ASSOCIATION AGM2
Association des Étudiants du DEA d'Analyse de Génome et de Modélisation moléculaire
Offres d'emploi post DEA

Les offres Post-DEA de l'association


40 annonces en cours de validité en Modélisation Moléculaire [MM].Retour aux annonces

DateStatutP/PTitrePays
27/06/2007Stage prive amour france
06/11/2003CDI public Computational Chemist Etats-Unis
05/11/2003CDI prive Molecular Modeler Etats-Unis
09/09/2003CDI prive BIOMEDICAL INFORMATICS - Research Scientist Etats-Unis
03/08/2003Postdoc public Postdoctoral Fellowship Etats-Unis
13/06/2003Thèse public These en modelisation quantique moleculaire a l'Ecole France
11/06/2003Postdoc public POSTDOCTORAL POSITION in COMP.CHEM./COMP. BIOPHYSICS Etats-Unis
10/06/2003Postdoc public Postdoctorals Fellowships in Structural Molecular Biology at the EMBL Outstation France
10/06/2003Thèse public Rôle de la protéine SGT1 dans le cycle cellulaire, une approche France
10/06/2003Thèse public Etude structure-fonction et modélisation moléculaire des transporteurs ABC de type MRP France
10/06/2003Thèse public Simulation Numérique du Comportement Intracellulaire France
10/06/2003CDI prive Computational Chemists/C++ Etats-Unis
24/04/2003Postdoc public Post-Doctorat au CEA Saclay France
08/04/2003CDI prive Computational Chemists Etats-Unis
07/04/2003CDI public SOFTWARE ENGINEER / SCIENTIFIC PROGRAMMER IN PROTEIN CRYSTALLOGRAPHY Allemagne
07/04/2003CDI public SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY Allemagne
07/04/2003Postdoc public POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY Allemagne
07/04/2003Postdoc public Post-doctoral Postion in Structural Genomics Etats-Unis
06/04/2003Postdoc public Post-doctorants CDD 18 moisINRA France
10/02/2003Postdoc public PhD Position, Computational Molecular Biology Canada/Quebec
29/01/2003Postdoc public Postdoc in COMPUTATIONAL MEDICINAL CHEMISTRY Grande-Bretagne
29/01/2003CDI prive Mathematicien - Modelisation dynamique en biologie France
28/10/2002Thèse public Database Mining en Olfaction France
11/09/2002Postdoc public Computational Biology or Bioinformatics Japon
10/09/2002Postdoc public Post-doctoral Computer Programmers in Structural Bioinformatics Grande-Bretagne
03/09/2002CDD prive Chimie-informatique/lead informatics/CRP-VITRY France
30/08/2002Thèse public Thèse en Modélisation Moléculaire Grande-Bretagne
07/08/2002Postdoc public PostDoc position in Bioinformatics Massachussets
07/08/2002Postdoc public Postdoctoral Fellow Japon
07/08/2002CDI prive Modélisateur moléculaire chez L'Oréal France
06/08/2002Thèse public Bourse de thèse fléchée Inter///Bio France
06/08/2002Thèse public Biology PhD Student in Bioinformatics Laboratory Massachussets, USA
24/07/2002Thèse public PhD in Bioinformatics/Computational Biochemistry Grande-Bretagne
22/07/2002Thèse public These en chem-informatique / bio-informatique France
18/07/2002Postdoc public Enzyme Function And Reaction Mechanisms: Computational Studies Ohio, USA
17/07/2002Postdoc public Enhancing Molecular Docking Through High-Performance Computing and Advanced Visualization France
03/07/2001ATER public ATER Physico-Chimie moléculaire et cellulaire au Muséum National d'Histoire Naturelle France
01/07/2001Postdoc prive ABG-6416 - Position postdoctorale en Modelisation Moleculaire France
01/07/2001CDI prive Researcher – Protein structure modelling NAUTILUS BIOTECH France
01/07/2000CDI prive Software Developers à Gentech (Sophia antipolis) France


27/06/2007[MM]amour
Source:officiel
Date de parution:27/06/2007Date limite de réponse:15/09/2007
Lieu:rennes (france)Statut:StageSecteur:prive
Description de l'annonce:
chereche personne pouvons m'apprendre à faire l'amour
Contacts:bystere@yahoo.fr

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06/11/2003[MM]Computational Chemist
Source:http://bioinformatics.org/forums/forum.php?forum_id=2218
Date de parution:06/11/2003Date limite de réponse:?
Lieu:New York State (Etats-Unis)Statut:CDISecteur:public
Description de l'annonce:
A client of ours is seeking a Sr Computational Chemist.

QUALIFICATIONS:
The candidate should be willing to provide molecular modeling support for discovery projects by applying state-of-the-art computational techniques, with the goal of identifying and optimizing novel drug leads.

3 or more years industrial experience in de-novo ligand design,
pharmacophore analyses, ligand docking, library design and analysis, homology modeling and protein-ligand simulations is REQUIRED.

Additional requirements include a Ph.D. in Chemistry, Biochemistry, Biophysics, or a related discipline, and excellent communication skills.
Contacts:HOW TO APPLY:
If you are interested in pursuing this opportunity, please forward your CV, salary requirement, relocation considerations and references to resumes@workwondersstaffing.net. It is important to use the position title as the subject of your email to allow your resume to reach the appropriate recruiter as quickly as possible. If you feel you are not qualified or are not interested in the opportunity, do you know anyone who
might be a good fit?

[Please reference Bioinformatics.Org when responding to this announcement.]

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05/11/2003[MM]Molecular Modeler
Source:Bioinformatiocs.Org
Date de parution:05/11/2003Date limite de réponse:?
Lieu:New York (Etats-Unis)Statut:CDISecteur:prive
Description de l'annonce:
I am assisting to recruit Molecular Modeler for a client's Drug Discovery Applications Group in New York City. Here is more information:

This client is a technology leader specializing in computational methods for drug discovery and development. Benefits include medical, dental, 401(k), flexible spending account, 3+ weeks vacation, stock options, and tuition reimbursement. Visa sponsorship and/or relocation are available.

The successful candidate will become part of a multidisciplinary drug discovery team working on both in-house efforts to improve and apply drug discovery methodologies and on collaborative projects with pharmaceutical/biotechnology partners.

JOB DESCRIPTION:
Actively participate in Drug Discovery Applications Group projects
Apply drug discovery software and perform analysis of the results
Effectively communicate results to other members of the Group
Work closely with the Development Team to test and improve Drug Discovery technologies

QUALIFICATIONS:
Ph.D. in computational chemistry, organic chemistry, or biochemistry
Computational experience in at least 1 of the following areas: molecular modeling, structure-based drug design, virtual ligand screening, computationally-driven lead optimization, ligand-based design, or homology modeling
Excellent verbal and written communication skills
Ability to work independently

SKILLS:
Programming skills: Perl script writing, in particular
Experience with chemical databases
Contacts:HOW TO APPLY:
For consideration, please send CV including publications, thesis topic, and advisor to resumes@workwondersstaffing.net

This client is an Equal Opportunity Employer.

[Please reference Bioinformatiocs.Org when replying to this announcement.]

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09/09/2003[MM]BIOMEDICAL INFORMATICS - Research Scientist
Source:BioJobs
Date de parution:09/09/2003Date limite de réponse:?
Lieu: (Etats-Unis)Statut:CDISecteur:prive
Description de l'annonce:
Responsibilities: Join GE's research in molecular imaging as a
Bioinformatics Scientist, working with world-class experts in imaging physics, molecular biology, and medicinal chemistry, developing the next generation of molecular diagnostics. We need experts in bioinformatics analysis of protein pathways and gene expression to develop tools and techniques for discovering molecular imaging targets and apply these techniques to the study of specific diseases. Projects will involve developing platform technologies for integrating many disparate types of
public and proprietary genomic and proteomic data along with analysis methods to elucidate pathways and identify molecular imaging targets.
Collaborate with GE’s luminary academic and commercial scientific
partners both to develop next generation diagnostic products and to publish research results.
Requirements: Candidates need to have either a PhD in bioinformatics or computational biology, or degrees in both biological and computational sciences, with one being at the PhD level.
·Knowledge of molecular disease mechanisms and pathways.
·Knowledge of genomics and analysis of DNA microarray data.
·Mathematical and computer science background.
·Published work in the bioinformatics field.
·Excellent communication skills (verbal, written, presentation).
·Ability to work effectively in teams.
Demonstrated experience in one or more of the following areas would also be highly desirable:
·Experience in building computational models of biological phenomena.
·Experience in statistical analysis of biological data.
·Experience with microarray tools and algorithms, knowledgeable about their limitations and research areas. ·Experience building
bioinformatics databases and software tools.
Desired: ·Experience in pharmaceutical or biotech industry.
·Experience as Principal Investigator on funded research grants.
·Leadership / coordination ability.

We offer a competitive salary, outstanding benefits package and the professional advantages of an environment that supports your development and recognizes your achievements.
Contacts:To apply to this position, please click on this link.
https://www.research.ge.com/eHire
Please enter GECRD/319910/WB2273 in the job reference code field.

An Equal Opportunity Employer.

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03/08/2003[MM]Postdoctoral Fellowship
Source:
Date de parution:04/07/2003Date limite de réponse:?
Lieu: (Etats-Unis)Statut:PostdocSecteur:public
Description de l'annonce:
Postdoctoral Fellowship under the direction of Dr. Ruth Nussinov, in the Laboratory of Experimental and Computation Biology, to conduct research on protein folding and binding. Will involve computational investigation of structural and functional genomics, and the inter-relationship between protein structure and function and probe the coupling between protein folding and function, and protein binding mechanisms. These
studies are currently at the forefront of structural bioinformatics, with direct implications for protein and for drug design. Will work with novel, state-of-the art computational tools toward these goals.

Ph.D. degree and strong background in molecular calculations; extensive knowledge in protein structures and in molecular simulations; a strong background in biophysics, computational chemistry or structural biology required.

SAIC-Frederick, Inc., a subsidiary of SAIC, is the Operations and
Technical Support (OTS) Contractor for the National Cancer Institute at Frederick (NCI-Frederick) a federally funded research and development center. The mission of SAIC-Frederick, Inc. is to provide scientific, technical, management, administrative, and logistical support to National Institutes of Health (NIH) intramural laboratory research and development related to the causes of and cures for cancer and AIDS.
Intramural research is that conducted by Government scientists operating within various units of NIH, principally the National Cancer Institute (NCI), and the largest institute of NIH. We also conduct basic and applied research in cancer and AIDS; operate and manage the Advanced Biomedical Computing Center (ABCC), the world’s only supercomputer devoted exclusively to biomedical research; and conduct large drug and natural product screening programs.
Excellent salary and benefits accompany our positions, including the opportunity to become an employee-owner in the nation’s largest employee owned research and engineering company.

Job Information
Position Type: Post-Doctoral Research Fellowships
Reference (Job ID number): KMB058452
Start Date: ASAP
Duration: Full Time
Status: open
Contacts:SAIC-Frederick, Inc.
Basic Research Program
D. Higdon
higdon@ncifcrf.gov
http://saic.ncifcrf.gov
How To Apply: email CV or apply online at http://saic.ncifcrf.gov;
or www.saic.com

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13/06/2003[MM]These en modelisation quantique moleculaire a l'Ecole
Source:ABGt-2938
Date de parution:10/06/2003Date limite de réponse:06/07/2003
Lieu:Paris (France)Statut:ThèseSecteur:public
Description de l'annonce:
Date de debut de diffusion du poste : 10/06/2003
Date de fin de diffusion prevue : 06/07/2003

Modelisation microscopique et optimisation des proprietes de molecules d’interet pharmaceutique :
complementarite avec des etudes experimentales

Plusieurs molecules d’interet pharmaceutique, ayant une action
anti-tumorale reconnue, ont fait l’objet d’etudes structurales poussees. Par exemple le busulfan a ete etudie au laboratoire SPMS, sous la responsabilite de N. Ghermani. Cette molecule, et d’autres, ont pu etre cristallisees, et etudiees par diffraction X haute resolution : ceci a permis une analyse detaillee de la densite electronique(1).
La comprehension du comportement alkylant d’une telle molecule au niveau de l’ADN ou des cellules necessite une analyse theorique poussee.
Cette molecule est par ailleurs tres active, et des etudes sont en cours pour en empecher la cristallisation en milieu biologique, cause reconnue de deces. Il s’agit essentiellement d’encapsuler des molecules, tout en maintenant la reconnaissance des sites d’action bio-chimique.
En dehors du travail primordial de pharmaco-technie, il apparait
important de comprendre par voie theorique puis de controler par modelisation les mecanismes microscopiques qui sont en jeu. Cet objectif est commun a de nombreuses molecules vectorisees par des nano-particules pharmacologiques.
Les grandes phases du travail de these seraient les suivantes :
1. Etude theorique de la molecule de busulfan (et aussi d’autres
molecules presentant la meme problematique de forte cristallisation) et comparaison avec les
resultats experimentaux .
Modelisation de l’interaction molecule-ADN.
2. Modelisation des forces de cohesion qui favorisent la
cristallisation. Cette phase fera largement appel a la description d’un solide en termes de « clusters ».
3. Description des interactions dans une molecule en capsulee dans un vecteur ou une nano-particule. Dans cette phase, a la fois l’approche par cluster et la modelisation conformationnelle developpees ces dernieres annees seront importantes.

Ce travail trouvera un prolongement sur des objectifs plus larges :
4. Modelisation des interactions entre nanoparticules.
5 . Modelisation de l’interaction complexe-site actif.

Un tel projet s’inscrit directement dans la ligne des travaux developpes au niveau theorique dans l’UMR ces dernieres annees, ainsi que dans l’operation scientifique « materiaux d’interet pharmaceutique », mixte UFR de Pharmacie / ECP. Il permettrait un pont avec une operation scientifique prioritaire actuelle. Il est certain que l’etude ne peut avancer que par une interaction permanente entre des composantes pharmacotechnique, structurale et theorique.

Le directeur de these serait Jean Michel Gillet, soutenu en co-direction par Nour Eddine Ghermani d’une part (pour les aspects biochimique et structural) et Pierre Becker d’autre part (concernant la reflexion sur les modeles a mettre en œuvre)

A noter enfin qu’une telle collaboration, si elle est un succes, peut deboucher sur des applications a terme mettant en jeu des grands groupes pharmaceutiques.

Jean Michel GILLET, ECP et SPMS
Nour Eddine GHERMANI, Paris XI et SPMS
Pierre BECKER, ECP et SPMS

References :
1. Experimental electron density and electrostatique potential analysis of Zinc (aspirinate)2(H2O)2 complex : a 3d10 metal bonding to a drug ligand A. Spasojevic-de Bire, N. Bouhmaida, A. Kremenovic, G. Morgant, N.E. Ghermani (2002), J. Phys.
Chem. A, 106, 12170-12177

2. A new approach to the electron distribution in flexible molecules. Application to conformational analysis P. Becker, E. Bec, (1996) Chem. Phys. Letters, 260, 319

3. Interpreting Compton anisotropy of ice Ih : a cluster partitioning method S. Ragot, J.M. Gillet, P. Becker, Phys Rev. B, 63, (2002) 235115-1 to 235115-6

4. Electrostatic properties of ibuprofen
N.E. Ghermani, M. Dutheil, P. Becker, J. Chem. Phys. (2002), 117,
205-212

Une bonne formation en physique ou chimie quantique est essentielle.
Une precedente experience dans la modelisation moleculaire serait
appreciable.
Un bon classement de DEA sera un atout favorable, sinon determinant,dans l'obtention d'une bourse de l'Ecole Doctorale de l'Ecole Centrale Paris.
Tous les cours de l'ECP sont accessibles aux doctorants du laboratoire SPMS, avec la possibilite de valider le Diplome d'Etudes Superieures Professionnelles delivre par l'Ecole Centrale Paris.
Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre.
Contacts:Envoyer un CV ainsi qu'une lettre de motivation (sous la forme d'un courrier electronique avec CV en document attache) a gillet@spms.ecp.fr

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11/06/2003[MM]POSTDOCTORAL POSITION in COMP.CHEM./COMP. BIOPHYSICS
Source:BioInfo
Date de parution:11/06/2003Date limite de réponse:?
Lieu:La Jolla (Etats-Unis)Statut:PostdocSecteur:public
Description de l'annonce:
Applications are invited for a postdoctoral position starting September 2003 or later in the Department of Biochemistry & Molecular Biology within the Center for Biological Modeling at Michigan State University (http://biomodel.msu.edu/). The position is available initially for 1 year with the possibility for extension.

Research interests focus on three main areas: Modeling of large
supramolecular assemblies, in particular interactions between mismatched DNA and the mismatch recognition protein mutS; development of hybrid explicit/implicit solvation methods; and development and application of novel methods for protein structure prediction and refinement.

Ideal candidates would have a strong background in computational or theoretical chemistry, biophysics, biochemistry, structural biology or related discplines. Familiarity with computational chemistry methods, experience in molecular modeling and simulation of biological systems, advanced programming skills, knowledge of the UNIX/Linux operating system, and an interest in developing new methodologies are highly desirable.

MSU, located in East Lansing, Michigan, provides a unique and
challenging interdiscplinary research environment at the interface of biological and physical sciences. East Lansing, located between the Great Lakes, offers a pleasant living environment with many cultural events and excellent opportunities for outdoor activities.
Contacts:Interested applicants should send a curriculum vitae, including relevant experiences, a list of publications, and contact information of three references, to the address listed below. Electronic responses are highly encouraged.

Michael Feig
Department of Molecular Biology, TPC-6
The Scripps Research Institute
10550 N Torrey Pines Road
La Jolla, CA 92037
USA
email: meikel@scripps.edu

http://www.scripps.edu/~meikel/msu/feig.html

Comments? Post your replies to
http://bioinformatics.org/forums/forum.php?forum_id=1856

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10/06/2003[MM]Postdoctorals Fellowships in Structural Molecular Biology at the EMBL Outstation
Source:
Date de parution:25/05/2003Date limite de réponse:?
Lieu:Grenoble (France)Statut:PostdocSecteur:public
Description de l'annonce:
The European Molecular Biology Laboratory (EMBL) is an international research organization consisting of a headquarters laboratory situated in Heidelberg Germany and four Outstations. The EMBL Outstation in Grenoble has an active research programme in structural molecular biology and shares a common site with the European Synchrotron Radiation Facility (ESRF) and the Institut Laue Langevin (ILL), world leading centres for X-ray and neutron scattering.
We are seeking to recruit postdoctoral fellows with a strong interest in structural biology who can benefit from the juxtaposition of excellent wet-lab facilities with state-of-the-art beamlines for protein crystallography. Depending on the particular laboratory, candidates should either have a background in molecular biology and biochemistry combined with an interest in structural biology or a background in protein crystallography with some experience in molecular biology and biochemistry.

Fellowships are available in the following laboratories:

Stephen Cusack: Protein/RNA interaction group: the structural basis of protein-RNA recognition in the context of the signal recognition particle and proteins interacting with mRNA or tRNA. e-mail: cusack@embl-grenoble.fr.

Rob Ruigrok: Virus structure group: structure and function of viruses and sub-viral assemblies. e-mail: ruigrok@embl-grenoble.fr.

Christoph Müller: Protein/DNA interaction group: the structural basis of transcriptional regulation, transcription factor/DNA recognition and the mechanism of nuclear transport.
e-mail: mueller@embl-grenoble.fr.

Winfried Weissenhorn: Membrane fusion group: the structural basis for viral and cellular membrane fusion processes. e-mail:
weissen@embl-grenoble.fr.

EMBL is an inclusive, equal opportunity organisation with an exciting and stimulating research environment.

Contacts:Applicants should submit a curriculum vitae, quoting reference no., with concise description of research experience and the names and addresses of at least two referees to:

Head of Outstation,
EMBL
6 rue Jules Horowitz
c/o ILL; B.P. 181;
F - 38042- Grenoble Cedex 9, France;

Fax: 33-4-76-20 77 86.

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10/06/2003[MM]Rôle de la protéine SGT1 dans le cycle cellulaire, une approche
Source:http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-041.html
Date de parution:10/06/2003Date limite de réponse:?
Lieu:Gif sur Yvette (France)Statut:ThèseSecteur:public
Description de l'annonce:
Proposition de sujet de thèse SL-DSV-03-041 DSV
Domaine de recherche
Sciences du vivant/Bio-informatique, simulation bio-moléculaire,
Sciences du vivant/Biologie structurale

1. Intitulé du sujet
Rôle de la protéine SGT1 dans le cycle cellulaire, une approche
bio-informatique et structurale
Topic tittle
SGT1 function in cell cycle regulation probed by biocomputing and
structural biology.

2. Détail du sujet
SGT1 est une protéine très conservée, essentielle à la régulation du cycle cellulaire. Sa fonction exacte demeure inconnue. Prédiction de structure, docking et RMN seront associés pour caractériser comment SGT1 interagit avec ses multiples partenaires biologiques. En étroite collaboration avec des généticiens et des biologistes des plantes, ce travail permettra d'établir le role de la protéine au cours du cycle
cellulaire.

Detailed tittle
SGT1 is an essential component of the cell cycle signalling pathway although its function remains unclear. Structure prediction, docking and NMR will be used to unravel the way SGT1 interacts with its numerous biological partners. In close collaboration with geneticists and plant biologists, this work will shed light on the role of SGT1 in the cell cycle.

3. DEA recommandés
DEA Analyse de génomes et Modélisation Moléculaire. DEA Biophysique Moléculaire.

4. Informations pratiques
Direction des sciences du vivant/Département de Biologie Joliot Curie Service : Service de Biophysique des Fonctions Membranaires

Date souhaitée pour le début de la thèse : 1/09/2003
Contacts:5. Personnes à contacter par le candidat
Raphaël Guerois
LBPM/Laboratoire de Biophysique des Protéines et des Membranes
CEA Saclay. 91191 Gif sur Yvette Cedex
Téléphone : +33 1 69 08 96 79

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10/06/2003[MM]Etude structure-fonction et modélisation moléculaire des transporteurs ABC de type MRP
Source:http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-117.html
Date de parution:10/06/2003Date limite de réponse:?
Lieu:Grenoble (France)Statut:ThèseSecteur:public
Description de l'annonce:
Proposition de sujet de thèse SL-DSV-03-117 DSV

Domaine de recherche
Sciences du vivant/Bio-informatique, simulation bio-moléculaire

1. Intitulé du sujet
Etude structure-fonction et modélisation moléculaire des transporteurs ABC de type MRP

Topic tittle
Structure-function and molecular modelling of MRP-type ABC transporters

2. Détail du sujet
Sur la base des données structurales parcellaires obtenues récemment par microscopie et cristallographie, il s'agira d'élaborer des modèles des transporteurs ABC homologues SUR, YCF1, MRP1 en utilisant les contraintes imposées par nos résultats. Ces modèles permettront d'une part de mieux interpréter les résultats connus et d'autre part de formuler des hypothèses sur les mécanismes et de concevoir des expériences pour les tester. Ce projet demandera des compétences en bioinformatique ainsi qu'en biologie et sera réalisé en parallèle dans l'équipe de simulation et modélisation moléculaire et de l'équipe Transporteurs ABC du laboratoire.

Detailed tittle
On the basis of existing structural data obtained by microscopy and crystallography, models of the homologous ABC transporters, SUR, YCF1 and MRP1 will be constructed using constraints imposed by our experimental results. These models will allow a better interpretation of known data and will constitute a basis for bringing forth hypothesis on the mechanisms and for designing experiments to test these hypothesis.
This project will require knowledge of bioinformatics as well as biology and will be pursued in parallel in the Molecular Simulation and
Modelisation group and the ABC transporters group of the laboratory.

3. DEA recommandés
Modélisation, Mathématiques, Bioinformatique, Biologie Structurale et Fonctionnelle

4. Informations pratiques
Direction des sciences du vivant/Département Réponse et Dynamique
Cellulaires

Date souhaitée pour le début de la thèse : Oct/nov 2003
Contacts:5. Personnes à contacter par le candidat
Serge CROUZY
BMC/Laboratoire de Biophysique Moléculaire et Cellulaire
CEA-DRDC-BMC, 17 rue des Martyrs, 38054 Grenoble
Téléphone : +33 4 38 78 48 48

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10/06/2003[MM]Simulation Numérique du Comportement Intracellulaire
Source:http://www-dsv.cea.fr/thema/SujDSV/SL-DSV-03-104.html
Date de parution:10/06/2003Date limite de réponse:?
Lieu:Grenoble (France)Statut:ThèseSecteur:public
Description de l'annonce:
Proposition de sujet de thèse SL-DSV-03-104 DSV
Domaine de recherche
Sciences du vivant/Bio-informatique, simulation bio-moléculaire

1. Intitulé du sujet
Simulation Numérique du Comportement Intracellulaire
Topic tittle
Numerical Simulation of Intracellular Behavior

2. Détail du sujet
Récemment, il y a une révolution dans la biologie due aux projets
génomiques. Le déluge des données produites par ces projets a changé la façon de penser la recherche en biologie et permet des approches novatrices pour aborder les problèmes biologiques. Le projet proposé pour cette thèse se situe dans le domaine de la biologie post-génomique et a pour but ultime la compréhension des réseaux de protéines - comment ils se comportent et les règles générales qui les gouvernent
Detailed tittle
Recently, there has been a revolution in biology due to the genome projects. The deluge of data produced by these projects has changed the way in which research is done in biology and has led to new approaches to the treatment of biological problems. The project proposed for this thesis falls in the area of post-genomic biology and has as its aim the understanding of protein networks - how they behave and the rules that govern them.

3. DEA recommandés
DEAs de Modélisation, de Physique, de Chimie, de Biologie Structurale ou de Biologie Moléculaire

4. Informations pratiques
Direction des sciences du vivant/Institut de Biologie Structurale

Date souhaitée pour le début de la thèse : octobre 2003
Contacts:5. Personnes à contacter par le candidat
Martin Field
LDM/Laboratoire de Dynamique Moléculaire
IBS 41 rue J. Horowitz 38027 Grenoble
Téléphone : +33 4-38-78-95-94

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10/06/2003[MM]Computational Chemists/C++
Source:Bioinformatics.Org
Date de parution:10/06/2003Date limite de réponse:?
Lieu:New York (Etats-Unis)Statut:CDISecteur:prive
Description de l'annonce:
Salary plus bonus to 150K+

Extraordinarily gifted computational chemists at all levels of
experience sought to join a select research group within a rapidly growing New York-based technology firm known for scientific leadership in the development of computational chemistry software for the pharmaceutical and biotechnology industries. We are looking for individuals with an exceptionally distinguished history of academic and/or industrial accomplishment to join our efforts to fundamentally transform the process of drug discovery.Candidates should have world-class credentials in computational chemistry, biology, or physics,
or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills.
Relevant areas of experience might include the computation of
protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecular systems, free energy perturbation methods, and methods for speeding up evaluation of
electrostatic energies -- but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of activity for the firm include structure- and ligand-based drug design, protein structure determination through homology modeling, molecular mechanics force field development, de novo drug design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations.We are eager to add both senior- and junior-level members to our world-class team (including at least one group head with
management responsibilities), and are prepared to offer above-market compensation to candidates of truly exceptional ability.
Contacts:If you are interested send a Word Attachment copy of your resume to the attention of Norm Davis at normd@cisny.com

[Please Mention Bioinformatics.Org when replying to this announcement.]

Comments? Post your replies to
http://bioinformatics.org/forums/forum.php?forum_id=1835

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24/04/2003[MM]Post-Doctorat au CEA Saclay
Source:BioInfo
Date de parution:24/04/2003Date limite de réponse:15/12/2003
Lieu:Saclay (France)Statut:PostdocSecteur:public
Description de l'annonce:
Titre: Post-Doctorat au CEA Saclay: Simulation moléculaire du transporteurABC bactérien MsbA inséré dans une membrane en vue de modéliser l'action de la Pgp

Présentation du laboratoire:
Le stage se déroulera au Service de Biophysique des Fonctions Membranaires (DBJC / DSV), dans le cadre d'une collaboration entre le Laboratoire de Biophysique des Protéines et des Membranes et le Laboratoire de Transport Membranaire et Détoxication, au Centre d'Etudes de Saclay (91).

Description de la mission proposée:
La P-glycoprotéine (P-gp) est un transporteur membranaire actif de détoxication cellulaire appartenant à la grande famille ABC ("ATP Binding Cassette"). Remarquablement multispécifique, la P-gp transporte de nombreux xénobiotiques amphiphiles, et nous venons de montrer qu'elle transporte un lipide membranaire, le cholestérol, vers le feuillet externe de la membrane. La protéine MsbA, transporteur ABC bactérien homodimérique, est très proche de la P-gp en terme d'homologie de séquences. C'est aussi un bon homologue fonctionnel de la P-gp puisqu'elle transporte un lipide létal pour la bactérie.
Une structure à haute résolution de MsbA vient d'être publiée. La forme très particulière, "en V" fortement ouvert, du dimère de MsbA est atypique pour une protéine membranaire, et pose le problème de la distribution des lipides autour de la protéine. Déterminer cette distribution permettrait d'avancer vers la compréhension des mécanismes de transport de la MsbA, mais aussi de la P-gp. Seule la simulation moléculaire est actuellement en mesure de fournir une telle information. Nous nous proposons donc d'obtenirpar simulation moléculaire un modèle du système MsbA-membrane, permettant en premier lieu de décrire l'interfacep rotéine-lipide, puis de localiser le site de liaison de son substrat physiologique. L'objectif est de proposer un mécanisme de transport pour ces transporteurs ABC. Ce travail sera effectué en collaboration avec notre équipe de simulation moléculaire.

Formation et profil requis:
Solide bagage en simulation moléculaire des protéines, avec utilisation des programmes CHARMM (de préférence), ou AMBER, ou GROMACS; bonne connaissance des protéines (plus particulièrement celles associées aux systèmes membranaires) permettant ultérieurement d'aborder la problématique de la modélisation par homologie.

Informations générales:
Le poste est à pourvoir dès maintenant et avant le 15/12/03. Le contrat proposé est un CDD de 1 an renouvelable une fois.

Lieu de travail: Centre d'Etudes de Saclay (RER Le Guichet, près d'Orsay).
Contacts:Procédure de dépôt de candidature:
Envoyer par e-mail à Stéphane Orlowski (orlowski@dsvidf.cea.fr) un CV détaillé et une lettre de motivation.

Stéphane Orlowski, SBFM / DBJC, Centre d'Etudes de Saclay, 91191
Gif-sur-Yvette cedex.

Tel: 01 69 08 95 77; FAX: 01 69 08 81 39.


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08/04/2003[MM]Computational Chemists
Source:
Date de parution:08/04/2003Date limite de réponse:?
Lieu:New York (Etats-Unis)Statut:CDISecteur:prive
Description de l'annonce:
Extraordinarily gifted computational chemists at all levels of experience sought to join a select research group within a rapidly growing New York-based technology firm known for scientific leadership in the development of computational chemistry software for the pharmaceutical and biotechnology industries. We are looking for individuals with an exceptionally distinguished history of academic and/or industrial accomplishment to join our efforts to fundamentally transform the process of drug discovery.Candidates should have world-class credentials in computational chemistry, biology, or physics, or in a relevant area of computer science or applied mathematics, and must have unusually strong research and software engineering skills. Relevant areas of experience might include the computation of protein-ligand binding free energies, molecular dynamics and/or Monte Carlo simulations of biomolecular systems, application of statistical mechanics to biomolecu lar systems, free energy perturbation methods, and methods for speeding up evaluation of electrostatic energies -- but specific knowledge of any of these areas is less critical than exceptional intellectual ability and a demonstrated track record of achievement. Current areas of activity for the firm include structure- and ligand-based drug design, protein structure determination through homology modeling, molecular mechanics force field development, de novo drug design algorithms, and the development of special-purpose hardware to accelerate computational chemistry simulations.We are eager to add both senior- and junior-level members to our world-class team (including at least one group head with management responsibilities), and are prepared to offer above-market compensation to candidates of truly exceptional ability.
Contacts:Please send your resume (including list of publications, thesis topic, and advisor, if applicable), along with a history of academic performance (including GPAs as well as SAT, GRE, and other standardized test scores), to . SALARY $ 100,000- 150,000 depending on experience there is flexibility.
SUBMIT RESUMES TO:
Concepts in Staffing
ATT: Norm Davis
normd@cisny.com

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07/04/2003[MM]SOFTWARE ENGINEER / SCIENTIFIC PROGRAMMER IN PROTEIN CRYSTALLOGRAPHY
Source:
Date de parution:07/04/2003Date limite de réponse:15/05/2003
Lieu:Heidelberg (Allemagne)Statut:CDISecteur:public
Description de l'annonce:
EMBL/V/03/22
rev. April 2003

Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg: SOFTWARE ENGINEER / SCIENTIFIC PROGRAMMER IN PROTEIN CRYSTALLOGRAPHY
Grade: 5 or 6, depending on age, experience and qualifications Duty Station: Hamburg, Germany

Commencing Date: As soon as possible after closing date
Job Description: The work will involve development of graphical user interfaces (to be built on the existing modules), support of the Web and Email server, support of remote execution of ARP/wARP jobs on local mulit-processor computer cluster.

Qualifications and Experience: Applicants should have a computational background and experience in the design of GUI. Profound knowledge of C/C++, Java/Javascript, Perl, Tcl/Tk, HTML or Python programming environments is required. Some familiarity with crystallography will be of advantage.

Contract: A contract of 1 year will be offered to the successful candidate. This may be renewed, depending on circumstances at the time of the review.

Closing date: 15.05.03
EMBL Web site: http://www.embl.de/ and http://www.embl-hamburg.de

Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.
Contacts:To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/22, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany.
Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de

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07/04/2003[MM]SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY
Source:
Date de parution:07/04/2003Date limite de réponse:15/05/2003
Lieu:Heidelberg (Allemagne)Statut:CDISecteur:public
Description de l'annonce:
EMBL/V/03/21
rev. April 2003

Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg:

SCIENTIFIC PROGRAMMER & ALGORITHM DEVELOPER IN PROTEIN CRYSTALLOGRAPHY
Grade: 5 or 6, depending on age, experience and qualifications Duty Station: Hamburg, Germany Commencing Date: As soon as possible after closing date Job Description: The work will involve research, development and/or coding the software modules in the areas of information theory, estimation theory, statistical pattern recognition, neural networks for information reduction and computer learning, independent component analysis - all applied for 3-dimensional image interpretation. The emphasis is on computational techniques.

Qualifications and Experience: Programming experience and familiarity with some of the above-mentioned areas are essential.

Contract: A contract of 1 year will be offered to the successful candidate. This may be renewed, depending on circumstances at the time of the review.

Closing date: 15.05.03

EMBL Web site: http://www.embl.de/ and http://www.embl-hamburg.de
Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.
Contacts:To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/21, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany.
Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de

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07/04/2003[MM]POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY
Source:
Date de parution:07/04/2003Date limite de réponse:?
Lieu:Heidelberg (Allemagne)Statut:PostdocSecteur:public
Description de l'annonce:
EMBL/V/03/PD/05
rev. April 2003

Member States of EMBL (Austria, Belgium, Denmark, Finland, France, Germany, Greece, Israel, Italy, the Netherlands, Norway, Portugal, Spain, Sweden, Switzerland and the United Kingdom) are advised that applications are being sought for the following position in Hamburg:

POSTDOCTORAL POSITION in PROTEIN CRYSTALLOGRAPHY

Applications are invited for a postdoctoral fellow position at the EMBL Outstation in Hamburg, Germany. The work will involve development of tools and protocols for assembling, tuning and running software modules, specifically for structure solution, improvement of crystallographic phases, automatic interpretation of electron density maps and assessment of quality of X-ray data and structural models. A background in protein crystallography and interest in methodology is essential. Emphasis will be on computational techniques. Familiarity with computer programming, statistics and mathematical algorithms is advantageous. Please note that EMBL does not return CVs and attached documents to applicants. EMBL is an inclusive, equal opportunity employer offering attractive conditions and benefits appropriate to an international research organisation.
Contacts:To apply for this position, candidates should submit a detailed CV, including a list of publications (if relevant), and a summary of recent projects, scientific interests and expertise, as well as the names and addresses of two referees for letters of recommendation, quoting ref. no. 03/PD/05, to: The Personnel Section, EMBL, Postfach 10.2209, 69012 Heidelberg, Germany.
Fax: +49 6221 387555 email: jobs@EMBL-Heidelberg.de

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07/04/2003[MM]Post-doctoral Postion in Structural Genomics
Source:
Date de parution:07/04/2003Date limite de réponse:?
Lieu:Yale (Etats-Unis)Statut:PostdocSecteur:public
Description de l'annonce:
Applicants are invited for a post-doctoral post in the Department of Molecular Biophysics and Biochemistry at Yale University. The position is for two years with possible extensions. Choice of project would to some degree depend on the applicant's interests and abilities, though it is expected that the research will be purely computational and will fall into the emerging field of structural genomics: classifying protein fold families in genomes, developing sequence and structure comparison techniques, and developing databases and analyses for the new genomic information. The ideal applicant would have a PhD (preferably in bioinformatics, biophysics, genetics, or computer science) and have already had some experience in one of the above-mentioned research areas. He or she would be very skilled in programming and using the computer to solve problems (e.g. experience with C/C++, perl5, SQL, HTML/java, fortran, blast/fasta, excel/word, Irix/linux, and so on).
Contacts:Please contact Mark Gerstein for further information (MB&B Department, PO Box 208114, Bass Center, Yale University, New Haven, CT 06520, FAX 203 432 5175, Mark.Gerstein@Yale.edu).

Applicants are requested to send a CV that includes a list of publications and details of 3 references. Normal e-mail is OK for all correspondence. However, copies of official documents should follow by regular post. Further details about the position and structural genomics research at Yale can be obtained over the web at: http://bioinfo.mbb.yale.edu/genome.

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06/04/2003[MM]Post-doctorants CDD 18 moisINRA
Source:BioInfo
Date de parution:06/04/2003Date limite de réponse:15/04/2003
Lieu:Jouy-en-Josas (France)Statut:PostdocSecteur:public
Description de l'annonce:
L'INRA recrute 40 post-doctorants sur des contrats à durée déterminée (18 mois) (voir le site http://www.inra.fr/drh rubrique "L'INRA recrute 40 post-doctorants").

Il n'y a aucune condition de nationalité. Les dossiers sont à rendre pour le 15 avril.

Notre unité, en collaboration avec l'unité Neurobiologie de l'Olfaction et de la Prise Alimentaire (NOPA) (également située sur le centre de recherche de Jouy-en-Josas) propose un sujet de post-doctorat ayant trait à la modélisation moléculaire de récepteurs olfactifs (qui sont des récepteurs à 7 segments transmembranaires couplés aux protéines G). Brièvement, il s'agit de modéliser certains récepteurs olfactifs d'intérêt pour l'unité NOPA et de tester la fixation de familles d'odorants sur ces récepteurs par des techniques d'amarrage moléculaire (docking). Les ligands potentiels seront ensuite testés expérimentalement.
Contacts:Pour plus d'information, les personnes intéressées sont priées de me contacter, le plus tôt possible, à l'adresse indiquée ci-dessous.

Jean-Francois Gibrat Tel: +33 (1) 34 65 28 97
Mathematique Informatique et Genome, Fax: +33 (1) 34 65 29 01
Institut National de la Recherche Email: gibrat@jouy.inra.fr
Agronomique, Domaine de Vilvert,
Jouy-en-Josas 78352 cedex, France

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10/02/2003[MM]PhD Position, Computational Molecular Biology
Source:http://www.cnd.mcgill.ca/~swain
Date de parution:10/02/2003Date limite de réponse:01/09/2003
Lieu:Montreal (Canada/Quebec)Statut:PostdocSecteur:public
Description de l'annonce:
PhD POSITIONS IN COMPUTATIONAL BIOLOGY
Centre for Non-Linear Dynamics, McGill University, Montreal. http://www.cnd.mcgill.ca

Applications are invited for one or two PhD positions in the area of computational molecular biology at McGill University. This is an exciting, rapidly growing field driven by the recent explosion in quantitative biological data. See Nature 397, 89 (1999). Students will investigate the `design' behind biochemical information processing networks in simple living organisms. We use techniques from stochastic systems, non-linear dynamics, statistical mechanics and Bayesian probability theory. The positions are ideal for students, who have or expect to obtain a good degree in Mathematics or Physics, and are committed to moving into the areas of molecular biology and bioinformatics.

The Centre for Non-Linear Dynamics is based around a group of mainly theorists in the department of Physiology. It offers a unique graduate training and is an ideal environment for gaining both modelling and biological expertise.

More details are at http://www.cnd.mcgill.ca/~swain
Contacts:Please send/email a CV with the names of two referees to Peter Swain, Department of Physiology, McGill University, 3655 Promenade Sir William Osler, Montreal, Quebec, Canada H3G 1Y6. A probable start date is around September 2003.

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29/01/2003[MM]Postdoc in COMPUTATIONAL MEDICINAL CHEMISTRY
Source:bioinformatics.org
Date de parution:29/01/2003Date limite de réponse:?
Lieu:Salford (Grande-Bretagne)Statut:PostdocSecteur:public
Description de l'annonce:
Applications are invited for a BBSRC-funded post-doctoral position
available immediately to work with Dr Sylvie Ducki on a project
entitled the Design, Synthesis and Biological Evaluation of Novel
Tubulin Ligands.

The aim of the project will be to establish a molecular model for the
interactions in tubulin-ligand complexes using molecular modelling and
docking tools.

Candidates should have a postgraduate degree in a molecular modelling
related subject or experience in medicinal chemistry together with a
proven aptitude for computational work. The position will involve
close co-operation with synthetic chemists as well as biochemists
therefore applicants should enjoy teamwork and show an active interest
in related scientific disciplines.

The salary will be on the RA1A scale (£17,626-£26,491) depending on
age and experience. The post is available immediately and will be for
two years.
Contacts: Interested applicants should submit (for a quick contact use e-mail) a
cover letter and a CV to Dr. Sylvie Ducki, (s.ducki@salford.ac.uk)
Centre for Molecular Drug Design, Cockroft Building, University of
Salford, Salford, M5 4WT, UK.

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29/01/2003[MM]Mathematicien - Modelisation dynamique en biologie
Source:ABG-7555
Date de parution:16/01/2003Date limite de réponse:25/02/2003
Lieu:Paris (France)Statut:CDISecteur:prive
Description de l'annonce:
Helios Biosciences, jeune entreprise de biotechnologies, lelaureate du 4eme concours creation-developpement d'entreprises innovantes du Ministere de la Recherche,selectionne des cibles therapeutiques pour soigner les maladies neurologiques grace a des modeles dynamiques des reseaux d'interactions moleculaires du systeme nerveux.

Le poste concerne le developpement et la mise au point d'un systeme de modelisation de processus biologiques complexes sous la forme de reseaux . Le collaborateur aura pour mission la recherche et la selection l'algorithmes,leur programmation et integration dans le modele, la mise au point et la validation.

Notre futur collaborateur, docteur ou ingenieur, aura une formation de haut niveau en Mathematiques, et si possible des notions en biologie. Pour mener a bien sa mission au sein de la societe, il est indispensable que celui-ci ait une bonne competence en algebre et en statistiques (notamment analyse matricielle, theorie des graphes). L'algorithmique de propagation / retro propagation de signaux dans des reseaux sera maitrisee.
Autres exigences : autonomie en matiere de programmation, anglais lu et parle, dynamisme et capacites d'initiative (contexte start-up de biotechnologies).
Contacts:Priere de nous envoyer votre CV, votre date de disponibilite et votre souhait de remuneration.

Votre contact est :
Olivier SOUPAULT olivier@heliobiosciences.com
06 08 69 24 50

Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre.

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28/10/2002[MM]Database Mining en Olfaction
Source:ABGt-2323
Date de parution:23/10/2002Date limite de réponse:01/12/2002
Lieu:Orléans (France)Statut:ThèseSecteur:public
Description de l'annonce:
ABGt-2323-Database Mining en Olfaction - Universite d'Orleans

Date de debut de diffusion du poste : 23/10/2002
Date de fin de diffusion prevue : 01/12/2002

Une bourse de these est disponible au Laboratoire de Chimiometrie et BioInformatique (CBI) de l'Universite d'Orleans. Cette structure, liee a plusieurs partenaires industriels, travaille sur differentes thematiques concernant la Chimie Medicinale, la biodisponibilite (ADME), la toxicite et l'Olfaction par les methodes de la Modelisation Moleculaire et
Database Mining (DBM).

Le sujet de these propose consiste a travailler dans le domaine de l'olfaction en exploitant plusieurs techniques DBM innovatrices. Le candidat doit posseder des bonnes connaissances en BioChimie. Une experience en Chimie Informatique, modelisation
moleculaire et gestion de bases de donnees constituerait un plus.
Contacts:Les candidats doivent envoyer un CV en format MS Word (avec une photo d'identite jointe), une lettre de motivation et deux references a:

Prof. Jacques R. CHRETIEN
Lab. Chimiometrie et BioInformatique
Universite d'Orleans
B.P.6759
45067 Orleans Cedex 2
Email: jacques.chretien@univ-orleans.fr
http://iris.univ-orleans.fr

et, pour connaissance, a:
Dr. Marco Pintore (Directeur Adjoint)
Email: marco.pintore@univ-orleans.fr

Merci de preciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la reference ABG de cette offre.

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11/09/2002[MM]Computational Biology or Bioinformatics
Source:hd-emploi-info
Date de parution:11/09/2002Date limite de réponse:?
Lieu:Kyoto (Japon)Statut:PostdocSecteur:public
Description de l'annonce:
A Post-Doctoral Position in
Computational Biology or Bioinformatics
in Institute for Chemical Research
Kyoto University, Japan

A post-doctoral position in computational biology or bioinformatics is available at the Proteome Informatics Laboratory, Institute for Chemical Research, Kyoto University, Japan. The laboratory was established in April 2002 with donations from Silicon Graphics Japan,Ltd. The main objective of the laboratory is to build novel computational approaches for analyzing a variety of subjects related to proteomes.

Current application areas of the laboratory include protein-protein interaction, docking between a protein and its ligand, small-molecule similarity, and pathways.

The laboratory uses a variety of computational techniques, including algorithmic/thoretical approaches such as approximation algorithms for combinatorial optimization problems as well as machine learning techniques such as active ensemble methods and probabilistic models like finite-mixture models, hidden Markov models, and stochastic grammars.

The candidate should have a Ph.D. and solid technical experience in one of the above fields or another field in computer science or a similar quantitative area of study. The applicant should be
enthusiastic and energetic in doing new research in proteome
informatics and should have sufficient programming skills in C, C++ or Java.

The laboratory is well funded, and an excellent research environment will be provided. The position is for one year but renewable, by mutual agreement, until as late as March 2005.

Kyoto University's Institute for Chemical Research is located 10 miles south of downtown Kyoto and 25 miles north of the center of Nara, and thus convenient to Japan's two most famous historical cities. The location is ideal for you to both enjoy Japanese traditional beauty and to devote yourself to a new research field, proteome informatics.

Contacts:Please send your detailed curriculum vitae to:

Dr. Hiroshi Mamitsuka
Associate Professor
Institute for Chemical Research
Kyoto University
Email: mami@kuicr.kyoto-u.ac.jp

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10/09/2002[MM]Post-doctoral Computer Programmers in Structural Bioinformatics
Source:http://jobs.ac.uk
Date de parution:10/09/2002Date limite de réponse:03/10/2002
Lieu:Cambridge (Grande-Bretagne)Statut:PostdocSecteur:public
Description de l'annonce:
Post-doctoral Computer Programmers in Structural Bioinformatics
Department of Biochemistry

Applications are invited for two posts in connection with a collaboration between Cambridge University and Tripos Associates to develop software for fold recognition and comparative modelling. A computer programmer is required to integrate existing software from Cambridge into the Tripos package and to develop new alogrithms. A post-doctoral research associate with knowledge of and experience in bioinformatics is required to develop new approaches in structural bioinformatics. The posts are available up to three years depending on experience and qualifications on the University scale (£17,626 - £26,491).

The closing date for applications is 3rd October 2002.

The Department operates a no-smoking policy.


The University is committed to equality of opportunity.


Contacts:Written applications including CV and names and addresses of two referees should be sent to Mrs B Humphry, Department of Biochemistry, 80 Tennis Court Road, Old Addenbrooke's Site, Cambridge, CB2 1GA, email: bjh32@mole.bio.cam.ac.uk.

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03/09/2002[MM]Chimie-informatique/lead informatics/CRP-VITRY
Source:ABG (ref:ABG-7317)
Date de parution:03/09/2002Date limite de réponse:?
Lieu:Vitry (France)Statut:CDDSecteur:prive
Description de l'annonce:
The Chemo-Informatics group, Aventis Pharma Paris, has a position open for a dynamic individual with a excellent track records in Chemo-Informatics, Chemometrics, Computational Chemistry and/or Molecular Modeling.
In this position you will be expected to invent, develop, and/or implement algorithms, methods and methodologies in one or more of the following areas: knowledge-base reasoning systems, large data set analysis / chemometrics, data mining, automatic pharmacophore perception, physico-chemical and bio-pharmaceutic property predictions, virtual screening and diversity analysis. You will also participate in the design, integration, deployment of software or in-house developed tools associated with drug discove
ry. You will closely work with medicinal chemistry, molecular modelling, compound management, screening, drug metabolism and pharmaco-kinetic department, drug-safety department, and information systems. You will closely interact with global and local project teams and with the other informatics groups located on different sites (USA, Germany).
This position requires a PhD in Computational Chemistry, or in Molecular Modeling or in Chemometrics with a minimum of one or two years of post-doctoral experience preferably in pharmaceutical industry. Knowledge of Bioinformatics is an asset.
Experience in using large database systems (data, 2D, 3D), good programming and scripting skills (C/C++, Java, Perl, Python, VB, SQL, ..), knowledge of Linux/Unix operating environment as well as of commercial drug discovery software is required. A good understanding of medicinal chemistry is highly desirable. Strong interpersonal skills, capacity and enthusiasm for working in an international, multi-disciplinary team as well as in a project managed environment are required.
This position is located in Paris (France).
Contacts:For further information please contact
Claude Luttmann (claude.luttmann@aventis.com),
Phone:+33 1 58 93 38 30,
Cell Phone: +33 (0) 6 82 80 92 27
Fax: +33 1 58 93 34 78.
Application with CV should be sent to
Dr Claude Luttmann,
Aventis Pharma, CRP,
13 quai Jules Guesde, BP14,
F-94403 Vitry-sur-Seine France

Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying.

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30/08/2002[MM]Thèse en Modélisation Moléculaire
Source:ABG (ref:ABGt-2203)
Date de parution:30/08/2002Date limite de réponse:?
Lieu:Southampton (Grande-Bretagne)Statut:ThèseSecteur:public
Description de l'annonce:
Nous recherchons un doctorant en modélisation moléculaire dans le groupe du Dr. Jonathan Essex à l'Université de Southampton (UK), pour étudier "Le Dévelopement de Méthodes de Calculs d'Energie Libre Rapides appliqué au drug discovery".

Cette position est en partie financée par Celltech. Le projet implique le dévelopement et l'application de nouvelles méthodes pour le calcul d'énergies libres de liaison protéine/ligand.
Le poste est ouvert a tout candidat citoyen de la CEE, possédant un diplome en Chimie, Physique ou Biochimie.

Disponibilité recherchée : immediate
Le salaire annuel est de £8000 (~ 12,500 euros) minimum.

Le département de Chimie de l'Universite de Southampton est l'un des meilleurs départements de Chimie de Grande Bretagne, il a atteint le grade 5 dans toutes les sections de Recherche.
Les thèmes de Recherche du Dr. Jonathan Essex concernent l'application des méthodologies de simulations aux problèmes d'intérêt chimiques et biochimiques. Son travail trouve une application directe dans l'industrie pharmaceutique, avec laquelle il collabore de manière intensive. Il a reçu en 2002 la médaille Marlow de la Royal Society of Chemistry.

Plus d'informations sur le groupe du Dr. Jonathan Essex sont disponibles à l'adresse : http://www.soton.ac.uk/~chemphys/jessex
Contacts:Pour déposer votre candidature envoyez un CV ainsi que les noms et emails de deux références, à
Mme Jill Queen the University of Southampton
(email: jcq@soton.ac.uk, telephone: +44 (0)23 8059 4121).
Pour plus d'informations contactez le Dr J.W. Essex jwe1@soton.ac.uk ou www.soton.ac.uk/~chemphys/jessex

Merci de préciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la référence ABG de cette offre.

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07/08/2002[MM]PostDoc position in Bioinformatics
Source:Bioinformatics.ca - Bioinformatics Jobs
Date de parution:18/07/2002Date limite de réponse:?
Lieu:Boston (Massachussets)Statut:PostdocSecteur:public
Description de l'annonce:
Company/Institution: Northeastern University

Job Title: PostDoc position in Bioinformatics

Required Skills:
PhD in biology, structural biology, bioinformatics, physics, computer science, mathematics, statiscits or related disciplines is required. Programming experience for non-computer science applicants (especially C/C++, Java, Perl, SQL) and/or website and database construction are advantage.

Job Description:
There are several projects available, from protein folding theory to large-scale methods, which also includes protein network and expression data analysis and development and maintenance of innovative web database resource for molecular biology. Work in close collaboration with experimental laboratories. PhD in biology, structural biology, bioinformatics, physics, computer science, mathematics, statiscits or related disciplines is required. Programming experience for
non-computer science applicants (especially C/C++, Java, Perl, SQL) and/or website and database construction are advantage. For applicants with computer science degree, knowledge of biology, biochemistry, molecular biology is a plus. The position is for two years with possible extention.
Interested applicants should send CV, statement of research interests and the names and addresses of three references to Valentin Ilyin, ilyin@mozart.bio.neu.edu, 414 Mugar, Department of Biology, Northeastern University, Boston, MA 02115.
Contacts:Contact for more information and questions please contact :
Valentin Ilyin
Northeastern University
414 Mugar, Northeastern University
Boston, MA 02115, MA. US
Phone: 1-617-373-4031
ilyin@mozart.bio.neu.edu

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07/08/2002[MM]Postdoctoral Fellow
Source:Bioinformatics.ca - Bioinformatics Jobs
Date de parution:21/07/2002Date limite de réponse:?
Lieu:Ikoma (Japon)Statut:PostdocSecteur:public
Description de l'annonce:
Required Skills:
Ph.D (candidates who are about to submit their Ph.D. dissertation will also be considered). Knowledge of Structural Biology, and programming skills, especially in the context of managing and analyzing large data bases. The candidate is also expected to be reasonably skilled in oral and written English. For non-Japanese applicants, a knowledge of Japanese is not a requirement but those who have some exposure to the language will be given preference.

Job Description:
Two postdoctoral positions are open in the Bioinformatics Unit of the Graduate School on Information Science. The group is fairly new and is supervised by Nobuhiro Go (Professor), Takeshi Kawabata (Associate Professor) and Gautam Basu (Associate Professor). Nara Institute of Science and Technology is situated in the vicinity of Nara city and close to Kyoto and Osaka.

The postdoctoral positions are fairly independent and the candidate is expected to launch innovative projects in the field of structural bioinformatics under the close supervision of the group leader. In addition, the candidate is expected to take part in group activities which include development of databases and creating programs that would be widely used by the bioinformatics community.

Salary and benefits will be at the level of assistant professor scale of Japanese National Universities. The exact amount will depend on qualifications and experience of the candidate. The initial appointment will be for one year, renewable up to three years.

Please send a cover letter describing your interest and qualifications along with (1) Current curriculum Vitae/Resume (2) a full publication list and five reprints (3) Names of two references with full contact information including e-mail address. Screening will begin immediately and proceed until suitable applicants are found.

Please visit our website for more details.
Contacts:Send Resume to: gautam@is.aist-nara.ac.jp

Contact for more information:
Gautam Basu
Nara Institute of Science and Technology
8916-5 Takayama
Ikoma,JP
Phone: +81-743-5616
Fax: +81-743-5617
gautam@is.aist-nara.ac.jp
http://nara.aist-nara.ac.jp/index-E.htm

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07/08/2002[MM]Modélisateur moléculaire chez L'Oréal
Source:http://www.ibcp.fr/GGMM/emplois.html
Date de parution:25/06/2002Date limite de réponse:?
Lieu:Aulnay (France)Statut:CDISecteur:prive
Description de l'annonce:
MODELISATEUR MOLECULAIRE - Paris -France - (25 juin 2002)

Vous ne ressemblez à personne.
Bien entendu, vous voulez intégrer une entreprise qui ne ressemble à aucune autre.
Imaginez... L'Oréal. Le plus beau portefeuille de marques internationales dans le monde de la beauté, qui s'appuie sur une recherche à la pointe de la technologie. Quelques faits de l'année 2000 : L'Oréal a déposé 420 brevets, lancé environ 450 nouveaux produits, vend 85 produits à la seconde et a plus que triplé son chiffre d'affaires consolidé (12,7 milliards d'Euros) en 10 ans...mais avant tout L'Oréal représente une formidable aventure humaine partagée à travers le monde autour de la beauté, l'innovation et la conquête de nouveaux marchés.

L'Oréal recherche un Modélisateur Moléculaire pour son Département Modélisation et Evaluations Rapides. Le poste est basé à Aulnay (93) dans notre Centre International de Recherche Avancée consacré aux Sciences de la Matière.

Rejoignez les 2700 chercheurs du Groupe L'Oréal passionnés par la cosmétique et spécialisés dans une trentaine de disciplines scientifiques (chimie, biologie, physique, physico-chimie, biotechnologies , toxicologie, génétique, pharmacie, formulation cosmétique...) au service de nos différents métiers : le capillaire (coloration, soin et hygiène du cheveu, coiffage) et la peau (soin, maquillage, hygiène corporelle, protection solaire, parfums).

Rattaché au Responsable Modélisation et Statistique, vous travaillerez en étroite collaboration avec les chimistes de synthèse, à la modélisation et à la conception de molécules originales et innovantes.
Votre mission consistera à développer plusieurs modèles structure-activités prédictifs et pertinents permettant de faire des propositions aux chimistes de nouvelles molécules à synthétiser possédant les propriétés cosmétiques et biologiques adéquates.

Titulaire d'un Doctorat, vous maîtrisez les méthodes de modélisation moléculaire, en particulier les techniques modernes de QSAR : descripteurs moléculaires 2D et 3D, techniques de sélection des descripteurs pertinents et d'évaluation de la qualité prédictive des modèles structure-activité.
Une première expérience (post-doctorale ou industrielle), au cours de laquelle vous avez géré un programme de recherche en collaboration avec des chimistes serait un plus.
Par ailleurs vous avez une bonne pratique des logiciels usuels de modélisation moléculaire ainsi que des langages et environnements de programmation informatique, et de bonnes connaissances en chimie.
Ouvert, pragmatique et rigoureux, vous avez le sens du travail en équipe pluridisciplinaire.
L'Oréal accueille avant tout de fortes personnalités génératrices d'idées.

Faire partie de ceux qui imagineront L'Oréal demain : voici votre L'Oréalité !
Contacts:Postulez en ligne en indiquant le numéro de référence suivant : 223

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06/08/2002[MM]Bourse de thèse fléchée Inter///Bio
Source:http://germ.cnrs-orleans.fr/annonces.htm
Date de parution:06/08/2002Date limite de réponse:17/07/2002
Lieu:Paris (France)Statut:ThèseSecteur:public
Description de l'annonce:
Dynamique interne de Biomolécules
Grâce à l'utilisation de nouvelles méthodes spectroscopiques de RMN récemment développées au Laboratoire, nous pouvons caractériser les mouvements internes de biomolécules telles que les protéines et leurs complexes. Il est possible de localiser ces mouvements, et notamment de distinguer la mobilité du squelette d'une protéine de celle des chaînes latérales des acides aminés. Nous voulons aussi caractériser les échelles de temps de ces mouvements, qui varient des picosecondes jusqu'aux microsecondes.

Directeur de Thèse : Geoffrey Bodenhauden
Equipe d'accueil : Laboratoire de Résonance Magnétique Nucléaire, Département de Chimie, ENS Paris
Bourse du Ministère : Bourse fléchée qui a été attribuée à ce sujet par l'Ecole Doctorale Inter///Bio.
Contacts:Après consultation avec le Directeur de Thèse, les candidat(e)s devront présenter le sujet devant le jury de l'Ecole Doctorale, probablement entre le 15 et le 17 juillet 2002, en vue de l'attribution définitive de la bourse fléchée à l'un(e) des candidat(e)s.
Début de la thèse : Octobre 2002
Contenu Scientifique du programme de Thèse
Informations administratives :
Renseignements relatifs à l'Equipe d'Accueil Doctorale (EAD)
Laboratoire de Résonance Magnétique Nucléaire, Département de chimie, Ecole Normale Supérieure, 24 rue Lhomond, 75231 Paris 05
Responsable de l'EAD et directeur de thèse: Pr Geoffrey Bodenhausen
Téléphone : :01 44 32 33 89
Télécopie : 01 44 32 33 97
E.mail : Geoffrey.Bodenhausen@ens.fr
Renseignements relatifs à l'Unité de Recherche
Nom et appartenance : UMR 8642
Directeur : Pr Pierre Sinaÿ
Téléphone : 01 44 32 33 89
Télécopie : : 01 44 32 33 97
E.mail : Pierre.Sinay@ens.fr

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06/08/2002[MM]Biology PhD Student in Bioinformatics Laboratory
Source:Bioinformatics.ca - Bioinformatics Jobs
Date de parution:18/07/2002Date limite de réponse:?
Lieu:Boston (Massachussets, USA)Statut:ThèseSecteur:public
Description de l'annonce:
Company/Institution: Northeastern University

Job Title: Biology PhD Student in Bioinformatics Laboratory

Required Skills:
Particularly appropriate are those who have experience in one or more computer languages, C/C++, Java, Perl/CGI, HTML and others, experience with database development and support, MySQL, PostgressSQL, SQL language is a plus. (Molecular ) Biology or biochemistry background is also a plus.

Job Description:
The Department of Biology at Northeastern University has an opening for a PhD Student in the bioinformatics laboratory. Those who are interested in work on protein theory, protein folding, stability, sequence alignments, structure superposition of proteins and DNA/RNA etc. are welcome to apply. Two types of candidates are appropriate for this field. One is from a natural science field such as biology, biochemistry, molecular biology, chemistry or physics who wish to learn computer and math and the second is from math, statistics and computer science who wish to learn biology. Particularly appropriate are those who have experience in one or more computer languages, C/C++, Java, Perl/CGI, HTML and others, experience with database development and support, MySQL, PostgressSQL, SQL language is a plus. Biology or biochemistry background is also a plus.
Contacts:Send Resume to: ilyin@neu.edu

Contact for more information and questions please contact :
Valentin Ilyin
Northeastern University
414 Mugar, Northeastern University
Boston, MA 02115, MA. US
Phone: 1-617-373-4031
ilyin@mozart.bio.neu.edu

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24/07/2002[MM]PhD in Bioinformatics/Computational Biochemistry
Source:Ph. Marc (AGM2)
Date de parution:24/07/2002Date limite de réponse:15/08/2002
Lieu:Norwich (Grande-Bretagne)Statut:ThèseSecteur:public
Description de l'annonce:
Studentship
School of Information Systems

Applications are invited for a PhD in Bioinformatics/Computational Biochemistry at the University of East Anglia. The postholder will undertake research on the EPSRC project "Understanding Protein Domain Motions through Simulation with a Focus on Citrate Synthase". The supervisor will be Dr Steven Hayward.

Background
Proteins are molecular machines designed to carry out specific tasks. For a large number of proteins, their structure and function is known, but the key question remains largely unanswered: what is the relationship between structure and function? The study of protein dynamical behavior will provide the answer to this question, but experimental techniques do not gives us a complete picture of the processes occurring at the atomic level. The computational technique of molecular dynamics simulation presents an atomic level description of protein dynamical behavior and has recently provided us with some important insights [1].

The aim of the project will be to understand the detailed mechanisms of domain closure in enzymes by making comparisons between experimentally determined functional movements in domain proteins and results from molecular dynamics simulations. The project will utilise information stored in the new DynDom database of protein domain movements (see http://www.sys.uea.ac.uk/dyndom ) which is being developed in a bioinformatics approach to understanding and predicting functional movements in proteins[2]. The research project will build upon our recent simulation study of the enzyme citrate synthase[3].

References
[1]H.J.C. Berendsen, S.Hayward, "Collective protein dynamics in relation to function", Current Opinions in Structural Biology, 10 (2), 165, 2000.
[2] S.Hayward,"Structural Principles Governing Domain Motions in Proteins", Proteins, Structure, Function and Genetics, 36, 425, 1999.
[3]D.Roccatano, A.E.Mark and S.Hayward,"Investigation of the Mechanism of Domain Closure in Citrate Synthase by Molecular Dynamics Simulation",J. Mol. Biol., 310, 1039, 2001.

To apply you should have or expect to be awarded a First or Upper Second Class Honours degree or MSc in an appropriate discipline.

The studentship is sponsored by EPSRC and is offered at the rate of £8,000 per year for three years, plus tuition fees. The post is available from October 2002.
Contacts:Further information may be obtained from Dr Steven Hayward,
Tel: 01603 593542 or e-mail: sjh@sys.uea.ac.uk

To apply please send a CV, covering letter and names/addresses of two academic referees to:
Ms C. Bramwell, Research Administrator, School of Information Systems, University of East Anglia, Norwich NR4 7TJ.
Applications via email are not permitted.

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22/07/2002[MM]These en chem-informatique / bio-informatique
Source:ABG (ref:ABGt-2123)
Date de parution:15/07/2002Date limite de réponse:12/09/2002
Lieu:Illkirch (France)Statut:ThèseSecteur:public
Description de l'annonce:
Cette thèse s’inscrit dans le cadre du génopole Alsace-Lorraine ("Du gène au Médicament") et des thématiques de l’IFR-85 Gilbet Laustriat (Récepteurs couplés aux Protéines G) afin de faciliter la découverte de nouveaux candidats médicaments à partir de cibles génomiques originales.

Résumé du sujet de recherche: Cette étude vise a développer une méthode bioinformatique originale dont le but est la conception focalisée de ligands (chimiothèques) de RCPGs, qui représente la famille de cibles thérapeutiques la plus importante du génome humain.

Profil du candidat recherché :
- Formation : DEA (nécessaire) en chimie théorique, chimie-informatique, bio informatique, ou informatique
- Connaissances de bases en chimie-physique théorique
- notions de modélisation moléculaire
- aptitude à la programmation (C, C++, perl, java)
- facilité d’adaptation à un travail dans un environnement pluridisciplinaire.
Contacts:contacter:
Dr. Didier ROGNAN : Equipe de Bioinformatique, UMR 7081, Pharmacochimie de la Communication Cellulaire, 67400 Illkirch
Tél : 03.90.24.42.35,
e-mail : didier.rognan@pharma.u-strasbg.fr

Merci de préciser dans votre courrier de candidature et/ou lors de vos contacts, la source (l'Association Bernard Gregory) et la référence ABG de cette offre.

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18/07/2002[MM]Enzyme Function And Reaction Mechanisms: Computational Studies
Source:ABG (ref:ABGe-879)
Date de parution:16/07/2002Date limite de réponse:16/09/2002
Lieu:Cleveland (Ohio, USA)Statut:PostdocSecteur:public
Description de l'annonce:
A postdoctoral position is open at Cleveland State University (Ohio -USA) for 2 years (with possible extention for another year). Different projects are proposed in collaboration with Cleveland Clinic:
1) NOS enzyme
2) Reaction mechanism of Cl- oxidation to Cl+ by myeloperoxydase
3) Modeling the AT1 receptor
4) Activity of Factor V (blood coagulation cofactor).
In close collaboration with experimentalists our main tools used for these projects are molecular modelling, QM/MM approaches and MD simulations. The salary is very attractive depending on condidate experience.

You should hold a Ph.D. or equivalent degree in biochemistry, biophysics, chemistry or physics or a related discipline. Very motivated scientist willing to work in a multidisciplinary team and a previous experience with computational methods is appreciable but not a requirement.
Contacts:For application please send or email your CV + at least 1 recommendation letter to :
Dr. A. ABABOU
NMR Center (MSB)
Leicester University
University Road
Leicester LE1 9HN
UK
phone: 44 (0) 116 223 3071
fax: 44 (0) 116 223 1503
e-mail: aa116@le.ac.uk

Thank you for quoting Association Bernard Gregory and the ABG job reference number, when applying.

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17/07/2002[MM]Enhancing Molecular Docking Through High-Performance Computing and Advanced Visualization
Source:Liste Bioinfo IMPG
Date de parution:17/07/2002Date limite de réponse:30/08/2002
Lieu:Nancy (France)Statut:PostdocSecteur:public
Description de l'annonce:
We have an opening for a post-doctoral fellow for up to 2 years, commencing september/october 2002 or later, to work on:

Enhancing Molecular Docking Through High-Performance Computing and Advanced Visualization Molecular docking is the natural process by which molecules recognize and interact with one another. From a computational standpoint, it also refers to the prediction of the structures of ligand-receptor complexes from the conformations of unbound ligand and unbound receptor. Molecular docking is at the center of such practical applications as protein engineering and drug design. It has already helped to design new ligands for anti-AIDS and anti-cancer agents and for the treatment of diabetes.

Structure-based molecular docking programs are based on the assumption that ligands which form favorable interactions with the receptor must have high binding affinity. They rely on the number-crunching capabilities of computers to generate and evaluate large numbers of possible bindings. Computers however do not have the experience of human beings and molecular docking methods severely limit the biochemists' ability to analyze the bindings computed and exploit their intuition and expertise to generate sound and reliable solutions. Also, most approaches to molecular docking do not take advantage of the visualization capabilities offered by modern workstations.

Major challenges in this field are (1) predicting how molecules will dock with one another and (2) identifying the factors that determine the specificity of interaction. To make significant advances, it is necessary to develop novel methods to facilitate the docking techniques by enhancing our ability to understand and analyze docking interactions and to develop hypotheses about which molecules are most likely to interact favorably. These factors can be incorporated into molecular docking by including advanced visualization and haptic (sense of touch) feedback in the process.

The main goal of this project is to develop an immersive, interactive and easy-to-use modelling environment to enhance molecular docking. The candidate will have at its disposal the state-of-the-art SGI high-performance computing technologies available at LORIA, notably the Reality Center immersive visualization facility and the Onyx 3800
shared-memory system platform.

In particular, the postdoctoral candidate is expected:
- To integrate existing molecular docking programs with the LORIA collaborative computing environment.
- To implement a haptic interface to facilitate interaction with molecular models, through a high-fidelity, 3D force-feedback device.
- To combine visualization and haptic feedback to allow interactive docking simulations in the Reality Center.
- To develop a multimodal user interface to facilitate the work of molecular scientists.

The successful candidate will have a solid background in SGI graphics software and architecture. He is also expected to have a working knowledge of programming and scripting languages such as Java, Perl and TCL/TK.Candidates having experience in parallel computing and/or grid computing will be given priority.

Salary will be approximately 21400 euros per annum. There are no restrictions on the nationality of the applicant.
Contacts:For more information on this position as well as indication of interest, please contact
Bernard Maigret (Bernard.Maigret@lctn.uhp-nancy.fr) http://www.lctn.uhp-nancy.fr
or Sylvain Petitjean (Sylvain.Petitjean@loria.fr) http://www.loria.fr

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03/07/2001[MM]ATER Physico-Chimie moléculaire et cellulaire au Muséum National d'Histoire Naturelle
Source:lettre d'information de l'iEDU
Date de parution:03/07/2001Date limite de réponse:03/09/2001
Lieu:Paris (France)Statut:ATERSecteur:public
Description de l'annonce:
Avis de vacance d'emplois d' A.T.E.R. au Muséum National d'Histoire Naturelle :

Une circulaire est envoyée, ce jour, pour affichage, à tous les Directeurs de Laboratoire et Chefs de service.

10 emplois sont ouverts au Muséum :
2 postes en Biologie des populations :
Intitulés des profils :
- Dynamique des Populations d'oiseaux
- Dynamique des communautés d'oiseaux

4 postes en Biologie des organismes :
Intitulés des profils :
- Technologies de la reproduction appliquées à la conservation d'espèces en voie de disparition ( Parc de la Haute Touche à
Azay)
- Biologie de la conservation des plantes (Conservatoire botanique national du Bassin parisien à Cherré (Sarthe)
- Phylogénie des Téléostéens (Laboratoire d' Ichtyologie générale et appliquée)
- Biologie et Biotechnologies Marines (Station de Biologie Marine de Concarneau)

2 postes en Sciences de la Terre :
Intitulés des profils :
- Préhistoire et paléoenvironnements du Quaternaire, Pléistocène supérieur (Abri Pataud)
- Modélisation hydrosédimentaire et biologique d'écosystèmes côtiers macrotidaux (Laboratoire d'Océanographie Physique)

2 postes en Biologie expérimentale :
Intitulés des profils :
- Endocrinologie évolutive (Laboratoire de Physiologie)
- Physico-Chimie moléculaire et cellulaire
Les dossiers sont à retirer à l'Administration - service du Personnel - où ils devront être retournés, au plus tard, le 3
septembre 2001, délai de rigueur, (le cachet de la poste faisant foi).
Contacts: le telephone standart ( 01.40.79.30.00), serveur : http://www.mnhn.fr

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01/07/2001[MM]ABG-6416 - Position postdoctorale en Modelisation Moleculaire
Source:association Bernard Gregory
Date de parution:01/07/2001Date limite de réponse:?
Lieu:Fresnes (France)Statut:PostdocSecteur:prive
Description de l'annonce:
ABG-6416 - Position postdoctorale en Modelisation Moleculaire
(industrie phamaceutique)

Date de debut de diffusion du poste : 18/06/2001

Au sein du Departement Sciences Pharmaceutiques de notre Centre de
Recherche, ce post-doc integrera une equipe de physico-chimistes et
de formulateurs pour un Contrat post-doctoral d'une duree de 12 mois.

Il aura pour mission de relier des etudes conformationnelles a
certaines proprietes physico-chimiques . Pour cela, il devra realiser
des analyses conformationnelles sur petites molecules (principes
actifs) en milieu solvant, en utilisant les logiciels MSI, Tripos
(Sybyl 6.6)...

Les candidats doivent etre titulaires d'un Doctorat en Chimie /
physico-Chimie avec une specialisation en modelisation moleculaire.

Nous vous remercions d'adresser CV + lettre de motivation a :
PFIZER Global Research & Development
A l'attention de Joel Vacus
Departement Sciences Pharmaceutiques
3/9 rue de la Loge BP 100
94265 FRESNES Cedex
Tel: 01 40 96 74 00 / joel.vacus@pfizer.com

Precisez dans votre courrier de candidature et/ou lors de vos
contacts, la source (l'Association Bernard Gregory) et la reference
ABG de cette offre.
Merci de nous informer des suites donnees a votre candidature sur ce
poste, si ces suites sont positives et aboutissent a votre
recrutement (E-mel: alain.valette@abg.asso.fr)
Contacts:Nous vous remercions d'adresser CV + lettre de motivation a :
PFIZER Global Research & Development
A l'attention de Joel Vacus
Departement Sciences Pharmaceutiques
3/9 rue de la Loge BP 100
94265 FRESNES Cedex
Tel: 01 40 96 74 00 / joel.vacus@pfizer.com

Precisez dans votre courrier de candidature et/ou lors de vos
contacts, la source (l'Association Bernard Gregory) et la reference
ABG de cette offre.
Merci de nous informer des suites donnees a votre candidature sur ce
poste, si ces suites sont positives et aboutissent a votre
recrutement (E-mel: alain.valette@abg.asso.fr)

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01/07/2001[MM]Researcher – Protein structure modelling NAUTILUS BIOTECH
Source:http://www.arborescience.com/public/pages_fr/jobs_detail.php?id=1413
Date de parution:25/05/2001Date limite de réponse:?
Lieu:Evry (France)Statut:CDISecteur:prive
Description de l'annonce:
Description du poste à pourvoir :

Job Description: Modelling of protein structure, folding, active sites/domains and ligand/protein-protein interaction.

Place : Evry, France

Compensation package:

-Highly competitive salary
-Stock options according to personal and Company performance

Position available immediately
Requirements: PhD in Biology, Biotechnology or similar Previous experience in modelling of protein structure
Contacts:Contact :
Contact information: Manuel Vega
CEO
mvega@nautilusbiotech.com
tel : +33 (0)6 87 69 56 38
Référence de l'offre, pour votre candidature et dans toute correspondance avec Arborescience :
ARB1413

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01/07/2000[MM]Software Developers à Gentech (Sophia antipolis)
Source:Ph. Marc (AGM2)
Date de parution:21/07/2000Date limite de réponse:?
Lieu:Sophia Antipolis (France)Statut:CDISecteur:prive
Description de l'annonce:
Software Developers à Gentech (Sophia antipolis)
Gentech is a biotechnology research laboratory and bioinformatics company. We are developing a cross-platform bioinformatics
software package for DNA and protein sequence analysis and visualisation.
Three software developer positions are available with the following requirements:
- C++ programming
- Expertise in one or more of the following platforms:Windows98-NT, Linux and MacOS
- Knowledge of 3D programming, (Quickdraw, OpenGL).
Gentech is located in the scientific park "Sophia Antipolis" in the South of France near Nice and Cannes, see our web site
www.gentech.fr.
Contacts:contact: Gentech 55, Allée Charles Victor Naudin Sophia Antipolis 06410 Biot France
Tel : 04 93 95 68 28 Fax : 04 93 95 68 27

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