of human beings and molecular docking methods severely limit the biochemists' ability to analyze the bindings computed and exploit their intuition and expertise to generate sound and reliable solutions. Also, most approaches to molecular docking do not take advantage of the visualization capabilities offered by modern workstations. Major challenges in this field are (1) predicting how molecules will dock with one another and (2) identifying the factors that determine the specificity of interaction. To make significant advances, it is necessary to develop novel methods to facilitate the docking techniques by enhancing our ability to understand and analyze docking interactions and to develop hypotheses about which molecules are most likely to interact favorably. These factors can be incorporated into molecular docking by including advanced visualization and haptic (sense of touch) feedback in the process. The main goal of this project is to develop an immersive, interactive and easy-to-use modelling environment to enhance molecular docking. The candidate will have at its disposal the state-of-the-art SGI high-performance computing technologies available at LORIA, notably the Reality Center immersive visualization facility and the Onyx 3800 shared-memory system platform. In particular, the postdoctoral candidate is expected: - To integrate existing molecular docking programs with the LORIA collaborative computing environment. - To implement a haptic interface to facilitate interaction with molecular models, through a high-fidelity, 3D force-feedback device. - To combine visualization and haptic feedback to allow interactive docking simulations in the Reality Center. - To develop a multimodal user interface to facilitate the work of molecular scientists. The successful candidate will have a solid background in SGI graphics software and architecture. He is also expected to have a working knowledge of programming and scripting languages such as Java, Perl and TCL/TK.Candidates having experience in parallel computing and/or grid computing will be given priority. Salary will be approximately 21400 euros per annum. There are no restrictions on the nationality of the applicant. |
| Contacts: | For more information on this position as well as indication of interest, please contact Bernard Maigret (Bernard.Maigret@lctn.uhp-nancy.fr) http://www.lctn.uhp-nancy.fr or Sylvain Petitjean (Sylvain.Petitjean@loria.fr) http://www.loria.fr |
| 14/06/2002 | [MM] | Postdoctoral Research Fellow |
| Source: | Bioinformatics |
| Date de parution: | 14/06/2002 | Date limite de réponse: | ? |
| Lieu: | Basel (Suisse) | Statut: | Postdoc | Secteur: | prive |
| Description de l'annonce: |
| Firma/Name: Biozentrum & Swiss Institute of Bioinformatics Stichwoerter: Bioinformatics, Protein Structure Modeling Beschreibung: A postdoctoral position is immediately available in the Structural Bioinformatics group at the Biozentrum (University of Basel & Swiss Institute of Bioinformatics). We are looking for a talented scientist interested in computational protein structure modeling, development of the SWISS-MODEL server and related databases. Ausbildung: Candidates should have a strong background in biophysics or computational life sciences. Experience in any of the following areas would be highly appreciated: structural biology, statistics, biochemistry, molecular dynamics, programming in Unix environments (C, Perl). Antritt: The position is available immediately. Bemerkungen: The Biozentrum (University of Basel) and the Swiss Institute of Bioinformatics offer competitive academic salaries, a state of the art computing infrastructure and an intellectually stimulating multinational research environment. |
| Contacts: | Kontakt Adresse: Prof. Torsten Schwede Biozentrum & Swiss Institute of Bioinformatics University of Basel Klingelbergstrasse 50-70 CH-4056 Basel / Switzerland Torsten.Schwede@unibas.ch Link auf die Firma: http://www.biozentrum.unibas.ch/schwede/ Stellen Nummer: 1021459169_303631 |
| 11/02/2002 | [MM] | Professor/Reader/Senior Lecturer/Lecturer in Structural Biology and Bioinformatics |
| Source: | Ph. Marc (Agm2) - jobs.ac.uk |
| Date de parution: | 11/02/2002 | Date limite de réponse: | 13/03/2002 |
| Lieu: | Londres (Grande-Bretagne) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Professor/Reader/Senior Lecturer/Lecturer in Structural Biology and Bioinformatics (2) Faculty of Science School of Crystallography Opportunities for structural biologists and bioinformaticians within School of Crystallography have arisen from the secondments of Professor Janet Thornton (Head of European Bioinformatics Institute) and Professor Julia Goodfellow (Chief Executive of the BBSRC). The School is internationally renowned for its research and postgraduate teaching, with excellent facilities for protein crystallography, cryo-electron microscopy, spectroscopy and computing. It also has a strong programme in Materials Science. It is a major partner in the Bloomsbury Centre for Structural Biology, and in a Joint Research School with the Department of Biochemistry and Molecular Biology of University College, London. The posts are tenable from 1 September 2002. Applicants for appointment at senior level should have an international reputation for outstanding research and a distinguished publication record in a relevant area (a strong interest in crystallography, genomics or computational biology would be especially welcome). For a lectureship, applicants should have a PhD in a relevant subject and postdoctoral research experience. Salary range (effective from 1 March 2002): Professor - negotiable but not less than £41,528 pa inc; Reader/Senior Lecturer - £36,292 to £40,737 pa inc; Lecturer - £21,815 to £34,671 pa inc, depending on qualifications and experience. Closing date: 13 March 2002 (Ref: ACR102) Download the job description and application form by clicking on ‘Further details’ below OR Email personnel@bbk.ac.uk OR send a large (A4) sae quoting the reference number to the Personnel Department Birkbeck, Malet Street, Bloomsbury, London WC1E 7HX. Further details |
| Contacts: | Click here for Employer Profile |
| 07/02/2002 | [MM] | PhD Project Studentship |
| Source: | Ph. Marc (Agm2) |
| Date de parution: | 07/02/2002 | Date limite de réponse: | 31/03/2002 |
| Lieu: | Aberdeen (Ecosse) | Statut: | Postdoc | Secteur: | public |
| Description de l'annonce: |
| Searching Small Molecule 3D Databases using Spherical Polar Fourier Correlations Department of Computing Science An EPSRC-funded PhD studentship is available for a period of three years, starting in April 2002. One of the key challenges in the pharmaceutical industry is to identify potential drug molecules. A number of chemical databases exists which contain several hundred thousand three-dimensional molecular structures. We believe this wealth of structural information could be better exploited by using improved methods of searching for similar three-dimensional structures and sub-structures. The aim of this project is to apply and extend our successful spherical polar Fourier correlation technique for protein docking (see http://www.csd.abdn.ac.uk/~dritchie) to the molecular similarity problem domain, in order to develop a new computational method of searching chemical structure databases for novel pharmacological molecules. Candidates should have, or expect to obtain, a first or upper second class degree in one of the physical sciences and should have an interest in scientific programming. Applications from biological scientists with strong computing skills will also be welcomed. The studentship provides a maintenance grant of £8000 per annum (tax free), and includes all tuition fees for UK/EU students. Non-EU students may also apply, but would be expected to provide the difference between international and UK tuition fee rates. |
| Contacts: | Applicants should send completed application forms (available at: http://www.csd.abdn.ac.uk/pgstudy) along with a detailed CV to Dr Dave Ritchie, Computing Science Department, University of Aberdeen, Aberdeen AB24 3UE, Scotland, UK. Informal enquiries may be addressed to dritchie@csd.abdn.ac.uk, telephone +44 1224 272282. |
| 12/07/2001 | [MM] | Bourse Mobilité |
| Source: | Charlotte Boschet (présidente Asso) |
| Date de parution: | 12/07/2001 | Date limite de réponse: | 16/07/2001 |
| Lieu: | Paris (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Anne Imberty (cermav) a une (ou plus) bourse(s) à mobilité en biologie structurale (modélisation, cristallisation des lectines). Le dossier est à rendre pour lundi 16 juillet 2001 |
| Contacts: | imberty@cermav.cnrs.fr breton@cermav.cnrs.fr TEL: 04 76 03 76 35 |
| 03/07/2001 | [MM] | ATER Physico-Chimie moléculaire et cellulaire au Muséum National d'Histoire Naturelle |
| Source: | lettre d'information de l'iEDU |
| Date de parution: | 03/07/2001 | Date limite de réponse: | 03/09/2001 |
| Lieu: | Paris (France) | Statut: | ATER | Secteur: | public |
| Description de l'annonce: |
| Avis de vacance d'emplois d' A.T.E.R. au Muséum National d'Histoire Naturelle : Une circulaire est envoyée, ce jour, pour affichage, à tous les Directeurs de Laboratoire et Chefs de service. 10 emplois sont ouverts au Muséum : 2 postes en Biologie des populations : Intitulés des profils : - Dynamique des Populations d'oiseaux - Dynamique des communautés d'oiseaux 4 postes en Biologie des organismes : Intitulés des profils : - Technologies de la reproduction appliquées à la conservation d'espèces en voie de disparition ( Parc de la Haute Touche à Azay) - Biologie de la conservation des plantes (Conservatoire botanique national du Bassin parisien à Cherré (Sarthe) - Phylogénie des Téléostéens (Laboratoire d' Ichtyologie générale et appliquée) - Biologie et Biotechnologies Marines (Station de Biologie Marine de Concarneau) 2 postes en Sciences de la Terre : Intitulés des profils : - Préhistoire et paléoenvironnements du Quaternaire, Pléistocène supérieur (Abri Pataud) - Modélisation hydrosédimentaire et biologique d'écosystèmes côtiers macrotidaux (Laboratoire d'Océanographie Physique) 2 postes en Biologie expérimentale : Intitulés des profils : - Endocrinologie évolutive (Laboratoire de Physiologie) - Physico-Chimie moléculaire et cellulaire Les dossiers sont à retirer à l'Administration - service du Personnel - où ils devront être retournés, au plus tard, le 3 septembre 2001, délai de rigueur, (le cachet de la poste faisant foi). |
| Contacts: | le telephone standart ( 01.40.79.30.00), serveur : http://www.mnhn.fr |
| 01/07/2001 | [MM] | Caractérisation de signatures complexes pour la découverte de nouveaux membres dans des familles de protéines connues. |
| Source: | liste bioinfo IMPG |
| Date de parution: | 19/06/2001 | Date limite de réponse: | ? |
| Lieu: | Nantes (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Proposition de sujet de thèse pour la rentrée 2001/2002 Rénumération: 6100 fr net/mois sur 3 ans Laboratoires - Equipes : (1)INSERM U463, Institut de Biologie 9 Quai Moncousu, F-44035 Nantes cedex (2)IRIN, Equipe C.I.D., Ecole polytechnique de l'université de Nantes, Rue Christian Pauc BP 50609 44306 Nantes cedex 3 Description du sujet : Une application importante de la bioinformatique concerne la recherche de nouveaux membres d'une famille de protéines connues. Une technique classique procède par la découverte de motifs conservés dans cette famille, puis par l'interrogation de bases de données pour l'identification de gènes putatifs homologues à ce motif. Cette technique devient assez aléatoire lorsque la famille de protéines est très large et que les motifs y sont peu conservés. Cette approche, basée uniquement sur la structure primaire des protéines, étant insatisfaisante, nous envisageons de nous pencher sur la structure secondaire qui est bien identifiée dans le cas des cytokines. Nous savons en effet qu'elle est caractérisée par quatre hélices alpha de tailles et de positions comparables au sein de la séquence protéique. L'idée est donc de modéliser la famille de protéines par une connaissance multi-niveaux, intégrant les aspects primaires et secondaires. Cette étude nécessite donc d'extraire les paramètres les plus représentatifs d'une famille de protéines, en utilisant les algorithmes de découverte de motifs et de prédiction de structures secondaires. En second lieu, il s'agit de développer des techniques d'extraction de connaissances pour trouver les règles de caractérisation les plus pertinentes de cette famille. La finalité de ce travail est de pouvoir prédire l'appartenance d'une protéine à la famille modélisée, en se basant sur des indices de niveau primaire (succession de motifs de petites tailles dans la séquence) et de niveau secondaire (présence d'hélices alpha à des positions similaires). On utilisera les éléments connus de la famille pour tester cette approche, en découpant la famille en deux jeux ; un jeu de références et un jeu de test. Ce travail s'intègre dans un effort de développement d'un outil d'aide à l'identification de nouveaux membres (requêtes automatiques, assemblage et analyse de cadres ouverts de lecture). |
| Contacts: | Yannick Jacques(1), tel : 02.40.08.47.23, mél: yjacques@nantes.inserm.fr Gérard Ramstein(2), tel : 02.40.68.30.16 mél: gerard.ramstein@polytech.univ-nantes.fr |
| 01/07/2001 | [MM] | Researcher – Protein structure modelling NAUTILUS BIOTECH |
| Source: | http://www.arborescience.com/public/pages_fr/jobs_detail.php?id=1413 |
| Date de parution: | 25/05/2001 | Date limite de réponse: | ? |
| Lieu: | Evry (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Description du poste à pourvoir : Job Description: Modelling of protein structure, folding, active sites/domains and ligand/protein-protein interaction. Place : Evry, France Compensation package: -Highly competitive salary -Stock options according to personal and Company performance Position available immediately Requirements: PhD in Biology, Biotechnology or similar Previous experience in modelling of protein structure |
| Contacts: | Contact : Contact information: Manuel Vega CEO mvega@nautilusbiotech.com tel : +33 (0)6 87 69 56 38 Référence de l'offre, pour votre candidature et dans toute correspondance avec Arborescience : ARB1413 |
| 01/07/2001 | [MM] | ABG-6416 - Position postdoctorale en Modelisation Moleculaire |
| Source: | association Bernard Gregory |
| Date de parution: | 01/07/2001 | Date limite de réponse: | ? |
| Lieu: | Fresnes (France) | Statut: | Postdoc | Secteur: | prive |
| Description de l'annonce: |
| ABG-6416 - Position postdoctorale en Modelisation Moleculaire (industrie phamaceutique) Date de debut de diffusion du poste : 18/06/2001 Au sein du Departement Sciences Pharmaceutiques de notre Centre de Recherche, ce post-doc integrera une equipe de physico-chimistes et de formulateurs pour un Contrat post-doctoral d'une duree de 12 mois. Il aura pour mission de relier des etudes conformationnelles a certaines proprietes physico-chimiques . Pour cela, il devra realiser des analyses conformationnelles sur petites molecules (principes actifs) en milieu solvant, en utilisant les logiciels MSI, Tripos (Sybyl 6.6)... Les candidats doivent etre titulaires d'un Doctorat en Chimie / physico-Chimie avec une specialisation en modelisation moleculaire. Nous vous remercions d'adresser CV + lettre de motivation a : PFIZER Global Research & Development A l'attention de Joel Vacus Departement Sciences Pharmaceutiques 3/9 rue de la Loge BP 100 94265 FRESNES Cedex Tel: 01 40 96 74 00 / joel.vacus@pfizer.com Precisez dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre. Merci de nous informer des suites donnees a votre candidature sur ce poste, si ces suites sont positives et aboutissent a votre recrutement (E-mel: alain.valette@abg.asso.fr) |
| Contacts: | Nous vous remercions d'adresser CV + lettre de motivation a : PFIZER Global Research & Development A l'attention de Joel Vacus Departement Sciences Pharmaceutiques 3/9 rue de la Loge BP 100 94265 FRESNES Cedex Tel: 01 40 96 74 00 / joel.vacus@pfizer.com Precisez dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre. Merci de nous informer des suites donnees a votre candidature sur ce poste, si ces suites sont positives et aboutissent a votre recrutement (E-mel: alain.valette@abg.asso.fr) |
| 01/07/2000 | [MM] | deux bourses de thèses à pourvoir. Contexte scientifique : Bioinformatique et Génome |
| Source: | transmis par Philippe Dessen |
| Date de parution: | 17/07/2000 | Date limite de réponse: | ? |
| Lieu: | Strasbourg (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Profils : deux bourses de thèses à pourvoir. Contexte scientifique : Bioinformatique et Génome. Les candidats concernés, titulaires d'un DEA, peuvent être soit : - des informaticiens intéressés par la biologie, - des biologistes désirant se tourner vers la bioinformatique. Ils doivent dans tous les cas avoir envie de développer leurs connaissances à l'interface entre l'informatique et la biologie. Les candidats pourront en conséquence avoir une formation de physicien, de chimiste, d'informaticien ou de biologiste. Ils travailleront dans un environnement spécialisé dans les domaines proposés et bénéficieront d'un important soutien scientifique et technique. Deux projets sont proposés : - Le premier projet porte sur l'étude des gènes codant pour des ARNs. De nombreux ARNs non codant restent à découvrir. Les ARNs fonctionnels échappent encore à la grande majorité des techniques de criblage, aussi bien théoriques qu'expérimentales. Un des objectifs de ce projet sera donc de créer, de tester et de promouvoir des outils de détection, de représentation et de calcul d'ARNs non-codant dans les séquences disponibles et les génomes séquencés. - Le deuxième projet porte sur l'analyse de famille de protéines à très forts potentiels thérapeutiques tels les récepteurs nucléaires ou les récepteurs couplés aux protéines G. Un appel important sera fait, dans le cadre du travail proposé, aux outils informatiques de modélisation moléculaire et de génomique prédictive. Dans ce contexte le candidat sera appelé à utiliser les outils de la bioinformatique disponibles mais aussi et surtout à faire progresser les méthodes et/ou les logiciels. |
| Contacts: | Trois laboratoires sont susceptibles d'acceuillir ces candidats : - UPR 9002 CNRS. Direction : Pr. Ehresmann Bernard "LABORATOIRE DE STRUCTURE DES MACROMOLECULES BIOLOGIQUES ET MECANISMES DE RECONNAISSANCE". Equipe Modélisation et simulation d'acides nucléiques. Responsable : Pr. Eric Westhof. Tel : 03 88 41 70 46 email:E.Westhof@ibmc.u-strasbg.fr - UPR 9004 CNRS. Direction : Dr. Dino Moras "LABORATOIRE DE BIOLOGIE ET GENOMIQUE STRUCTURALES". Responsable : Dr. Dino Moras. Tel: 03 88 65 32 20 email:moras@igbmc.u-strasbg.fr - IFR 85, FR CNRS 2059 : "Biomolécules et Innovations thérapeutiques" UMR CNRS "Pharmacologie et physico-chimie des interactions cellulaires et moléculaires". Direction : Pr. Jacques Haiech. Tel :03 88 67 68 89 email:haiech@pharma.u-strasbg.fr Responsables :Pr. Marcel Hibert et Dr. Didier Rognan Tel: 03 88 67 68 18 email:mhibert@pharma.u-strasbg.fr Pr. Jean Cavarelli, I.G.B.M.C., Parc d'Innovation, 1 rue Laurent Fries, BP163, 67404 Illkirch Cedex, France Phone: (33) (0)3 88 65 32 56 Fax: (33) (0)3 88 65 32 76 |
| 01/07/2000 | [MM] | Bioinformatique du médicament : criblage virtuel de chimiothèques |
| Source: | transmis par Philippe Marc |
| Date de parution: | 25/08/2000 | Date limite de réponse: | 05/09/2000 |
| Lieu: | Zurich (Suisse) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Bioinformatique du médicament : criblage virtuel de chimiothèques Allocations ouvertes à la mobilité par l'Ecole Doctorale "Sciences de la Vie et de la Santé" (Strasbourg) Directeur de thèse: Dr Didier Rognan (ex-ETH Zürich) Laboratoire-Equipe d'accueil: UMR CNRS-ULP 7081, Directeur Marcel Hibert Résumé du projet de recherche: Ce travail de thèse se déroulera en deux parties distinctes, la première (12 mois) vise a automatiser une procédure de docking par consensus, la seconde (24 mois) consistant a implémenter six nouvelles fonctions d'évaluation dans trois logiciels de docking. a) Docking par consensus. - Ecriture d'une interface graphique (HTML ou Tcl/Tk) pour générer les fichier entrée/sortie. - Analyse des 30 meilleures poses trouvées par chaque outil (Dock, FlexX, Gold) et clustering des poses par famille (écart quadratique moyen des coordonnées cartésiennes des atomes lourds) - Détermination d'un représentant par famille (meilleure énergie d'interaction) - Etablissement d'une liste propre à chaque outil de docking (classification par énergie d'interaction) - Détermination de la "meilleure" famille commune aux trois logiciels. - Comparaison de la pose commune proposée à la pose cristallographique. Cette procédure devra être automatisée et appliquée à un certain nombre de complexes proteine-ligand pour lesquels aucun des trois outils de docking, utilisé séparément, ne propose la pose cristallographique en tête de liste. b) Evaluation des interactions proteine-ligand par consensus. Le logiciel Dock4.0 pour lequel nous disposons du code source sera modifié de façon implémenter six fonctions d'évaluation additionnelles (Chemscore, FlexX, Gold, Fresno, Pmf, Score). La décomposition de l'énergie d'interaction propre à chaque fonction a déjà été publiée et peut donc être reproduite. La modification du code source de la version 4.0 de DOCK se fera en deux étapes: - implémentation des six fonctions d'évaluation et des paramètres correspondant (en langage fortran et C) - validation des scores proposés par comparaison avec les scores originaux déjà publiés. Une implémentation identique dans les programmes FlexX et Gold sera prévue ultérieurement en fonction des résultats obtenus avec la version modifiée de Dock. Infrastructure Le laboratoire de Pharmacochimie Moléculaire (UMR CNRS/ULP 7083) met a disposition un réseau de 5 stations de travail Silicon Graphics O2 articulé autour d'un serveur de type Origin 200 bi-processeur. L'ensemble des programmes de criblage virtuel et de docking automatique (AutoDock, Dock, FlexX, Gold) ainsi que de graphique moléculaire (Sybyl) nécessaire à la réalisation de ce travail est également disponible. |
| Contacts: | Prof. Marcel Hibert Téléphone : 03 88 67 37 22 / 03 88 67 68 81 Télécopie : 03 88 67 47 94 E-mail : marcel.hibert@pharma.u-strasbg.fr Dr. Didier Rognan Department of Applied BioSciences - ETH Winterthurerstr. 190 CH-8057 Zürich tel:+41.1.635 60 36 fax:+41.1.635 68 84 E-mail: didier@pharma.ethz.ch Les candidats potentiels doivent contacter au plus vite Didier Rognan ou Marcel Hibert. Le dossier devra comprendre: -le CV du candidat -ses résultats au DEA et le palmarès complet du DEA -des lettres de recommandation de son responsable de stage et du responsable du DEA Les dossiers sont à adresser au Professeur Marcel Hibert, Il pourra également vous fournir plus de détails sur le profil souhaité. Les dossiers sont à envoyer au plus vite, et en tout état de cause avant le 5 septembre |
| 01/07/2000 | [MM] | bourse de thèse a été attribuée à Nancy pour une recherche commune à un laboratoire d'informatique (LORIA) et de biologie moléculaire dans le domaine des ARN |
| Source: | posté sur la liste bioinfo du CRIHAN |
| Date de parution: | 28/09/2000 | Date limite de réponse: | ? |
| Lieu: | Vandoeuvre-les-Nancy (France) | Statut: | Thèse | Secteur: | public |
| Description de l'annonce: |
| Une bourse de thèse a été attribuée à Nancy pour une recherche commune à un laboratoire d'informatique (LORIA) et de biologie moléculaire (UMR 7567) dans le domaine des ARN: détermination de structure secondaire en relation avec l'épissage des introns des ARN pré-messagers. Un candidat, soit un informaticien avec une double-compétence en biologie, soit un biologiste voulant se former en informatique, est recherché à partir du 1 octobre 2000. |
| Contacts: | Les personnes intéressées sont priées de prendre contact avec: Alexander BOCKMAYR LORIA (Laboratoire LOrrain de Recherche en Informatique et ses Applications) UMR 7503 CNRS-INRIA-Universités e-mail: Alexander.Bockmayr@loria.fr Téléphone: (33) 03 83 59 30 00 Télécopie: (33) 03 83 27 83 19 Christiane BRANLANT Maturation des ARN et Enzymologie Moléculaire (MAEM) UMR 7567 CNRS-UHP, e-mail: Christiane.Branlant@maem.uhp-nancy.fr Faculté des Sciences, B.P. 239 54506 Vandoeuvre-les-Nancy France |
| 01/07/2000 | [MM] | Software Developers à Gentech (Sophia antipolis) |
| Source: | Ph. Marc (AGM2) |
| Date de parution: | 21/07/2000 | Date limite de réponse: | ? |
| Lieu: | Sophia Antipolis (France) | Statut: | CDI | Secteur: | prive |
| Description de l'annonce: |
| Software Developers à Gentech (Sophia antipolis) Gentech is a biotechnology research laboratory and bioinformatics company. We are developing a cross-platform bioinformatics software package for DNA and protein sequence analysis and visualisation. Three software developer positions are available with the following requirements: - C++ programming - Expertise in one or more of the following platforms:Windows98-NT, Linux and MacOS - Knowledge of 3D programming, (Quickdraw, OpenGL). Gentech is located in the scientific park "Sophia Antipolis" in the South of France near Nice and Cannes, see our web site www.gentech.fr. |
| Contacts: | contact: Gentech 55, Allée Charles Victor Naudin Sophia Antipolis 06410 Biot France Tel : 04 93 95 68 28 Fax : 04 93 95 68 27 |